本文關(guān)鍵詞： 法醫(yī)毒物學(xué) 氯胺酮 乙醇 毒物代謝動(dòng)力學(xué) 家兔 顯著性差異 動(dòng)力學(xué)參數(shù) 代謝物 合用 動(dòng)力學(xué)過程　出處：《中國法醫(yī)學(xué)雜志》2010年01期 　論文類型：期刊論文

【摘要】：目的研究乙醇對(duì)氯胺酮在家兔體內(nèi)毒物代謝動(dòng)力學(xué)行為的影響。方法實(shí)驗(yàn)家兔分為單用氯胺酮組、氯胺酮與乙醇合用組及對(duì)照組,三組動(dòng)物分別灌胃氯胺酮0.15 g/kg、乙醇3.0g/kg與氯胺酮0.15 g/kg及等體積生理鹽水。分別于給藥前和給藥后不同時(shí)間點(diǎn)收集血、尿標(biāo)本,GC和GC/MS法測定氯胺酮和代謝物去甲氯胺酮濃度,WinNor-Lin軟件擬合房室模型并計(jì)算氯胺酮和去甲氯胺酮毒物代謝動(dòng)力學(xué)參數(shù)。結(jié)果氯胺酮在家兔體內(nèi)的毒物代謝動(dòng)力學(xué)過程呈一級(jí)動(dòng)力學(xué)特征,符合二室開放模型,合用乙醇后不改變其房室類型。合用乙醇組家兔體內(nèi)氯胺酮的K10、AUC和β均大于單用氯胺酮組,而T1/2K10、T1/2β、A和Cmax均小于單用氯胺酮組,兩組之間存在顯著性差異(P0.05);V/F、K01、K12、K21、T1/2K01、α、T1/2α、Tmax和B等參數(shù)兩組之間無顯著性差異(P0.05)。合用乙醇組家兔體內(nèi)氯胺酮的代謝物去甲氯胺酮的K01、A、B和Cmax等參數(shù)均大于單用氯胺酮組,而T1/2K01、Tmax均小于單用氯胺酮組,兩組之間存在顯著性差異(P0.05);V/F、K10、K12、K21、AUC、T1/2K10、T1/2α、T1/2β、β等參數(shù)兩組之間無顯著性差異(P0.05)。結(jié)論乙醇可加快氯胺酮在體內(nèi)的消除過程,促進(jìn)其轉(zhuǎn)化為去甲氯胺酮,對(duì)于氯胺酮與乙醇合并濫用的鑒定,應(yīng)考慮兩者的相互作用。
[Abstract]:Objective to study the effect of ethanol on the metabolic behavior of ketamine in rabbits. Methods Rabbits were divided into single ketamine group, ketamine combined with ethanol group and control group. Ketamine 0.15 g / kg was administered intragastrically in the three groups. Ethanol 3.0 g / kg, ketamine 0.15 g / kg and saline of the same volume. Blood and urine samples were collected at different time points before and after administration. The concentrations of ketamine and norketamine were determined by GC and GC/MS. WinNor-Lin software fitted the atrioventricular model and calculated the pharmacokinetic parameters of ketamine and norketamine. Results Ketamine metabolism in rabbits showed first-order kinetic characteristics. The K10 AUC and 尾 of ketamine group were higher than that of ketamine alone group, but T1 / 2K10 T1 / 2 尾. Both A and Cmax were lower than those in ketamine group, and there was a significant difference between the two groups (P 0.05). V / F FK01N K12K21 T1 / 2K01a T1 / 2K01a T1 / 2 偽. There was no significant difference between the two groups in Tmax and B parameters. K01A of norketamine was the metabolite of ketamine in combination with ethanol group. The parameters of B and Cmax were higher than those of ketamine group, while T1 / 2K01Tmax was lower than that of Ketamine group, there was significant difference between the two groups (P0.05). V / F K10 K12 K21 AUC T1 / 2K10 T1 / 2 偽 T1 / 2 尾. Conclusion ethanol can accelerate the elimination process of ketamine in vivo and promote its transformation into norketamine, and identify the combined abuse of ketamine and ethanol. The interaction between the two should be considered.
【作者單位】： 山西醫(yī)科大學(xué)法醫(yī)學(xué)院;
【基金】：“十一五”國家科技支撐計(jì)劃項(xiàng)目基金(2007BAK26B05) 山西省自然科學(xué)基金資助項(xiàng)目(2007011105) 山西高校科技研究開發(fā)項(xiàng)目(20041319)
【分類號(hào)】：D919.1
【正文快照】： 氯胺酮(ketamine,簡稱KE)屬N-甲基-D-天門冬氨酸(NMDA)受體拮抗劑,同屬NMDA受體拮抗劑的還有乙醇和PCP等[1]。氯胺酮入體后70%~90%經(jīng)肝P450酶主要代謝為去甲氯胺酮(norketamine,簡稱NK)。氯胺酮是一種麻醉藥,也是一種濫用藥,具有一定的精神依賴性[2]。在氯胺酮濫用人員中多種

【參考文獻(xiàn)】

相關(guān)期刊論文 前6條

1 崔宏e，

本文編號(hào)：1459628