本文選題：視敏度　切入點(diǎn)：圖形翻轉(zhuǎn)視覺(jué)誘發(fā)電位(PRVEP)　出處：《蘇州大學(xué)》2008年碩士論文　論文類型：學(xué)位論文

【摘要】： 目的:通過(guò)正常眼和不同程度視力障礙組研究圖形翻轉(zhuǎn)視覺(jué)誘發(fā)電位(PRVEP)及視覺(jué)腦認(rèn)知事件相關(guān)電位(C-ERP)的特征及其與視敏度的相關(guān)性,探討以此作為視功能狀態(tài)評(píng)估的客觀電生理指標(biāo)。 方法:選用90只眼為實(shí)驗(yàn)對(duì)象,根據(jù)其單眼視力,分為0.1、0.5和1.0三組。(1) PRVEP通過(guò)一系列視角(8°, 4°, 2°, 1°, 30’, 15’, 7.5’)的黑白棋盤格翻轉(zhuǎn)誘發(fā)產(chǎn)生,高對(duì)比度(100%),時(shí)間頻率為2Hz。(2) ERP實(shí)驗(yàn)采用Oddball模型的三刺激主動(dòng)反應(yīng)實(shí)驗(yàn)?zāi)Ｊ?選用三組視角(分別為50’、10’、5’)刺激圖片,編制模擬隨機(jī)序列,每組呈現(xiàn)200次,含非靶刺激(75%)、標(biāo)準(zhǔn)刺激(15%)及新異刺激(10%)。PRVEP的N1、P1波成分,以及ERP中P300的P3a和P3b波成分均用于視敏度的客觀評(píng)估。 結(jié)果:PRVEP實(shí)驗(yàn)結(jié)果顯示:(1) PRVEP主要分布于枕區(qū),以O(shè)z振幅最大。(2) P1潛伏期及振幅與視角之間均存在曲線關(guān)系,在各視角組間存在顯著性差異(P0.01)。30’視角為PRVEP的最適刺激,表現(xiàn)為30’視角時(shí)P1潛伏期最短,振幅最大。(3) P1潛伏期及振幅與視敏度之間存在線性相關(guān)趨勢(shì)(R20.90),隨著視敏度的增加,P1潛伏期縮短,振幅逐漸提高。各視敏度組間,P1潛伏期及振幅均存在統(tǒng)計(jì)學(xué)差異(P0.05)。ERP實(shí)驗(yàn)結(jié)果顯示:(1) P300中P3a與P3b電極分布存在差異,P3a主要分布于額區(qū)(FCz),P3b主要分布于頂區(qū)(Pz)。(2)P3a、P3b潛伏期和振幅在各視角組間均存在顯著性差異(P0.01)。(3)P3a、P3b潛伏期和振幅與視角之間存在線性相關(guān)趨勢(shì)(R20.90),隨著視角的減小,其潛伏期延長(zhǎng),振幅降低。(4) P3a、P3b潛伏期在各視敏度組間均存在顯著性差異(P0.05)。(5)P3b潛伏期與視敏度存在負(fù)相關(guān)線性趨勢(shì)(R20.90),P3b潛伏期隨著視敏度提高而縮短。余指標(biāo)與視敏度未見明顯趨勢(shì)。 結(jié)論:(1)PRVEP與ERP成分的電極分布存在差異。(2)視覺(jué)刺激的視角影響PRVEP與ERP成分,P1、P3a及P3b各波成分與視角之間存在線性相關(guān)趨勢(shì)。(3)P1潛伏期及振幅和P3b潛伏期與視敏度之間均存在線性相關(guān)趨勢(shì)。
[Abstract]:Objective: to study the characteristics of pattern reversal visual evoked potential (PRVEP) and visual brain cognitive event-related potential (C-ERP) and their correlation with visual acuity in normal eyes and patients with different degree of visual impairment. To explore this as an objective electrophysiological index for the evaluation of visual function. Methods: 90 eyes were divided into 0. 1 0 and 1. 0 groups according to their monocular visual acuity. PRVEP was induced by a series of black and white checkerboard flips of 8 擄, 4 擄, 2 擄, 1 擄, 30, 15, 7.5). The ERP experiment was based on the three-stimulus active response model of Oddball model, and three groups of visual angle (50 / 10) stimulation pictures were used to compile the simulated random sequence, each group presented 200 times, with a high contrast ratio of 100 / 100 and a time frequency of 2Hz. The N _ 1 P _ 1 wave components of PRVEP and P3a and P3b wave components of P300 in ERP were used for objective evaluation of visual acuity. Results the results showed that PRVEP was mainly distributed in the occipital region. The peak Oz amplitude was found in the occipital region. There was a curvilinear relationship between the latency and amplitude of P1 and the angle of view. There was significant difference in the angle of view between the two groups. The optimal stimulus for PRVEP was P0.01. 30'angle. The results showed that the latency of P1 was the shortest and the amplitude was the largest at 30 'angle. There was a linear correlation trend between P1 latency and amplitude and visual acuity. The latency of P1 was shortened with the increase of visual acuity. The results of ERP experiment showed that there was a difference between P3a and P3b electrode distribution in P300. The P3a was mainly distributed in the frontal area of FCzP P3b and the P3b was mainly distributed in the parietal region of Pzanus. 2P3a P3b and P3b. There were significant differences in amplitudes among different viewing angle groups. There was a linear correlation trend between the latency and amplitude of P3aC3b and the angle of view, and with the decrease of the angle of view, there was a trend of linear correlation between the amplitude and the amplitude of P3b. There were significant differences in the latency of P3aP3b between different visual acuity groups. There was a negative correlation between the latency of P3b and the visual acuity. The latency of P3b decreased with the increase of visual acuity, but there was no obvious trend between the other indexes and the visual acuity. Conclusion there is a significant difference in the electrode distribution between ERP and PRVEP components. (2) the visual stimuli influence the linear correlation between the components of PRVEP and ERP, P1P3a and P3b waves, and the visual acuity, the latency and amplitude of P3b and the latency of P3b and visual acuity. There are linear correlation trends.
【學(xué)位授予單位】：蘇州大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2008
【分類號(hào)】：D919

【引證文獻(xiàn)】

相關(guān)期刊論文 前1條

1 邱佩鈺;王東;錢峰;陳燕;戴家雋;;視覺(jué)疲勞對(duì)駕駛?cè)俗⒁饽芰τ绊懙氖录嚓P(guān)電位研究[J];交通醫(yī)學(xué);2011年06期

，

本文編號(hào)：1576233