近半個(gè)世紀(jì)以來,癌癥已發(fā)展成為臨床醫(yī)學(xué)的重大疾病,嚴(yán)重威脅人類的生命健康。隨著全球人口總數(shù)的不斷增長、人口老齡化趨勢的逐漸加劇、環(huán)境污染以及生活方式的改變,癌癥的發(fā)病率和死亡率呈持續(xù)增長的態(tài)勢,嚴(yán)重威脅人類生命安全,阻礙社會(huì)發(fā)展。腫瘤具有無限增殖、易轉(zhuǎn)移和強(qiáng)侵潤性等特點(diǎn),給癌癥的診斷和治療帶來了極大的困難。傳統(tǒng)治療癌癥的手段主要有化學(xué)藥物治療、放射治療以及手術(shù)治療等,這些方法在一定程度上減緩并控制了腫瘤的惡化速度,但很難實(shí)現(xiàn)腫瘤的根除且缺乏特異性,容易對正常組織細(xì)胞造成影響,進(jìn)而導(dǎo)致嚴(yán)重的毒副作用。為了提高腫瘤的治療效果,科研人員發(fā)展了多種新興技術(shù),其中光療法(主要包括光熱療法和光動(dòng)力學(xué)療法)作為一種新型的抗腫瘤手段,因其具有良好的組織穿透性和較小的毒副作用,受到越來越多的關(guān)注。光熱治療(Photothermal therapy,PTT)是一種新型的微創(chuàng)腫瘤治療手段,使用該方法進(jìn)行治療時(shí),光熱轉(zhuǎn)化劑能夠?qū)⒔t外光的能量轉(zhuǎn)化為熱能,使腫瘤或癌變組織溫度上升至有效治療溫度范圍內(nèi),并利用腫瘤組織和正常組織溫度耐受力的差異,在不損傷正常組織的前提下,達(dá)到殺滅腫瘤細(xì)胞的目的。在光熱治療中,我們還...

【文章頁數(shù)】：111 頁

【學(xué)位級(jí)別】：碩士

【文章目錄】：
中文摘要
ABSTRACT
Chapter1 Introduction
    1.1 Photothmal therapy
        1.1.1 Introduction of the photothermal therapy
        1.1.2 Common photothermal agents
    1.2 Photodynamic therapy
        1.2.1 Introduction of photodynamic therapy
        1.2.2 The mechanism of photodynamic therapy
        1.2.3 The photosensitizers of photodynamic therapy
        1.2.4 The functional nanomaterials of photodynamic therapy
    1.3 Different model imaging technologies of cancer therapy
        1.3.1 Conventional single-modality imaging
        1.3.2 Multi-modality imaging
    1.4 Project design
Chapter2 TD-controlled and ICG-loaded CuS@mSiO₂ for fluorescence/PA dual-imaging guided synergistic PTT/PDT cancer therapy
    2.1 Brief introduction
    2.2 Materials and methods
        2.2.1 Experimentalmaterials and equipments
        2.2.2 Preparation and characterization of CuS@mSiO2

        2.2.3 Preparation and characterization of CuS@mSiO₂-TD/ICG
        2.2.4 Cell culture and cellular studies
        2.2.5 In vivo animal experiments
    2.3 Results and discussion
        2.3.1 Preparation and characterization of CuS@mSiO₂

        2.3.2 Drug loadingand characterization of CuS@mSiO₂-TD/ICG
        2.3.3 Cellular studies
        2.3.4 In vivo animal studies
    2.4 Brief summary
Chapter3 BSA-bioinspired gadolinium hybrid-functionalized hollow gold nanoshells for fluorescence/PA/CT/MR quad-modal imaging guided PTT/PDT cancer therapy
    3.1 Brief introduction
    3.2 Materials and methods
        3.2.1 Experimentalmaterials and equipments
        3.2.2 Preparation and characterization of Au@BSA-Gd
        3.2.3 ICG loading and characterization of ICG-Au@BSA-Gd
        3.2.4 Cell culture and cellular studies
        3.2.5 In vivo animal experiments
    3.3 Results and discussion
        3.3.1 Preparation and Characterization of HAuNs
        3.3.2 Preparation and Characterizationof Au@BSA-Gd
        3.3.3 Preparation and Characterizationof ICG-Au@BSA-Gd
        3.3.4 Cell culture and cellular studies
        3.3.5 In vivo animal studies
    3.4 Brief summary
Chapter4 Conclusion and prospect
    4.1 Conclusion
    4.2 Prospect
References
Notes on publications and participation in scientific research
Acknowledgement



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