本文選題：對(duì)氯扁桃酸 + 羥丙基-β-環(huán)糊精��； 參考：《化學(xué)工程》2017年09期

【摘要】：研究了對(duì)氯扁桃酸(4-ClMA)對(duì)映體在含有羥丙基-β-環(huán)糊精(HP-β-CD)的聚乙二醇(PEG)/硫酸銨[(NH_4)_2SO_4]雙水相體系中的萃取分配行為�？疾炝藀H、PEG相對(duì)分子質(zhì)量、PEG質(zhì)量分?jǐn)?shù)、(NH_4)_2SO_4質(zhì)量分?jǐn)?shù)、HP-β-CD濃度、4-ClMA濃度以及萃取溫度對(duì)拆分效果的影響。實(shí)驗(yàn)結(jié)果表明:雙水相萃取拆分具有很好的手性分離能力,HP-β-CD對(duì)(R)-4-ClMA的識(shí)別能力大于對(duì)(S)-4-ClMA的識(shí)別能力;當(dāng)pH=6.5,PEG2000的質(zhì)量分?jǐn)?shù)為20%,(NH_4)_2SO_4的質(zhì)量分?jǐn)?shù)為20%,HP-β-CD濃度為1 mmol/L,4-ClMA濃度為0.13 mmol/L,萃取溫度為25℃時(shí),分離因子α達(dá)到1.61,性能因數(shù)PfR達(dá)到0.065。
[Abstract]:The extraction and distribution behavior of p-chloromandelic acid 4-ClMA-enantiomer in the aqueous two-phase system containing hydroxypropyl- 尾 -cyclodextrin (HP- 尾 -CDCD) was studied.The effects of pH ~ (-1) PEG relative molecular weight and PEG mass fraction (NH _ 4S _ 2SO _ 4 mass fraction), HP- 尾 -CD concentration and extraction temperature on the resolution were investigated.The experimental results show that the chiral separation ability of HP- 尾 -CD is better than that of RP- 4-ClMA by aqueous two-phase extraction.When the mass fraction of PEG2000 is 20, the mass fraction of HP- 尾 -CD is 0.13 mmol / L, the extraction temperature is 25 鈩，

本文編號(hào)：1756082