本文選題：質(zhì)子治療裝置　切入點(diǎn)：旋轉(zhuǎn)機(jī)架　出處：《中國(guó)科學(xué)院研究生院（上海應(yīng)用物理研究所）》2015年博士論文

【摘要】：質(zhì)子治療裝置是國(guó)際上新型治愈腫瘤的大型醫(yī)療設(shè)備，其中的旋轉(zhuǎn)機(jī)架（Gantry）具有結(jié)構(gòu)大、精度高的特點(diǎn)。上海質(zhì)子治療示范裝置是國(guó)內(nèi)首次對(duì)質(zhì)子治療技術(shù)的全面自主研發(fā)，其中新型的旋轉(zhuǎn)機(jī)架是具有180度回轉(zhuǎn)角度，旋轉(zhuǎn)半徑5.4m，重達(dá)162t的大型精密機(jī)械結(jié)構(gòu)。作為首臺(tái)國(guó)內(nèi)自主研發(fā)的旋轉(zhuǎn)機(jī)架，其瞄準(zhǔn)目前國(guó)際上正在積極研發(fā)的新型半回轉(zhuǎn)的結(jié)構(gòu)，設(shè)計(jì)主體結(jié)構(gòu)與指標(biāo)參數(shù)與國(guó)際接軌，具有空間大、重量輕、性價(jià)比高等特點(diǎn)。但由于參考資料匱乏、等中心精度要求極高、配套建筑設(shè)計(jì)復(fù)雜，同時(shí)又必須具備高性價(jià)比以適應(yīng)市場(chǎng)競(jìng)爭(zhēng)，所以其設(shè)計(jì)難度極高。 本文先介紹了質(zhì)子治療技術(shù)的概況，然后較系統(tǒng)的介紹了目前國(guó)際上旋轉(zhuǎn)機(jī)架的發(fā)展以及試研時(shí)期的一些計(jì)算與分析。 本文的目的：為保證旋轉(zhuǎn)機(jī)架的結(jié)構(gòu)具有高性價(jià)比，必須在保證精度的情況下進(jìn)行結(jié)構(gòu)優(yōu)化以大幅減輕整體重量，從而達(dá)到質(zhì)優(yōu)價(jià)廉。 采用的方法：采用物理優(yōu)化、經(jīng)驗(yàn)設(shè)計(jì)優(yōu)化、拓?fù)鋬?yōu)化與尺寸優(yōu)化的多種方法綜合運(yùn)用。 運(yùn)用的主要結(jié)構(gòu)優(yōu)化設(shè)計(jì)的理論基礎(chǔ)：拓?fù)鋬?yōu)化ESO有限元法，尺寸優(yōu)化中的遺傳算法與序列二次規(guī)劃算法以及試驗(yàn)設(shè)計(jì)方法與響應(yīng)面技術(shù)。 運(yùn)用的軟件與計(jì)算過(guò)程：綜合采用Solidworks、ANSYS、Optimus軟件分別進(jìn)行主要零件結(jié)構(gòu)的拓?fù)渑c尺寸優(yōu)化，文章重點(diǎn)闡述其主要優(yōu)化過(guò)程并對(duì)結(jié)構(gòu)進(jìn)行驗(yàn)算。 優(yōu)化的結(jié)果：通過(guò)對(duì)多個(gè)主要部件的優(yōu)化設(shè)計(jì)和計(jì)算使得優(yōu)化后的旋轉(zhuǎn)機(jī)架重量從240t降至162t，仍然能達(dá)到等中心精度要求。這是結(jié)構(gòu)優(yōu)化設(shè)計(jì)方法首次在旋轉(zhuǎn)機(jī)架設(shè)計(jì)的應(yīng)用，起到了非常好的效果，也將結(jié)果運(yùn)用到后續(xù)的實(shí)際生產(chǎn)制造過(guò)程中，，是非常具有意義的研究工作。
[Abstract]:The proton therapy device is a new type of large medical equipment for curing tumors in the world. Among them, the rotating frame Gantrye has the characteristics of large structure and high precision. The Shanghai proton therapy demonstration device is the first fully independent development of proton therapy technology in China. Among them, a new type of rotary frame is a large precision mechanical structure with an angle of 180 degrees of rotation, a rotating radius of 5.4 m and a weight of 162 tons. As the first self-developed rotating frame in China, it aims at a new type of semi-rotating structure, which is currently being actively developed in the world. The structure and index parameters of the design body are in line with the international standard, and have the characteristics of large space, light weight, high performance-to-price ratio, etc. However, due to the lack of reference materials, the precision of the isocentric structure is very high, and the design of supporting buildings is complex. At the same time, it must have high performance and price ratio to adapt to market competition, so it is very difficult to design. This paper first introduces the general situation of proton therapy technology, and then systematically introduces the development of rotating frame in the world and some calculation and analysis in the period of trial and research. The purpose of this paper: in order to ensure that the structure of the rotating frame has high performance-price ratio, it is necessary to optimize the structure under the condition of ensuring precision in order to greatly reduce the overall weight and achieve the high quality and low price. Methods adopted: physical optimization, empirical design optimization, topology optimization and dimension optimization. The main theoretical basis of structural optimization design are topology optimization ESO finite element method, genetic algorithm and sequential quadratic programming algorithm in dimension optimization, experimental design method and response surface technology. The application of software and calculation process: SolidworksAnsys Optimus software is used to optimize the topology and size of the main parts respectively. The main optimization process and checking calculation of the structure are described in this paper. The result of optimization: through the optimization design and calculation of several main components, the weight of the optimized rotating rack can be reduced from 240 t to 162 t, and the accuracy of the rotation frame can still be achieved. This is the first application of the structural optimization design method in the design of the rotating rack. It has a very good effect, and it is a very meaningful research work to apply the results to the subsequent actual manufacturing process.
【學(xué)位授予單位】：中國(guó)科學(xué)院研究生院（上海應(yīng)用物理研究所）
【學(xué)位級(jí)別】：博士
【學(xué)位授予年份】：2015
【分類號(hào)】：TH774

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 趙立峰;王東屏;;基于OPTIMUS的通風(fēng)機(jī)進(jìn)風(fēng)口集成優(yōu)化計(jì)算[J];風(fēng)機(jī)技術(shù);2006年01期

2 段雪非;張滿洲;李浩虎;;上海質(zhì)子治療裝置束流輸運(yùn)系統(tǒng)物理設(shè)計(jì)[J];核技術(shù);2011年05期

3 張蕊;孫國(guó)慶;楊澤山;;基于OPTIMUS的臨近空間飛行器再入軌跡優(yōu)化設(shè)計(jì)[J];航天器工程;2012年02期

4 蔡偉明;質(zhì)子和其他放射治療腫瘤的比較[J];基礎(chǔ)醫(yī)學(xué)與臨床;2005年02期

5 劉世耀;質(zhì)子治療設(shè)備的現(xiàn)狀和發(fā)展[J];基礎(chǔ)醫(yī)學(xué)與臨床;2005年02期

6 何小中;楊國(guó)君;龍繼東;龐健;張開(kāi)志;石金水;;緊湊型醫(yī)用回旋加速器的物理設(shè)計(jì)[J];核技術(shù);2014年01期

7 蔡偉明;穆向魁;;質(zhì)子治療腫瘤:國(guó)內(nèi)外進(jìn)展現(xiàn)狀及其前景[J];實(shí)用腫瘤雜志;2007年06期

8 劉世耀;建造質(zhì)子治療中心的關(guān)鍵要點(diǎn)[J];醫(yī)療裝備;2003年04期

9 董志偉,喬友林,李連弟,陳育德,王潤(rùn)田,雷通海,饒克勤,王汝寬,趙平,游偉程,魯鳳珠,戴旭東,王國(guó)清,羅賢懋,周海城;中國(guó)癌癥控制策略研究報(bào)告[J];中國(guó)腫瘤;2002年05期

10 李連弟,魯鳳珠,張思維,牧人,孫秀娣,皇甫小梅,孫杰,周有尚,歐陽(yáng)寧慧,饒克勤,陳育德,孫愛(ài)明,薛志福,夏毅;中國(guó)惡性腫瘤死亡率20年變化趨勢(shì)和近期預(yù)測(cè)分析[J];中華腫瘤雜志;1997年01期

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