本文選題：納米磷酸八鈣 + 納米磷酸三鈣��； 參考：《成都理工大學》2011年碩士論文

【摘要】：磷酸八鈣(Ca_8(HPO_4)_2(PO_4)·5H_2O,OCP)是牙齒和骨骼構(gòu)成的主要成分之一,是羥基磷灰石的重要前驅(qū)體,具有良好的生物相容性和生物活性,是較好的骨替換材料;磷酸三鈣(Ca3(PO4)2,TCP)具有與人體骨骼組織成分相似的礦物組成,具有良好的生物降解性、生物相容性和生物無毒性,當其植入人體后,降解出的Ca、P能進入活體循環(huán)系統(tǒng)形成新生骨。磷酸八鈣和磷酸三鈣用作組織修復材料,在骨修復方面有很好的應用前景。不同的制備方法對兩者的性能及其應用有重要的影響。 微乳液法是一種制備納米粒子的新方法,因其可控制顆粒尺寸、形貌及比表面等而備受關(guān)注。本研究采用反相微乳液法仿生合成了OCP、TCP納米粉體。制作了Triton X-100/正癸醇/異辛烷/水四組分體系相圖。本文采用目視和電導測量相結(jié)合的研究方法,對Triton X-100/正癸醇/異辛烷/水四組分體系的結(jié)構(gòu)進行了研究,探討了不同油相、不同比例聚乙二醇辛基苯基醚和正癸醇、不同反應物濃度以及不同溫度對該體系處于W/O結(jié)構(gòu)時最大增溶水量及體系穩(wěn)定性的影響,確定了反相微乳液法制備納米磷酸八鈣和納米磷酸三鈣的相圖區(qū)域。以此區(qū)域下的反相微乳液為模板,通過改變不同的反應條件,成功合成了不同粒徑和形貌的OCP和TCP納米顆粒。 通過透射電子顯微鏡(TEM)、X-射線衍射儀(XRD)、紅外光譜儀(FTIR)等表征手段研究了產(chǎn)物顆粒尺寸、結(jié)構(gòu)和形貌。其中OCP為棒狀納米顆粒,直徑為20～50nm,長度為60～120nm;TCP為梭狀納米顆粒,直徑為10～20nm,長度在80～110nm。 討論了不同熱處理溫度、不同水油比、不同陳化時間、不同攪拌時間以及溶液的不同pH值對OCP、TCP納米顆粒形貌、尺寸以及結(jié)晶程度等性質(zhì)的影響,結(jié)果表明改變水油比和攪拌時間可實現(xiàn)對納米OCP、TCP顆粒尺寸的控制,而陳化時間對其影響不大,而溶液pH值的改變將會導致最終產(chǎn)物的改變。
[Abstract]:5H _ 2O _ 2O _ (OCPP) is one of the main components of teeth and bones, is an important precursor of hydroxyapatite, has good biocompatibility and bioactivity, and is a better bone replacement material. Tricalcium phosphate has mineral composition similar to that of human skeletal tissue, and has good biodegradability, biocompatibility and non-toxicity. When implanted into human body, the degraded CaP can enter the living body circulatory system to form new bone. Octadecalcium phosphate and tricalcium phosphate are used as tissue repair materials and have a good application prospect in bone repair. Different preparation methods have an important effect on their properties and applications. Microemulsion method is a new method for preparing nanoparticles, which has attracted much attention because of its controllable particle size, morphology and specific surface. In this study, OCP-TCP nano-powders were synthesized by inverse microemulsion method. The phase diagram of Triton X-100 / n-decanol / isooctane / water four-component system was prepared. In this paper, the structure of Triton X-100 / n-decanol / isooctane / water four-component system was studied by means of visual and conductance measurements. The different oil phase, different proportion of polyethylene glycol octyl phenyl ether and n-decanol were discussed. The effects of different reactants concentration and temperature on the maximum solubilization water content and the stability of the system at the W / O structure were investigated. The phase diagram of nanosized octadecalcium phosphate and nanometer tricalcium phosphate prepared by reverse microemulsion method was determined. OCP and TCP nanoparticles with different particle sizes and morphologies were successfully synthesized by changing the different reaction conditions and using reverse microemulsion in this region as template. The particle size, structure and morphology of the product were studied by means of TEM and FTIR. Among them, OCP is a rod shaped particle with a diameter of 20 ~ 50 nm, a length of 60 ~ 120 nm ~ (-1), a diameter of 10 ~ (20) nm and a length of 80 ~ (10) nm ~ (-1). The effects of different heat treatment temperature, different water / oil ratio, different aging time, different stirring time and different pH value of solution on the morphology, size and crystallization degree of TCP nanoparticles were discussed. The results show that the size of TCP nanoparticles can be controlled by changing water / oil ratio and stirring time, but aging time has little effect on it, and the change of pH value of solution will lead to the change of final product.
【學位授予單位】：成都理工大學
【學位級別】：碩士
【學位授予年份】：2011
【分類號】：TB383.1

【引證文獻】

相關(guān)碩士學位論文 前1條

1 呂麗永;PLLA/β-TCP納米復合支架的制備及性能研究[D];青島大學;2013年

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本文編號：1800002