【摘要】：生物芯片(biochip)技術(shù)是隨著人類基因組計(jì)劃(human genome project,HGP)發(fā)展起來的一門前沿高新技術(shù),在基因檢測(cè),藥物篩選,臨床等多個(gè)領(lǐng)域有廣闊發(fā)展前景。當(dāng)下,生物芯片光學(xué)檢測(cè)法以其靈敏度高、分析速度快、式樣用量少、成本低、易于微型化、便攜化等特點(diǎn)而受到廣泛關(guān)注。本文就生物芯片檢測(cè)平臺(tái)的控制系統(tǒng)進(jìn)行深入研究,設(shè)計(jì)一種基于ARM9處理器為硬件,Linux系統(tǒng)為底層軟件的嵌入式生物芯片檢測(cè)平臺(tái)。硬件上,7寸觸摸屏作為操作界面,機(jī)箱主體為四組電機(jī),分別是XY滑動(dòng)平臺(tái)電機(jī)、注射泵電機(jī)、LLS光源電機(jī),分別控制待測(cè)物的位置、注射樣本液體、LLS光源位置,另外,還包括輔助開關(guān)控制,分別是內(nèi)部照明開關(guān)、震動(dòng)電機(jī)開關(guān)、泄流閥開關(guān)以及LLS光源開關(guān)。軟件上,采用Linux系統(tǒng)作為底層操作系統(tǒng),移植Qt SDK作為GUI界面開發(fā)套件,PC端用Ubuntu Linux 12.04作為開發(fā)環(huán)境。界面總體分為狀態(tài)欄和功能區(qū),功能區(qū)又細(xì)分為非機(jī)械控制、機(jī)械控制、校正、測(cè)試以及幫助子模塊,具體實(shí)現(xiàn)方法涉及到GPIO、UART、IIC以及SPI等編程。文章將按照架構(gòu)設(shè)計(jì),硬件搭建,軟件編程,數(shù)據(jù)處理的順序去詳細(xì)闡述生物芯片檢測(cè)平臺(tái)的控制系統(tǒng)的設(shè)計(jì)過程,著重說明軟件控制的具體實(shí)現(xiàn)方法。本文是基于國(guó)際合作項(xiàng)目“納米量子點(diǎn)蛋白質(zhì)生物芯片關(guān)鍵技術(shù)及產(chǎn)品研發(fā)”,在著手寫本文之前作者已經(jīng)完成了一代生物芯片檢測(cè)平臺(tái)的控制系統(tǒng)的設(shè)計(jì),整個(gè)系統(tǒng)的機(jī)械控制,開關(guān)控制,數(shù)據(jù)采集與處理,GUI界面的交互等一系列功能都可以實(shí)現(xiàn),并且能夠穩(wěn)定運(yùn)行。本文的研究將為進(jìn)一步研發(fā)二代系統(tǒng)以及制備納米量子點(diǎn)蛋白質(zhì)芯片奠定了基礎(chǔ),推進(jìn)項(xiàng)目的研發(fā)進(jìn)程。
[Abstract]:Biochip (biochip) technology is a new and advanced technology developed with the Human Genome Project (human genome project,HGP). It has broad prospects in gene detection, drug screening, clinical and other fields. Nowadays, biochip optical detection method has been widely concerned because of its high sensitivity, fast analysis speed, low cost, easy miniaturization and portability. In this paper, the control system of biochip detection platform is deeply studied, and an embedded biochip detection platform based on ARM9 processor is designed. The hardware has a 7-inch touch screen as the operating interface, and the main body of the chassis is four groups of motors, namely, the XY sliding platform motor, the injection pump motor and the LLS light source motor, which respectively control the position of the object to be tested and the position of the injection sample liquid to the LLS light source. In addition, It also includes auxiliary switch control, such as internal lighting switch, vibration motor switch, drain valve switch and LLS light source switch. In software, Linux system is used as the underlying operating system, Qt SDK is transplanted as GUI interface development kit, and Ubuntu Linux 12.04 is used as the development environment. The interface is divided into status bar and function area, and the function area is subdivided into non-mechanical control, correction, test and help sub-module. The implementation method involves GPIO,UART,IIC and SPI programming. According to the sequence of architecture design, hardware construction, software programming and data processing, the design process of the control system of the biochip detection platform is described in detail in this paper, with emphasis on the realization method of software control. This paper is based on the international cooperation project "the key technology and product development of protein biochip of nanometer quantum dot". Before writing this paper, the author has completed the design of the control system of the biochip detection platform. A series of functions, such as mechanical control, switch control, data acquisition and processing GUI interface, can be realized and can run stably. The research in this paper will lay a foundation for the further research and development of the second generation system and the preparation of nanoscale quantum dot protein chip, and promote the research and development process of the project.
【學(xué)位授予單位】：貴州大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類號(hào)】：TN407
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本文編號(hào)：2217521