本研究采用溶膠-凝膠法制備氧化鋅納米粒（ZnO NPs）,并對其粒徑、形貌、晶型、光學(xué)特性和pH敏感性等理化性質(zhì)進(jìn)行表征,在PC-3M和4T1兩株細(xì)胞系上對ZnO NPs的體外抗腫瘤藥效進(jìn)行評價(jià)。實(shí)驗(yàn)結(jié)果表明,ZnO NPs為粒徑均勻的球形納米顆粒,具有優(yōu)良的光學(xué)性能及pH敏感性能,對PC-3M和4T1兩株細(xì)胞系有明顯的抗腫瘤細(xì)胞藥效。上述結(jié)果表明, ZnO NPs可作為載體載帶活性物質(zhì)以產(chǎn)生抗腫瘤診斷和治療作用。 

【文章來源】：Journal of Chinese Pharmaceutical Sciences. 2020,29(09)CSCD

【文章頁數(shù)】：9 頁

【文章目錄】：
1. Introduction
2. Materials and methods
    2.1. Materials
    2.2. Cells
    2.3. Preparation of Zn O NPs
    2.4. Size distribution and morphology
    2.5. X-ray powder diffraction
    2.6. UV-Vis spectrum
    2.7. Fluorescence spectrum
    2.8. Fourier transform infrared spectrum
    2.9. p H-Responsive behavior
    2.1 0. In vitro anti-tumor activity
3. Results and discussion
    3.1. Preparation of Zn O NPs
    3.2. Size distribution and morphology
    3.3. X-ray powder diffraction
    3.4. UV-Vis spectrum
    3.5. Fluorescence spectrum
    3.6. FTIR spectrum
    3.7. p H-Responsive behavior
    3.8. In vitro anti-tumor activity
4. Conclusions


【參考文獻(xiàn)】：
期刊論文
[1]包載共軛亞油酸-紫杉醇的iRGD修飾的含溶血磷脂的溫敏脂質(zhì)體的細(xì)胞攝取和抗腫瘤藥效（英文）[J]. 郝艷麗,鐘婷,杜若,張華,劉碧林,張烜.  Journal of Chinese Pharmaceutical Sciences. 2019(02)



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