合成一種具有pH響應(yīng)性的聚乙二醇（PEG）修飾無定形介孔氧化鐵納米粒子（AFe-PEG）.這種納米粒子可以高效負(fù)載藥物分子如阿霉素（DOX）,構(gòu)成新型多功能AFe-PEG/DOX藥物遞送體系.DOX的負(fù)載率高達(dá)948 mg/g-納米粒子.在酸性溶液中,AFePEG/DOX納米粒子不僅可以有效釋放DOX,同時(shí)可以釋放Fe離子進(jìn)行Fenton反應(yīng),將H₂ O₂轉(zhuǎn)變成·OH自由基.體外實(shí)驗(yàn)結(jié)果表明,AFe-PEG/DOX納米粒子對(duì)HeLa細(xì)胞同時(shí)具有化療和化學(xué)動(dòng)力學(xué)療法的療效.同時(shí),由于AFe-PEG/DOX納米粒子本身的磁性,使其在外部磁場中的細(xì)胞內(nèi)化效率也得到了提高.

【文章頁數(shù)】：14 頁

【文章目錄】：
I.INTRODUCTION
II.MATERIALS AND METHODS
III.RESULTS AND DISCUSSION
IV.CONCLUSION
Supporting Information
Part I.Synthesis and characterization of compounds employed in this work.
Part II.Working curve of DOX
Part III.Characterization of nanoparticles
Part IV.Thermo-gravimetric analysis(TGA)of nanoparticles
Part V.The Fluorescence images of Hela cells.
Part VI.The cellular internalization and intracellular trafficking of DOX
REFERENCES



本文編號(hào)：4016787