稀土上轉(zhuǎn)換納米載體的構(gòu)建及功能化修飾機(jī)制的研究進(jìn)展
發(fā)布時(shí)間:2018-09-08 21:05
【摘要】:稀土摻雜的上轉(zhuǎn)換納米材料可以吸收近紅外波長范圍的低能量光子而釋放出紫外光或可見光波長范圍的高能量光子。近年來,由于其獨(dú)特的光學(xué)性能,人們以稀土上轉(zhuǎn)換納米晶(UCNPs)為基礎(chǔ)構(gòu)建了許多不同的納米載體,以期能夠應(yīng)用于生物成像、光動力治療(PDT)、載藥系統(tǒng)構(gòu)建以及生物傳感等領(lǐng)域,解決當(dāng)前癌癥診斷和治療等醫(yī)學(xué)難題;赨CNPs的納米載體構(gòu)建機(jī)制種類繁多,根據(jù)納米載體的空間結(jié)構(gòu)及修飾層的位置來歸類分析,可將構(gòu)建機(jī)制大體分為三種:UCNPs為核心,修飾層在納米晶的表面;UCNPs為核,與外殼之間形成中空夾層,修飾層在中空夾層及納米晶的表面;UCNPs為空心微球的外殼,修飾層在微球的內(nèi)部及其表面。這三種UCNPs載體構(gòu)建機(jī)制各有利弊。文章將介紹這三種UCNPs載體的構(gòu)建機(jī)制及其相應(yīng)的表面修飾,總結(jié)經(jīng)過修飾后的功能化納米載體在不同領(lǐng)域中的應(yīng)用效果,并對稀土納米載體構(gòu)建機(jī)制的發(fā)展前景進(jìn)行展望。
[Abstract]:Rare-earth doped up-conversion nanomaterials can absorb low-energy photons in the near infrared wavelength range and release high-energy photons in the ultraviolet or visible wavelength range. In recent years, due to its unique optical properties, many different nano-carriers have been constructed on the basis of rare-earth up-conversion nanocrystalline (UCNPs), which can be used in the fields of bioimaging, photodynamic therapy (PDT), drug carrier system and biosensor. To solve the current medical problems such as cancer diagnosis and treatment. There are many kinds of construction mechanisms of nano-carriers based on UCNPs. According to the spatial structure of nano-carriers and the position of the modified layers, the construction mechanism can be classified into three kinds of UCNPs as the core, and the modified layer is located on the surface of nanocrystals as the core. The modified layer is the outer shell of the hollow microsphere on the surface of the hollow interlayer and nanocrystalline, and the modified layer is inside and on the surface of the microsphere. The construction mechanism of these three UCNPs carriers has its own advantages and disadvantages. This paper will introduce the construction mechanism of the three kinds of UCNPs carriers and the corresponding surface modification, summarize the application effect of the modified functionalized nano-carriers in different fields, and prospect the development prospect of the construction mechanism of rare earth nano-carriers.
【作者單位】: 中國石油大學(xué)(華東)重質(zhì)油國家重點(diǎn)實(shí)驗(yàn)室及生物工程與技術(shù)中心化學(xué)工程學(xué)院;青島大學(xué)附屬醫(yī)院;
【基金】:國家自然科學(xué)基金項(xiàng)目(21204102) 山東省科技發(fā)展計(jì)劃項(xiàng)目(2014GHY115020) 中央高;究蒲袠I(yè)務(wù)費(fèi)專項(xiàng)資金項(xiàng)目(14CX02190A)資助
【分類號】:TB383.1
本文編號:2231692
[Abstract]:Rare-earth doped up-conversion nanomaterials can absorb low-energy photons in the near infrared wavelength range and release high-energy photons in the ultraviolet or visible wavelength range. In recent years, due to its unique optical properties, many different nano-carriers have been constructed on the basis of rare-earth up-conversion nanocrystalline (UCNPs), which can be used in the fields of bioimaging, photodynamic therapy (PDT), drug carrier system and biosensor. To solve the current medical problems such as cancer diagnosis and treatment. There are many kinds of construction mechanisms of nano-carriers based on UCNPs. According to the spatial structure of nano-carriers and the position of the modified layers, the construction mechanism can be classified into three kinds of UCNPs as the core, and the modified layer is located on the surface of nanocrystals as the core. The modified layer is the outer shell of the hollow microsphere on the surface of the hollow interlayer and nanocrystalline, and the modified layer is inside and on the surface of the microsphere. The construction mechanism of these three UCNPs carriers has its own advantages and disadvantages. This paper will introduce the construction mechanism of the three kinds of UCNPs carriers and the corresponding surface modification, summarize the application effect of the modified functionalized nano-carriers in different fields, and prospect the development prospect of the construction mechanism of rare earth nano-carriers.
【作者單位】: 中國石油大學(xué)(華東)重質(zhì)油國家重點(diǎn)實(shí)驗(yàn)室及生物工程與技術(shù)中心化學(xué)工程學(xué)院;青島大學(xué)附屬醫(yī)院;
【基金】:國家自然科學(xué)基金項(xiàng)目(21204102) 山東省科技發(fā)展計(jì)劃項(xiàng)目(2014GHY115020) 中央高;究蒲袠I(yè)務(wù)費(fèi)專項(xiàng)資金項(xiàng)目(14CX02190A)資助
【分類號】:TB383.1
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