本文選題：精神樸裂癥 + 陽(yáng)性癥狀　； 參考：《中國(guó)醫(yī)科大學(xué)》2006年碩士論文

【摘要】：前言 精神分裂癥是一種常見(jiàn)的、嚴(yán)重的精神疾患,其不良的預(yù)后是造成精神殘疾的最主要原因之一。本病至今病因未明。關(guān)于精神分裂癥發(fā)病機(jī)制的研究之所以舉步維艱,最重要的原因就是缺少有效的研究手段,即缺少于活體狀態(tài)下無(wú)創(chuàng)性研究微觀器質(zhì)性病變的有效手段。隨著多巴胺假說(shuō)的廣為接受,活體組織代謝與生化指標(biāo)測(cè)定的非侵襲技術(shù)成為研究的熱點(diǎn)。 利用GC/MS檢測(cè)毛發(fā)中沉積的酪胺含量,可以提示黑質(zhì)中腦細(xì)胞功能、活力、完整性、能量代謝等信息。是目前檢測(cè)腦內(nèi)代謝和生化成分的較為方便的手段。 對(duì)象與方法 選取95例臨床確診為精神分裂癥陽(yáng)性癥狀的病人作為實(shí)驗(yàn)組,進(jìn)行毛發(fā)中沉積的酪胺含量的檢測(cè)。同時(shí)選擇90名無(wú)精神分裂癥等中樞神經(jīng)系統(tǒng)疾病的正常人、46名管制吸毒者作為對(duì)照組進(jìn)行研究。對(duì)毛發(fā)進(jìn)行適當(dāng)前處理后,用GC/MS檢測(cè)毛發(fā)中的酪胺。 實(shí)驗(yàn)結(jié)果 將正常人群、精神病人群、吸毒人群按8pmol/mg為段劃分,計(jì)數(shù)不同酪胺水平上的例數(shù)分布,可看出精神病人群酪胺水平高于正常人群及吸毒人群。用SPSS統(tǒng)計(jì)軟件進(jìn)行方差分析,比較正常人群、精神病人群、吸毒人群的平均酪胺水平發(fā)現(xiàn)僅精神病人群與正常人群間的差異具有統(tǒng)計(jì)學(xué)意義。
[Abstract]:Preface
Schizophrenia is a common, serious mental disorder, and its poor prognosis is one of the most important causes of mental disability. The cause of this disease is not clear to date. The most important reason for the study of the pathogenesis of schizophrenia is the lack of effective research means, that is, the lack of less than a living state. With the extensive acceptance of the dopamine hypothesis, noninvasive techniques for the determination of living tissue metabolism and biochemical indicators have become a hot spot in the study.
The use of GC/MS to detect the content of tyramine in hair can indicate the function, vitality, integrity and energy metabolism of the brain cells in the substantia nigra. It is a more convenient means to detect the metabolic and biochemical components of the brain.
Object and method
95 patients with positive symptoms of schizophrenia were selected as experimental group, and the content of tyramine in hair was detected. At the same time, 90 normal people with no schizophrenia and other central nervous system diseases were selected. 46 control drug addicts were studied as control group. The hair was treated with GC/MS. Tyramine in hair.
experimental result
The normal population, the mental patient group and the drug addicts were divided according to the 8pmol/mg segment, and the number distribution on the level of tyramine was counted. It was found that the level of tyramine in the psychotic group was higher than that of the normal population and the drug addicts. The variance analysis was carried out by the SPSS software. The average tyamines level of the normal population, the semen deity crowd and the drug addicts was found to be only sperm. The difference between the disease group and the normal population was statistically significant.
【學(xué)位授予單位】：中國(guó)醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2006
【分類(lèi)號(hào)】：D919

【參考文獻(xiàn)】

相關(guān)期刊論文 前4條

1 宋建成,吉中孚;對(duì)精神分裂癥癥狀認(rèn)識(shí)的演變[J];國(guó)外醫(yī)學(xué).精神病學(xué)分冊(cè);2000年01期

2 蔣少艾,陳曉崗,廖衛(wèi)平;精神分裂癥與癲癇患者腦脊液多巴胺代謝產(chǎn)物的研究[J];湖南醫(yī)科大學(xué)學(xué)報(bào);1998年02期

3 趙寶龍,沈靜靜,許東升;尿樣測(cè)定法在住院精神分裂癥患者中的應(yīng)用[J];四川精神衛(wèi)生;1998年02期

4 劉俊亭,譚楓,彭淼,劉技揮,王巖;在管治條件下精神分裂癥患者與戒毒人員毛發(fā)中酪胺水平相關(guān)性的研究[J];中國(guó)藥物濫用防治雜志;2004年02期

，

本文編號(hào)：1936575