本文選題：微型質(zhì)譜 + 源內(nèi)解離�。� 參考：《北京理工大學(xué)》2016年碩士論文

【摘要】：質(zhì)譜是一種廣泛應(yīng)用于同位素檢測、生物大分子結(jié)構(gòu)鑒定以及未知化合物定量分析的技術(shù)方法,盡管如此,質(zhì)譜的發(fā)展仍然存在許多不足之處,如體積大、.功耗高和維護(hù)比較復(fù)雜等。所有這些都會給質(zhì)譜應(yīng)用帶來許多不便之處,因此世界各國科學(xué)家研發(fā)出了不同種類的微型質(zhì)譜儀,用以滿足爆炸物檢測、個人醫(yī)療和環(huán)境保護(hù)等領(lǐng)域的需求。小型化質(zhì)譜儀體積小,功耗低,便于攜帶,且造價低,能夠滿足現(xiàn)場快速檢測的要求,因此在航空航天、國家安全等方面得到了廣泛的應(yīng)用。然而,由于儀器結(jié)構(gòu)的簡化以及對尺寸和功耗的嚴(yán)格限制,質(zhì)譜儀在小型化的同時將不可避免地造成儀器性能的下降。例如,在傳統(tǒng)的實驗室用大儀器中,多種技術(shù)被用來輔助電噴霧液滴的去溶劑化過程,有的通過加熱進(jìn)樣毛細(xì)管來提高霧化液滴中溶劑的揮發(fā)速度,還有的使用加熱同軸鞘流氣來輔助噴針霧化。但是,由于儀器整機(jī)結(jié)構(gòu)較為簡單,這些方法并不適用于微型質(zhì)譜。因此,本項研究提出了一種專門針對微型質(zhì)譜儀的去溶劑化方法——源內(nèi)去溶劑化技術(shù)。與源內(nèi)碰撞誘導(dǎo)解離技術(shù)相似,源內(nèi)去溶劑化技術(shù)也是通過電場加速帶電粒子,并使其與惰性氣體分子發(fā)生碰撞,動能轉(zhuǎn)化為內(nèi)能,導(dǎo)致帶電粒子碎裂,所不同的是,去溶劑化過程碰撞能量較低,目的是為了打碎離子加合物和帶電霧化液滴而并非是離子。該項技術(shù)能夠有效地促進(jìn)電噴霧離子源中液滴的去溶劑化,同時又可以提高譜圖的信號強(qiáng)度和信噪比,因而可以使小型化質(zhì)譜儀的靈敏度提升一倍。與實驗室質(zhì)譜儀常用的去溶劑化技術(shù)相比,源內(nèi)去溶劑化方法更加經(jīng)濟(jì)節(jié)約,也更適合于小型化質(zhì)譜儀。
[Abstract]:Mass spectrometry is widely used in isotope detection, biological macromolecular structure identification and quantitative analysis of unknown compounds. However, the development of mass spectrometry still has many shortcomings, such as large volume. High power consumption and complex maintenance. All of these will bring many inconvenience to the application of mass spectrometry, so scientists all over the world have developed different kinds of micro mass spectrometers to meet the needs of explosives detection, personal medical treatment and environmental protection. The miniaturized mass spectrometer is small in size, low in power consumption, easy to carry and low in cost, and can meet the requirements of rapid detection in the field, so it has been widely used in aerospace, national safety and so on. However, due to the simplification of the instrument structure and the strict restriction on the size and power consumption, the performance of the mass spectrometer will inevitably decrease while it is miniaturized. For example, in traditional laboratory instruments, a variety of techniques have been used to assist in the process of dissolvation of electrospray droplets, some of which increase the volatile rate of solvents in atomized droplets by heating the capillary tubes. Others use heating coaxial sheath air to assist spray-needle atomization. However, due to the simple structure of the instrument, these methods are not suitable for micro mass spectrometry. Therefore, an in-source desolvation method for micro mass spectrometers is proposed in this paper. Similar to the in-source collision-induced dissociation technique, the in-source desolvation technique also accelerates charged particles through an electric field and causes them to collide with the molecules of inert gases. The kinetic energy is converted into internal energy, which leads to the fragmentation of charged particles. The purpose of the desolvation process is to break ion adducts and charged atomizing droplets rather than ions. This technique can effectively promote the dissolvation of droplets in the electrospray ion source, at the same time, it can improve the signal intensity and signal-to-noise ratio of the spectrogram, so that the sensitivity of the miniaturized mass spectrometer can be doubled. Compared with the usual dissolvent technology used in laboratory mass spectrometer, the in-source desolvation method is more economical and more suitable for miniaturized mass spectrometers.
【學(xué)位授予單位】：北京理工大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2016
【分類號】：TH843

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1 薛振華;便攜式質(zhì)譜儀源內(nèi)去溶劑化技術(shù)研究[D];北京理工大學(xué);2016年

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本文編號：2019419