本文關(guān)鍵詞： 兩親性聚合物 巰基-烯點(diǎn)擊化學(xué) 還原響應(yīng)性 膠束 藥物控釋　出處：《湖南大學(xué)學(xué)報(bào)(自然科學(xué)版)》2017年06期 　論文類型：期刊論文

【摘要】：以胱胺二鹽酸鹽、氯甲酸烯丙酯、1,6-己二硫醇及端巰基聚乙二醇單甲醚等為原料,通過(guò)巰基-烯點(diǎn)擊化學(xué)反應(yīng),合成了疏水段含二硫鍵的兩親性三嵌段共聚物mPEG-bP1-b-mPEG.對(duì)mPEG-b-P1-b-mPEG在水溶液中的自組裝行為進(jìn)行了深入的研究.結(jié)果表明,mPEG-b-P1-b-mPEG的臨界膠束濃度為0.032 mg/mL,形成膠束的平均粒徑為61.3nm.包載模擬藥物尼羅紅的釋放行為研究表明,在D,L-二硫蘇糖醇(DTT)存在的條件下,包裹在膠束中的尼羅紅可以被釋放出來(lái),顯示出快速的還原響應(yīng)性能,表明合成的兩親性三嵌段共聚物mPEG-b-P1-b-mPEG有望作為疏水性藥物載體,應(yīng)用于藥物控釋領(lǐng)域.
[Abstract]:In two the cysteamine hydrochloride, allyl chloroformate, 1,6- has two thiol and Mercapto terminated polyethylene glycol as raw materials, through thiol ene click reaction, the hydrophobic segment containing two disulfide bonds of two amphiphilic block copolymer mPEG-bP1-b-mPEG. three on mPEG-b-P1-b-mPEG self-assembly in aqueous solution were studied synthesis. The results showed that the critical micelle concentration of mPEG-b-P1-b-mPEG was 0.032 mg/mL, the average particle size of 61.3nm. micelles loaded on the drug release behavior of Nile Red simulation shows that in D, two L- dithiothreitol (DTT) conditions exist, wrapped in the micelles of Nile red can be released. Show a rapid reduction of response performance, suggesting that synthesis of two amphiphilic block copolymer mPEG-b-P1-b-mPEG three is expected as a hydrophobic drug carrier, used in the field of drug delivery.

【作者單位】： 湖南大學(xué)化學(xué)化工學(xué)院;
【分類號(hào)】：O631;TQ460.1

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