【摘要】：酸是化學(xué)物質(zhì)中一類重要的物質(zhì),可以參加多種化學(xué)反應(yīng),可以作為溶劑,最重要的是作為催化劑,加快反應(yīng)的速率�；撬嶙鳛樗岬拇�,是常用的酸催化劑的一種,可以參加氧化還原反應(yīng)、聚合反應(yīng)、加成反應(yīng)等。由于磺酸應(yīng)用廣泛,但其污染嚴(yán)重,需要研究一種新型磺酸。近幾年,磁性納米材料成為化學(xué)領(lǐng)域的一個(gè)熱點(diǎn),受到人們的廣泛關(guān)注。它們是一種不溶性的載體,具有顆粒小、比表面大、表面帶有可修飾的基團(tuán)等優(yōu)點(diǎn)。磁性納米材料有很多種,鐵酸鈷(Co Fe2O4)是一種較為理想的磁性納米材料載體,它具有較好的化學(xué)穩(wěn)定性,同時(shí)具有廉價(jià)、易得、低毒、磁性強(qiáng)等優(yōu)點(diǎn)。本文將磺酸與磁性納米材料鐵酸鈷(Co Fe2O4)結(jié)合制得一種高效可循環(huán)的磁性納米磺酸催化劑-鐵酸鈷殼聚糖磺酸(Co Fe2O4@Cs-SO3H),用掃描電鏡(SEM)、透射電鏡(TEM)、X-射線衍射(XRD)等對(duì)其進(jìn)行了表征。在無溶劑條件下,催化水合肼、鄰苯二酸酐、芳香醛和1,3-二酮一鍋四組分反應(yīng),在較短時(shí)間內(nèi)合成酞嗪衍生物。反應(yīng)完成后,利用磁鐵將催化劑從粗產(chǎn)物中分離,避免了傳統(tǒng)的離心、過濾等繁瑣的步驟。并對(duì)催化劑進(jìn)行了多次重復(fù)利用,且不失活性。酰胺衍生物作為重要的物質(zhì),對(duì)多種藥物的合成具有重要的意義。本文制備了磁性納米材料鐵酸鈷負(fù)載磺酸(Co Fe2O4@Si O2-DASA),通過掃描電鏡(SEM)、透射電鏡(TEM)、X-射線衍射(XRD)等對(duì)其進(jìn)行了表征。研究表明,該催化劑可在無溶劑條件下催化腈和醇的反應(yīng),制備了一系列酰胺衍生物。反應(yīng)完后,催化劑可通過磁性分離,重復(fù)使用6次,此后反應(yīng)活性沒有降低,從而發(fā)展了一種制備酰胺的新方法。喹唑啉衍生物是一類非常重要的有機(jī)化合物,它是許多天然生物堿的結(jié)構(gòu)單元。近幾年,由于它們巨大的生物活性和藥物活性而受到化學(xué)藥劑師的青睞。我們制備了催化劑Co Fe2O4@Si O2-SBSAN,對(duì)制得的催化劑進(jìn)行了表征,重復(fù)實(shí)驗(yàn)的驗(yàn)證。研究表明,該催化劑可在乙醇為溶劑的條件下催化靛紅、2-氨基二苯甲酮和草酸銨一鍋三組分反應(yīng)合成喹唑啉衍生物。催化劑經(jīng)可以很容易地通過用磁鐵分離回收和再循環(huán)利用。
[Abstract]:Acid is an important class of chemical substances, which can take part in many chemical reactions, can be used as a solvent, and most importantly, as a catalyst, to accelerate the reaction rate. Sulfonic acid, as the representative of acid, is one of the commonly used acid catalysts. It can participate in redox reaction, polymerization, addition reaction and so on. Because sulfonic acid is widely used, but its pollution is serious, it is necessary to study a new type of sulfonic acid. In recent years, magnetic nanomaterials have become a hot spot in the field of chemistry. They are insoluble carriers with the advantages of small particle size, large surface size and modifiable groups on the surface. There are many kinds of magnetic nanomaterials. Cobalt ferrate (Co Fe2O4) is an ideal carrier of magnetic nanomaterials. It has good chemical stability, cheap, easy to obtain, low toxicity and strong magnetic properties. In this paper, a high efficient magnetic nanometer sulfonic acid catalyst, cobalt ferrate chitosan sulfonic acid (Co Fe2O4@Cs-SO3H), was prepared by combining sulfonic acid with magnetic nano-material cobalt ferrate (Co Fe2O4). (SEM), transmission electron microscopy (TEM),) was used to prepare the catalyst. It was characterized by X-ray diffraction (XRD) et al. Phthalazine derivatives were synthesized by catalytic reaction of hydrazine hydrate, phthalic anhydride, aromatic aldehydes and 1-tetanedione in a short time under solvent-free conditions. After the reaction was finished, the catalyst was separated from the crude product by magnets, avoiding the complicated steps of centrifugation and filtration. The catalyst was reused many times without losing its activity. As an important substance, amide derivatives play an important role in the synthesis of many drugs. In this paper, cobalt ferrate supported sulfonic acid (Co Fe2O4@Si O2-DASA) was prepared and characterized by scanning electron microscope (SEM), transmission electron microscope (TEM), X-ray diffraction (XRD) and so on. The results showed that the catalyst could catalyze the reaction of nitrile and alcohol without solvent, and a series of amide derivatives were prepared. After the reaction, the catalyst can be separated by magnetic separation and reused for 6 times. After that, the activity of the catalyst has not decreased, so a new method of preparing amides has been developed. Quinazoline derivatives are very important organic compounds, which are the structural units of many natural alkaloids. In recent years, they have been favored by chemical pharmacists because of their great bioactivity and drug activity. The catalyst Co Fe2O4@Si O 2 SBSAN was prepared, and the catalyst was characterized and verified by repeated experiments. The results showed that the catalyst could be used to synthesize quinazoline derivatives from indigo red, 2-aminobenzophenone and ammonium oxalate. The catalyst can be easily recovered and recycled by magnets.
【學(xué)位授予單位】：河北師范大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2015
【分類號(hào)】：O621.251;TB383.1

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