本文選題：MoO_(3-x)量子點　切入點：界面水蒸發(fā)　出處：《哈爾濱工業(yè)大學(xué)》2017年碩士論文

【摘要】：氧化鉬是重要的過渡金屬氧化物,在傳感器、催化劑、電致變色、光致變色、鋰離子電池、太陽能電池等許多方面都具有潛在的應(yīng)用價值。而非化學(xué)計量比的氧化鉬在可見-近紅外區(qū)具有可調(diào)的光學(xué)吸收,是一種很好的光熱材料。本文利用水熱法合成出氧缺陷MoO_(3-x)量子點,通過理論模擬研究了MoO3-x量子點特殊的光學(xué)性能,并將其用于界面水蒸發(fā)和光聲成像引導(dǎo)的腫瘤光熱與光動力協(xié)同治療。具體的研究內(nèi)容如下:本文采用水熱法,通過改變殼聚糖的量、反應(yīng)溫度和Mo元素的濃度,獲得多種形貌的氧化鉬納米材料,通過透射電子顯微鏡、X-射線衍射能譜和紫外-可見-近紅外吸收光譜進行表征,最終選擇在可見-近紅外區(qū)吸收較高的還原態(tài)氧化鉬量子點作為光熱材料,并利用X-射線光電子能譜、電子順磁共振分析、拉曼光譜證明了MoO3-x量子點存在氧缺陷。理論模擬證明了MoO_(3-x)量子點在可見-近紅外區(qū)的強吸收是由氧缺陷引起。另外,MoO_(3-x)量子點的紫外-可見-近紅外吸收光譜與太陽光譜相匹配。論文利用MoO_(3-x)量子點的光熱性能制備了MoO_(3-x)量子點膜用于界面水蒸發(fā)實驗,研究結(jié)果表明MoO_(3-x)量子點膜有極好的界面熱效果,在光照射下實現(xiàn)高效的界面水蒸發(fā)效果。本論文通過單一物種MoO_(3-x)量子點實現(xiàn)了光聲成像引導(dǎo)的光熱與光動力協(xié)同治療,基于MoO_(3-x)量子點強的近紅外光吸收能力,能夠?qū)⒔t外光轉(zhuǎn)換成局部高熱,同時產(chǎn)生單線態(tài)氧。因此,可以作為有效的光熱劑和光敏劑,并在細(xì)胞實驗和動物實驗中證實其優(yōu)異的抗腫瘤特性。MTT實驗表明MoO_(3-x)量子點沒有明顯的毒性。在進一步的研究中,MoO_(3-x)量子點被用來消除He La荷瘤裸鼠的腫瘤,組織學(xué)檢測表明小鼠的主要臟器沒有明顯的損傷,MoO_(3-x)量子點主要是通過肝臟和脾臟代謝掉的。此外,基于理想的光熱效果,MoO_(3-x)量子點也能被作為外源的光聲造影劑用于活體成像來描述腫瘤。綜上所述,本論文合成的MoO_(3-x)量子點在可見和近紅外區(qū)有較高的吸收,吸收光譜與太陽光譜相匹配,能產(chǎn)生很好的界面熱效果,而且MoO_(3-x)量子點單一物種作為多功能診療劑,避免了復(fù)合物體系中各組分之間互相干擾和容易泄露的缺點。
[Abstract]:Molybdenum oxide is transition metal oxides, important in catalysts, sensors, electrochromic, photochromic, lithium ion batteries, which have a potential application in many aspects such as solar battery. And non stoichiometric molybdenum oxide with adjustable light in the visible and near infrared absorption studies, is a very good thermal material. In this paper, the synthesis of oxygen deficient MoO_ by hydrothermal method (3-x) quantum dots, through theoretical simulation on the optical properties of MoO3-x quantum dots, and the interface for the water evaporation and photoacoustic imaging guided tumor photothermal and photodynamic CO treatment. The specific contents are as follows: This paper uses water thermal method, by changing the amount of chitosan concentration, reaction temperature and Mo elements, obtain molybdenum oxide nano materials with various morphologies, through transmission electron microscope, X- ray diffraction spectroscopy and UV Vis NIR absorption spectra were characterized, The final choice in the reduced state of molybdenum oxide quantum dots visible and near infrared absorption high as thermal material, and using X- ray photoelectron spectroscopy, electron paramagnetic resonance, Raman spectroscopy has proved the existence of oxygen defects in MoO3-x quantum dots. The theoretical simulation proved that MoO_ (3-x) quantum dots in the visible and near infrared region strong the absorption is caused by oxygen deficiency. In addition, MoO_ (3-x) - quantum dots UV visible near infrared absorption spectrum and the solar spectral matching. The paper uses MoO_ (3-x) MoO_ were prepared for thermal properties of quantum dots (3-x) quantum dots film interface for water evaporation experiment, the results show that the MoO_ (3-x) quantum dots film has excellent thermal interface effect, achieve efficient interfacial water evaporation effect under visible light irradiation. The single species MoO_ (3-x) quantum dots for photothermal and photoacoustic imaging guided photodynamic therapy based on collaborative, MoO_ (3-x) quantum dots strong near Infrared absorption ability to near infrared is converted into local hyperthermia, and produce singlet oxygen. Therefore, can be used as an effective photothermal agent and a photosensitizer, and in cell and animal experiments confirmed the excellent antitumor properties of.MTT assay showed that MoO_ (3-x) quantum dots have no obvious toxicity. In further research, MoO_ (3-x) quantum dots is used to remove He La nude mice tumor, histological examination showed no obvious damage to the main organs of mice, MoO_ (3-x) quantum dots is mainly through the liver and spleen metabolize. In addition, the ideal photothermal effect based on MoO_ (3-x), quantum dots can also be used as photoacoustic contrast agent for in vivo imaging to describe the exogenous tumor. In summary, the synthesis of MoO_ (3-x) has a high absorption in the visible and near infrared region of the quantum dots, the absorption spectrum and the solar spectral matching, can produce good The interface thermal effect, and MoO_ (3-x) quantum dot single species as a multifunctional diagnostic agent, avoids the interference and leakage of components in the complex system.

【學(xué)位授予單位】：哈爾濱工業(yè)大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：TQ136.12

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