發(fā)布時間：2019-06-22 12:54

【摘要】：為了增強運載輔酶Q10的納米結(jié)構(gòu)脂質(zhì)載體(CoQ10-NLC)的透皮效果,采用促滲劑——殼聚糖季銨鹽(QCS)對CoQ10-NLC進(jìn)行了表面修飾,并結(jié)合QCS分子鏈的自聚集行為,明確了殼聚糖季銨鹽修飾的包載輔酶Q10的納米脂質(zhì)體(QCS-CoQ10-NLC)的形成機制,得到了粒徑在500 nm左右的脂質(zhì)載體。進(jìn)一步通過體外透皮實驗,考察了QCS-CoQ10-NLC的透皮吸收效果。結(jié)果顯示,經(jīng)質(zhì)量分?jǐn)?shù)0.5%的QCS修飾后,脂質(zhì)載體可將CoQ10在皮膚中的滲透總量由1.36μg/cm~2顯著增加至5.14μg/cm~2。
[Abstract]:In order to enhance the transdermal effect of nanostructured lipid carrier (CoQ10-NLC) carrying coenzyme Q10, the surface of CoQ10-NLC was modified by chitosan quaternium salt (QCS). Combined with the self-aggregation behavior of QCS molecular chain, the formation mechanism of chitosan quaternary ammonium salt modified nanoliposomes (QCS-CoQ10-NLC) containing coenzyme Q10 was obtained, and the lipid carrier with particle size of about 500 nm was obtained. Furthermore, the transdermal absorption of QCS-CoQ10-NLC was investigated by transdermal test in vitro. The results showed that the total penetration of CoQ10 in skin was significantly increased from 1.36 渭 g / cm~2 to 5.14 渭 g / cm~2. by lipid carrier modified with 0.5% QCS.
【作者單位】： 江南大學(xué)化學(xué)與材料工程學(xué)院;江南大學(xué)食品膠體與生物技術(shù)教育部重點實驗室;
【基金】：國家自然科學(xué)基金青年項目(31401533)~~
【分類號】：TB383.1;TQ460.1
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本文編號：2504600