尿中MDMA和MDA的酰基衍生化-氮磷檢測氣相色譜分析法
發(fā)布時間：2018-11-09 18:52
【摘要】：研究了致幻性安非他明類藥物3,4-亞甲二氧基甲基安非他明(MDMA)和3,4-亞甲二氧基安非他明(MDA)的乙�；⑷阴；⑽宸；⑵叻□；⒍纫阴；⒁宦榷阴；⑽宸郊柞；⑽宸交酋；投趸郊柞；难苌磻獥l件,發(fā)現(xiàn)除了乙�；馑芯康母鞣N衍生化反應均可用5μL酸酐或酰氯在環(huán)己烷中于20℃10 m in內(nèi)完成。乙�；捎�20μL乙酸酐在60℃30 m in內(nèi)完成。在此基礎上建立了尿中MDMA和MDA的各種衍生化的氮磷檢測氣相色譜(GC/NPD)分析方法。方法操作簡便快速,絕大多數(shù)方法的檢出限低于10μg/L,其中二氯乙�；�、一氯二氟乙酰化、五氟苯甲酰化、五氟苯磺酰
[Abstract]:The acetylation, trifluoroacetylation, pentafluoropropionylation, heptafluorobutyloylation and dichloroacetylation of the hallucinogenic amphetamines 3- (4-methylene) methamphetamine (MDMA) and 3- (4-methylenedioxyamphetamine) (MDA) were studied, Conditions for the derivatization of monochlorodifluoroacetylation, pentafluorobenzoylation, pentafluorobenzenesulfonylation and dinitrobenzoylation, It was found that all the derivation reactions except acetylation could be completed in cyclohexane at 20 鈩，
本文編號：2321274
[Abstract]:The acetylation, trifluoroacetylation, pentafluoropropionylation, heptafluorobutyloylation and dichloroacetylation of the hallucinogenic amphetamines 3- (4-methylene) methamphetamine (MDMA) and 3- (4-methylenedioxyamphetamine) (MDA) were studied, Conditions for the derivatization of monochlorodifluoroacetylation, pentafluorobenzoylation, pentafluorobenzenesulfonylation and dinitrobenzoylation, It was found that all the derivation reactions except acetylation could be completed in cyclohexane at 20 鈩，
本文編號：2321274
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