獼猴運(yùn)動(dòng)皮層中局部場(chǎng)電位信號(hào)的長(zhǎng)期穩(wěn)定性及其同側(cè)運(yùn)動(dòng)解析
發(fā)布時(shí)間：2018-08-24 08:04
【摘要】：物理損傷或神經(jīng)系統(tǒng)疾病等原因經(jīng)常會(huì)導(dǎo)致人們永久性地喪失運(yùn)動(dòng)功能,而腦機(jī)接口技術(shù)的出現(xiàn)給這些殘障患者帶來了新希望。腦機(jī)接口直接提取大腦的運(yùn)動(dòng)信息,繞過常規(guī)的脊髓和外周神經(jīng)系統(tǒng),直接控制外部設(shè)備,為運(yùn)動(dòng)功能重建提供了一種新思路。目前植入式腦機(jī)接口中常用的神經(jīng)信號(hào)主要有兩種：神經(jīng)元鋒電位信號(hào)和局部場(chǎng)電位信號(hào)。其中神經(jīng)元鋒電位信號(hào),具有較高的時(shí)空分辨率,可以攜帶較為豐富的運(yùn)動(dòng)信息,但是在實(shí)際應(yīng)用中難以維持較長(zhǎng)時(shí)間的有效的記錄。近年來諸多研究表明局部場(chǎng)電位信號(hào)中也蘊(yùn)含著豐富的運(yùn)動(dòng)信息,但其長(zhǎng)期穩(wěn)定性相對(duì)研究較少。另外,不同頻段的局部場(chǎng)電位信號(hào)對(duì)同側(cè)肢體運(yùn)動(dòng)的信號(hào)表征及其解析情況也尚不十分清楚。 本研究基于獼猴的腦機(jī)接口平臺(tái),在三只獼猴進(jìn)行四方向center-out實(shí)驗(yàn)時(shí),使用Blackrock的硅陣列電極同步記錄獼猴初級(jí)運(yùn)動(dòng)皮層和背側(cè)運(yùn)動(dòng)前區(qū)中的神經(jīng)信號(hào),從神經(jīng)信號(hào)特征、神經(jīng)信號(hào)與運(yùn)動(dòng)信號(hào)間的相關(guān)性以及神經(jīng)信號(hào)解碼三個(gè)方面對(duì)局部場(chǎng)電位信號(hào)的長(zhǎng)期穩(wěn)定性及其對(duì)于同側(cè)運(yùn)動(dòng)信息的解析進(jìn)行了分析和研究。結(jié)果表明在長(zhǎng)期穩(wěn)定性方面,相對(duì)于神經(jīng)元鋒電位信號(hào),局部場(chǎng)電位信號(hào)記錄質(zhì)量衰減緩慢,能夠維持相對(duì)更久的運(yùn)動(dòng)方向信息。在神經(jīng)元鋒電位信號(hào)記錄質(zhì)量較差時(shí),局部場(chǎng)電位信號(hào)能夠表現(xiàn)出更好的解碼性能。特別地,在整個(gè)神經(jīng)電極陣列記錄不到神經(jīng)元鋒電位信號(hào)時(shí),局部場(chǎng)電位信號(hào)仍然能夠提供一定的解碼信息。在同側(cè)運(yùn)動(dòng)表征與解析方面,多個(gè)頻段的局部場(chǎng)電位信號(hào)表征了同側(cè)肢體的運(yùn)動(dòng)信息。同時(shí),同一神經(jīng)信號(hào)表現(xiàn)出與對(duì)側(cè)運(yùn)動(dòng)時(shí)顯著不同的偏好方向。解碼結(jié)果表明多個(gè)頻段能夠精確解析同側(cè)肢體的運(yùn)動(dòng)信息,其中以200-400Hz頻段的解碼性能最佳。 本研究工作分析了神經(jīng)元鋒電位信號(hào)記錄質(zhì)量較差時(shí)的局部場(chǎng)電位信號(hào)的解碼性能,并對(duì)不同頻段的局部場(chǎng)電位信號(hào)對(duì)同側(cè)肢體運(yùn)動(dòng)的信息表征及其解析進(jìn)行了深入研究。主要?jiǎng)?chuàng)新點(diǎn)在于：(1)在四方向center-out運(yùn)動(dòng)范式上,從信號(hào)特征、方向性調(diào)諧和離線解碼性能三個(gè)方面證實(shí)了局部場(chǎng)電位信號(hào)具有比神經(jīng)元鋒電位信號(hào)更好的長(zhǎng)期穩(wěn)定性；(2)研究了神經(jīng)元鋒電位信號(hào)記錄質(zhì)量在嚴(yán)重衰減甚至完全消失時(shí),局部場(chǎng)電位信號(hào)在四方向分類解碼上仍具有一定的生理意義；(3)研究表明多個(gè)頻段的局部場(chǎng)電位信號(hào)蘊(yùn)含同側(cè)肢體運(yùn)動(dòng)的有效信息,尤其在200-400Hz頻段信號(hào)的解碼性能相對(duì)較好,四方向的分類正確率最高。 本文通過對(duì)局部場(chǎng)電位信號(hào)的長(zhǎng)期穩(wěn)定性及其對(duì)于同側(cè)肢體運(yùn)動(dòng)信息表征和解析的研究表明,大腦運(yùn)動(dòng)皮層的局部場(chǎng)電位信號(hào)同樣蘊(yùn)含豐富的肢體運(yùn)動(dòng)信息,可以作為一種穩(wěn)定的神經(jīng)信號(hào)源,相關(guān)研究結(jié)果將進(jìn)一步促進(jìn)和增強(qiáng)植入式腦機(jī)接口的臨床應(yīng)用。
[Abstract]:Physical injury or nervous system diseases often lead to permanent loss of motor function, and the emergence of brain-computer interface technology brings new hope to these disabled patients. Brain-computer interface directly extracts motor information from the brain, bypasses the conventional spinal cord and peripheral nervous system, and directly controls the peripheral equipment, which provides a new idea for the reconstruction of motor function. At present, there are two kinds of nerve signals commonly used in implantable brain-computer interface: neuron spike signal and local field potential signal. The neuron spike signal has high spatial and temporal resolution and can carry abundant motion information, but it is difficult to maintain a long time effective record in practical application. In recent years, many studies have shown that the local field potential signal also contains abundant motion information, but its long-term stability is relatively less studied. In addition, the characterization and resolution of the local field potential signals in different frequency bands for the motion of the ipsilateral limbs are still unclear. In this study, we used silicon array electrode of Blackrock to record the neural signals in the primary motor cortex and the dorsal premotor area of the three macaques during the four-direction center-out experiment based on the brain computer interface platform of the rhesus monkey, and recorded the neural signals from the characteristics of the neural signals in the primary motor cortex and the dorsal premotor area of the rhesus monkeys. The long-term stability of the local field potential signal and the analysis of the ipsilateral motion information are analyzed and studied in three aspects: the correlation between the nerve signal and the motion signal and the decoding of the nerve signal. The results show that relative to the neuron spike signal, the recording quality of the local field potential signal attenuates slowly in the long term and can maintain the movement direction information for a longer time. When the recording quality of the neuron spike signal is poor, the local field potential signal can show better decoding performance. In particular, the local field potential signal can still provide decoding information when the whole neural electrode array can not record the neuron spike signal. In the aspect of ipsilateral motion representation and analysis, local field potential signals of multiple frequency bands represent the motion information of ipsilateral limbs. At the same time, the same neural signal showed a significantly different preference direction from the contralateral motion. The decoding results show that multiple frequency bands can accurately parse the motion information of the ipsilateral limbs, and the decoding performance of the 200-400Hz band is the best. In this study, the decoding performance of the local field potential signal with poor recording quality of the neuron spike signal is analyzed, and the characterization and analysis of the information of the local field potential signal on the ipsilateral limb motion in different frequency bands are deeply studied. The main innovations are as follows: (1) in the four-direction center-out motion paradigm, it is proved that the local field potential signal has better long-term stability than the neuron spike signal from three aspects: signal characteristics, directional tuning and off-line decoding performance; (2) when the recording quality of the neuron spike signal is seriously attenuated or even completely disappeared, the local field potential signal still has some physiological significance in the four-direction classification and decoding; (3) the results show that the local field potential signals in multiple frequency bands contain effective information about the motion of the ipsilateral limbs, especially in the 200-400Hz band, the decoding performance of the signals is relatively good, and the classification accuracy of the four directions is the highest. In this paper, the long-term stability of the local field potential signal and the characterization and analysis of the ipsilateral limb motion information show that the local field potential signal of the cerebral motor cortex also contains abundant limb motion information. It can be used as a stable neural signal source, and the related research results will further promote and enhance the clinical application of implanted brain-computer interface (BCI).
【學(xué)位授予單位】：浙江大學(xué)
【學(xué)位級(jí)別】：博士
【學(xué)位授予年份】：2014
【分類號(hào)】：TN911.7
本文編號(hào)：2200159
[Abstract]:Physical injury or nervous system diseases often lead to permanent loss of motor function, and the emergence of brain-computer interface technology brings new hope to these disabled patients. Brain-computer interface directly extracts motor information from the brain, bypasses the conventional spinal cord and peripheral nervous system, and directly controls the peripheral equipment, which provides a new idea for the reconstruction of motor function. At present, there are two kinds of nerve signals commonly used in implantable brain-computer interface: neuron spike signal and local field potential signal. The neuron spike signal has high spatial and temporal resolution and can carry abundant motion information, but it is difficult to maintain a long time effective record in practical application. In recent years, many studies have shown that the local field potential signal also contains abundant motion information, but its long-term stability is relatively less studied. In addition, the characterization and resolution of the local field potential signals in different frequency bands for the motion of the ipsilateral limbs are still unclear. In this study, we used silicon array electrode of Blackrock to record the neural signals in the primary motor cortex and the dorsal premotor area of the three macaques during the four-direction center-out experiment based on the brain computer interface platform of the rhesus monkey, and recorded the neural signals from the characteristics of the neural signals in the primary motor cortex and the dorsal premotor area of the rhesus monkeys. The long-term stability of the local field potential signal and the analysis of the ipsilateral motion information are analyzed and studied in three aspects: the correlation between the nerve signal and the motion signal and the decoding of the nerve signal. The results show that relative to the neuron spike signal, the recording quality of the local field potential signal attenuates slowly in the long term and can maintain the movement direction information for a longer time. When the recording quality of the neuron spike signal is poor, the local field potential signal can show better decoding performance. In particular, the local field potential signal can still provide decoding information when the whole neural electrode array can not record the neuron spike signal. In the aspect of ipsilateral motion representation and analysis, local field potential signals of multiple frequency bands represent the motion information of ipsilateral limbs. At the same time, the same neural signal showed a significantly different preference direction from the contralateral motion. The decoding results show that multiple frequency bands can accurately parse the motion information of the ipsilateral limbs, and the decoding performance of the 200-400Hz band is the best. In this study, the decoding performance of the local field potential signal with poor recording quality of the neuron spike signal is analyzed, and the characterization and analysis of the information of the local field potential signal on the ipsilateral limb motion in different frequency bands are deeply studied. The main innovations are as follows: (1) in the four-direction center-out motion paradigm, it is proved that the local field potential signal has better long-term stability than the neuron spike signal from three aspects: signal characteristics, directional tuning and off-line decoding performance; (2) when the recording quality of the neuron spike signal is seriously attenuated or even completely disappeared, the local field potential signal still has some physiological significance in the four-direction classification and decoding; (3) the results show that the local field potential signals in multiple frequency bands contain effective information about the motion of the ipsilateral limbs, especially in the 200-400Hz band, the decoding performance of the signals is relatively good, and the classification accuracy of the four directions is the highest. In this paper, the long-term stability of the local field potential signal and the characterization and analysis of the ipsilateral limb motion information show that the local field potential signal of the cerebral motor cortex also contains abundant limb motion information. It can be used as a stable neural signal source, and the related research results will further promote and enhance the clinical application of implanted brain-computer interface (BCI).
【學(xué)位授予單位】：浙江大學(xué)
【學(xué)位級(jí)別】：博士
【學(xué)位授予年份】：2014
【分類號(hào)】：TN911.7
【參考文獻(xiàn)】
相關(guān)期刊論文 前1條
1 ;Development of an invasive brain machine interface with a monkey model[J];Chinese Science Bulletin;2012年16期
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