生物活性碳納米纖維增強樹脂復合材料的研制
發(fā)布時間：2018-08-13 17:26
【摘要】：隨著社會經(jīng)濟的發(fā)展,交通傷、高處墜落等高能量損傷日益增加,粉碎骨折也隨之增多。為使骨折完善愈合和良好功能恢復,需利用骨科修復器件對其進行完善的復位和固定。傳統(tǒng)金屬材料和單一高分子材料骨科器件各有不足,發(fā)展具有高強度、模量適中、應(yīng)力遮擋作用小、生物相容性的聚合物基復合材料骨修復和固定材料,有利于骨愈合及重塑,如纖維或無機填料等增強的熱塑性或熱固性復合材料等,成為骨植入材料領(lǐng)域的研究熱點。本文采用負載磷酸鈣(CaP)納米粒子短切碳納米纖維(CNF)對環(huán)氧樹脂和丙烯酸酯樹脂進行增強增韌,考察材料生物學性能,研制了一種新型骨科修復用生物納米復合材料。首先,結(jié)合溶膠凝膠、靜電紡絲和原位燒結(jié)的技術(shù)方法制備了表面和內(nèi)部負載豐富的磷酸鈣納米粒子的碳納米纖維(CNF/CaP),通過對溶膠濃度、紡絲工藝和燒結(jié)條件的優(yōu)化,成功制備了纖維直徑分布集中、納米粒子分布均勻的碳納米纖維,磷酸鈣納米粒子的主要成分為p-磷酸三鈣(β-TCP)和羥基磷灰石(HA),在碳纖維上的負載量達到大于10wt%。其次,利用高功率超聲剪切技術(shù)將連續(xù)的CNF/CaP剪切成為離散的短切纖維,其長度分布集中,通過調(diào)整超聲參數(shù),可對超聲后短切纖維的長度分布進行一定程度的控制。由于其納米粒子主要負載在纖維內(nèi)部,在物理條件處理下具有極強的納米粒子保有率,經(jīng)過500W高功率超聲40min后仍能夠保留80%的納米粒子。最后,將短切的生物活性碳納米纖維與環(huán)氧樹脂或丙烯酸酯樹脂進行復合,獲得新型骨修復用生物納米復合材料。其中磷酸鈣納米粒子負載的碳納米纖維起到增強增韌作用,并提供一定的鈣離子釋放,改善材料的生物活性和骨引導性。本文所研制的短切生物活性碳納米纖維增強環(huán)氧樹脂復合材料,其彎曲強度可達160MPa,彎曲模量可達6GPa,與人體皮質(zhì)骨的力學性能相近,能夠滿足作為接骨板材料的要求。綜上所述,負載磷酸鈣納米粒子的短切碳納米纖維可作為骨修復樹脂復合材料的填料,具有增強增韌、生物相容性好、一定生物活性的優(yōu)點,有望成為新一代骨科修復器件用生物納米復合材料。
[Abstract]:With the development of social economy, traffic injuries, high energy injuries such as falling from high places are increasing, and comminuted fractures are also increasing. In order to improve fracture healing and functional recovery, orthopaedic repair devices should be used to complete the reduction and fixation. Traditional metal materials and single polymer materials have shortcomings in orthopedic devices, such as high strength, moderate modulus, little stress shielding, biocompatibility polymer matrix composite bone repair and fixation materials, which are conducive to bone healing and remodeling. Reinforced thermoplastic or thermosetting composites, such as fiber or inorganic filler, have become the research focus in bone implant field. In this paper, epoxy resin and acrylate resin were strengthened and toughened by short cut carbon nanofiber (CNF) loaded with calcium phosphate (CaP) nanoparticles. The biological properties of the composites were investigated and a new biological nanocomposite for orthopedic repair was developed. Firstly, carbon nanofibers (CNF/CaP) loaded with rich calcium phosphate nanoparticles were prepared by sol-gel, electrospinning and in-situ sintering. The concentration of sol, spinning process and sintering conditions were optimized. Carbon nanofibers with concentrated fiber diameter distribution and uniform distribution of nanoparticles were successfully prepared. The main components of calcium phosphate nanoparticles were 尾 -TCP and hydroxyapatite (HA), loaded on carbon fiber for more than 10 wts. Secondly, continuous CNF/CaP shearing is transformed into discrete short cut fiber by high power ultrasonic shear technique, and its length distribution is concentrated. By adjusting ultrasonic parameters, the length distribution of short cut fiber after ultrasonic can be controlled to a certain extent. Because the nanoparticles are mainly loaded inside the fiber and have a strong retention rate under physical conditions, 80% nanoparticles can still be retained after 500W high power ultrasonic 40min. Finally, a novel biological nanocomposite for bone repair was obtained by compounding the short cut biological activated carbon nanofibers with epoxy resin or acrylate resin. Among them, the carbon nanofibers supported by calcium phosphate nanoparticles can enhance the toughness, provide certain calcium ion release, and improve the biological activity and bone guidance of the materials. The short cut biological activated carbon nanofiber reinforced epoxy resin composite has a flexural strength of 160 MPA and a flexural modulus of 6 GPA, which is similar to the mechanical properties of human cortical bone and can meet the requirements of bone plate material. In conclusion, short cut carbon nanofibers loaded with calcium phosphate nanoparticles can be used as fillers for bone repair resin composites, with the advantages of enhanced toughness, good biocompatibility and certain biological activity. It is expected to be a new generation of biomaterials for orthopaedic repair devices.
【學位授予單位】：北京化工大學
【學位級別】：碩士
【學位授予年份】：2015
【分類號】：TB332
本文編號：2181676
[Abstract]:With the development of social economy, traffic injuries, high energy injuries such as falling from high places are increasing, and comminuted fractures are also increasing. In order to improve fracture healing and functional recovery, orthopaedic repair devices should be used to complete the reduction and fixation. Traditional metal materials and single polymer materials have shortcomings in orthopedic devices, such as high strength, moderate modulus, little stress shielding, biocompatibility polymer matrix composite bone repair and fixation materials, which are conducive to bone healing and remodeling. Reinforced thermoplastic or thermosetting composites, such as fiber or inorganic filler, have become the research focus in bone implant field. In this paper, epoxy resin and acrylate resin were strengthened and toughened by short cut carbon nanofiber (CNF) loaded with calcium phosphate (CaP) nanoparticles. The biological properties of the composites were investigated and a new biological nanocomposite for orthopedic repair was developed. Firstly, carbon nanofibers (CNF/CaP) loaded with rich calcium phosphate nanoparticles were prepared by sol-gel, electrospinning and in-situ sintering. The concentration of sol, spinning process and sintering conditions were optimized. Carbon nanofibers with concentrated fiber diameter distribution and uniform distribution of nanoparticles were successfully prepared. The main components of calcium phosphate nanoparticles were 尾 -TCP and hydroxyapatite (HA), loaded on carbon fiber for more than 10 wts. Secondly, continuous CNF/CaP shearing is transformed into discrete short cut fiber by high power ultrasonic shear technique, and its length distribution is concentrated. By adjusting ultrasonic parameters, the length distribution of short cut fiber after ultrasonic can be controlled to a certain extent. Because the nanoparticles are mainly loaded inside the fiber and have a strong retention rate under physical conditions, 80% nanoparticles can still be retained after 500W high power ultrasonic 40min. Finally, a novel biological nanocomposite for bone repair was obtained by compounding the short cut biological activated carbon nanofibers with epoxy resin or acrylate resin. Among them, the carbon nanofibers supported by calcium phosphate nanoparticles can enhance the toughness, provide certain calcium ion release, and improve the biological activity and bone guidance of the materials. The short cut biological activated carbon nanofiber reinforced epoxy resin composite has a flexural strength of 160 MPA and a flexural modulus of 6 GPA, which is similar to the mechanical properties of human cortical bone and can meet the requirements of bone plate material. In conclusion, short cut carbon nanofibers loaded with calcium phosphate nanoparticles can be used as fillers for bone repair resin composites, with the advantages of enhanced toughness, good biocompatibility and certain biological activity. It is expected to be a new generation of biomaterials for orthopaedic repair devices.
【學位授予單位】：北京化工大學
【學位級別】：碩士
【學位授予年份】：2015
【分類號】：TB332
【參考文獻】
相關(guān)期刊論文 前1條
1 沈烈;喬飛;張宇強;張稚燕;彭懋;朱飛燕;;炭纖維增強羥基磷灰石/聚乳酸復合生物材料的力學性能和體外降解性能[J];復合材料學報;2007年05期
，本文編號：2181676
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