本文選題：微流控芯片 + 微混合器�。� 參考：《電子科技大學》2015年碩士論文

【摘要】：微流控芯片因其分析靈敏度高,輸出通量大,分析過程可自動化同時大規(guī)模制造成本低廉的優(yōu)勢,近年來在化學,生命科學以及醫(yī)學等領域得到快速發(fā)展。然而由于流道尺寸的減小導致微流道內流體呈現層流狀態(tài),引發(fā)了微尺度下液體難以混合的問題。微流控芯片中不同液體的充分混合作為實現芯片功能的基本前提,開發(fā)快速高效的微混合器非常必要。本文利用氧等離子照射施加預應力彈性基底的方法在微流道的底部制作大面積有序的微紋路。經過微紋路的流體因產生橫向的混沌渦流破壞流體的層流狀態(tài),達到提高混合效率的目的。本文首先根據三明治復合結構材料的褶皺形成理論,得出微紋路波長和幅度的計算公式,并做為后續(xù)微紋路制作的指導公式。利用專門制作可施加兩個方向預應力的夾具在平整的PDMS樣品上通過改變氧離子照射時間制作出多種形貌的微紋路。根據所得的微紋路幅度,表面形貌,樣品平整度以及微紋路形貌對液體混合效率的影響等多種因素確定微紋路制作的參數。然后,本文依據混沌對流式微混合器的設計理論,設計并制作出蛇形和螺旋形兩種流道形狀。依據已確定的微紋路制作參數在刻蝕有流道的PDMS表面制作微紋路。制作時引入了彈性掩模版解決帶有微紋路的微流控芯片的漏液問題。最后在微流控芯片中注入藍黃兩色純凈水,利用圖像處理軟件分析并計算不同形狀的流道出口處綠色混合區(qū)域占流道寬度的比值,定量表征不同流道形狀以及微紋路制作前后微混合器的混合效率。
[Abstract]:Microfluidic chips have been developed rapidly in the fields of chemistry, life science and medicine in recent years because of their advantages of high analytical sensitivity, large output flux, automation of analytical process and low cost of large-scale manufacturing.However, the decrease of channel size leads to the laminar flow of the fluid in the microchannel, which leads to the difficulty of liquid mixing in the microchannel.The full mixing of different liquids in the microfluidic chip is the basic premise to realize the function of the chip. It is necessary to develop a fast and efficient micromixer.In this paper, the prestressing elastic substrate is applied by oxygen plasma irradiation to fabricate large area ordered microveins at the bottom of the microchannel.The laminar flow state of the micro-rippled fluid is destroyed by the transverse chaotic eddy current and the mixing efficiency is improved.In this paper, according to the theory of fold formation of sandwich composite structure, the formula of wavelength and amplitude of micro-ripple is obtained, and it is used as the guiding formula of micro-ripple making.A special clamp with two direction prestressing force was used to fabricate the micro-lines of various morphologies on a flat PDMS sample by changing the irradiation time of oxygen ions.The parameters of micrograin fabrication were determined according to the range of micro-grain, surface morphology, sample smoothness and the effect of micro-grain morphology on liquid mixing efficiency.Then, according to the design theory of chaotic convection micro mixer, two kinds of flow channel shapes, snake shape and spiral shape, are designed and fabricated.According to the determined parameters of micrograin fabrication, the micrograin was made on the surface of PDMS with channel etched.An elastic mask is introduced to solve the leakage problem of microfluidic chip with micro-lines.Finally, the blue and yellow pure water was injected into the microfluidic chip, and the ratio of the green mixing area to the width of the channel at the outlet of different shapes was analyzed and calculated by image processing software.The mixing efficiency of the micromixer before and after the fabrication of the micro-grain was quantitatively characterized by different channel shapes.
【學位授予單位】：電子科技大學
【學位級別】：碩士
【學位授予年份】：2015
【分類號】：TN492

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相關博士學位論文 前1條

1 徐華國;芯片表面DNA分子機器的構建與單堿基突變的檢測[D];中國科學技術大學;2014年

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本文編號：1744307