本文選題：超臨界二氧化碳注入法　切入點：維生素D_3　出處：《上海交通大學》2010年碩士論文　論文類型：學位論文

【摘要】： 本文采用殼聚糖(殼聚糖原料粉末、殼聚糖粒子、殼聚糖凝膠)和海藻酸鈉凝膠為基質載體,維生素D_3和葉黃素為藥物營養(yǎng)物,采用超臨界二氧化碳注入法,制備藥物營養(yǎng)物復合物。 本文共分三部分,第一部分,以殼聚糖原料粉末和殼聚糖粒子為載體,維生素D_3為藥物營養(yǎng)物,采用超臨界二氧化碳注入法,成功的制備維生素D_3殼聚糖復合物。利用紫外和紅外分析了注入前后維生素D_3和殼聚糖的結構;通過SEM分析考察維生素D_3在殼聚糖表面分布和分散情況;并考察了過程參數(shù)壓力、溫度、助溶劑乙醇和時間對維生素D_3負載量的影響。 第二部分,以殼聚糖粒子為載體,葉黃素為藥物營養(yǎng)物,采用超臨界二氧化碳注入法,成功的制備了葉黃素殼聚糖微粒,利用紫外分析了注入前后葉黃素的結構;采用照相機和SEM分析考察了葉黃素分布和分散情況;并考察了過程參數(shù)溫度、壓力、助溶劑乙醇和時間對葉黃素負載量的影響。 第三部分,分別以殼聚糖凝膠和海藻酸鈉凝膠為基質,維生素D_3為藥物營養(yǎng)物,采用超臨界二氧化碳注入法,成功的制備了維生素D_3復合物,考察了不同基質載體對維生素D_3負載量的影響;利用SEM分析考察維生素D_3在殼聚糖凝膠表面和內部的分散情況;并考察過程參數(shù)溫度、壓力和時間對維生素D_3負載量的影響。
[Abstract]:In this paper, chitosan (chitosan powder, chitosan particle, chitosan gel) and sodium alginate gel were used as matrix carrier, vitamin D3 and lutein were used as drug nutrients, and supercritical carbon dioxide injection method was used. Preparation of drug nutrient complex. This paper is divided into three parts. In the first part, using chitosan powder and chitosan particle as carrier, vitamin D3 as drug nutrition, supercritical carbon dioxide injection method is used. Vitamin D 3 chitosan complex was successfully prepared. The structure of vitamin D 3 and chitosan before and after injection were analyzed by UV and IR. The distribution and dispersion of vitamin D 3 on chitosan surface were investigated by SEM analysis. The effects of pressure, temperature, cosolvent ethanol and time on the loading of vitamin D _ 3 were investigated. In the second part, using chitosan particles as carrier and lutein as drug nutrition, lutein chitosan particles were successfully prepared by supercritical carbon dioxide injection. The structure of lutein before and after injection was analyzed by UV. The distribution and dispersion of lutein were investigated by camera and SEM, and the effects of process parameters such as temperature, pressure, cosolvent ethanol and time on the loading of lutein were investigated. In the third part, using chitosan gel and sodium alginate gel as matrix and vitamin D3 as drug nutrition, vitamin D3 complex was successfully prepared by supercritical carbon dioxide injection. The effects of different matrix carriers on the loading of vitamin D _ 3 were investigated; the dispersion of vitamin D _ 3 on the surface and inside of chitosan gel was investigated by SEM analysis; and the effects of temperature, pressure and time of process parameters on the loading of vitamin D _ 3 were investigated.
【學位授予單位】：上海交通大學
【學位級別】：碩士
【學位授予年份】：2010
【分類號】：R944

【引證文獻】

相關碩士學位論文 前3條

1 孫麗君;超臨界CO_2抗溶劑法備負載營養(yǎng)藥物的納米顆粒[D];上海交通大學;2011年

2 沈佩瓊;超臨界二氧化碳注入法制備活性物復合物的研究[D];上海交通大學;2011年

3 孫麗君;超臨界CO_2抗溶劑法制備負載營養(yǎng)藥物的納米顆粒[D];上海交通大學;2011年

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本文編號：1567291