【摘要】：碳球具有獨特的結(jié)構(gòu)和優(yōu)良的物化性能，能夠應用于吸附材料、催化劑載體、電極材料以及藥物輸送等領(lǐng)域。通過功能化CSs后，引入一些特殊物質(zhì)，使其具有某些特殊的性能，如磁學、電學和光學等，來拓展碳球的應用范圍。本文將磁性和溫敏性材料引入碳球，使其成為具有磁和溫度雙重響應的復合材料，預計其在生物醫(yī)學、靶向藥物控釋等領(lǐng)域具有潛在的應用價值。 本論文以葡萄糖、葡萄糖酸亞鐵和十六烷基三甲基溴化銨（CTAB）為原料，采用水熱法制得磁性碳球（MCSs）。然后以混酸氧化MCSs，，在其表面引入羥基；再通過羥基與硅烷偶聯(lián)劑KH-570反應，從而在MCSs表面引入雙鍵。在此基礎(chǔ)上，通過引發(fā)劑、交聯(lián)劑的作用，將溫敏聚合物聚N-異丙基丙烯酰胺（PNIPAM）接枝到MCSs表面，形成包覆層。采用場發(fā)射掃描電子顯微鏡、紅外光譜儀、熱重分析儀、差示掃描量熱法和振動磁強計等手段對產(chǎn)物進行表征和分析。結(jié)果如下： 1、懫用綠色源料葡萄糖為碳源，與其結(jié)構(gòu)相似的葡萄糖酸亞鐵為鐵源，利用條件溫和的水熱反應體系制備粒徑均勻，形貌規(guī)整，表面富含含氧官能團并具有一定磁性的碳球MCSs�？疾炝似咸烟撬醽嗚F、CTAB的用量、葡萄糖溶液的濃度、反應時間和反應溫度對產(chǎn)物形貌、結(jié)構(gòu)的影響，并探討了MCSs的形成機理。得到了MCSs的最佳制備條件：葡萄糖溶液濃度0.1mol/L，葡萄糖酸亞鐵質(zhì)量為0.1g、CTAB質(zhì)量為0.4g、反應溫度170℃、反應時間12h。 2、在氧化和硅烷化MCSs的基礎(chǔ)上，以NIPAM為溫敏單體、KPS為引發(fā)劑、MBA為交聯(lián)劑，在MCSs表面成功地接枝了溫敏性聚合物�？疾炝藛误w、引發(fā)劑和交聯(lián)劑用量對接枝、形貌和性能的影響。得到最佳接枝聚合反應條件：每0.2g硅烷化的MCSs中加入0.6g NIPAM，引發(fā)劑KPS質(zhì)量為單體的1%，交聯(lián)劑MBA為單體的15%。分析結(jié)果表明所得產(chǎn)物具有磁性和溫敏性。 3、以制備的PNIPAM-MCSs為載體，進行阿司匹林藥物負載與緩釋實驗。緩釋實驗結(jié)果表明，隨著時間的推遲，藥物的釋放增加并最終達到平衡。由于高于LCST溫度時溫敏性聚合物殼收縮使得45℃累積釋放的量比25℃高。
[Abstract]:Carbon spheres have unique structure and excellent physical and chemical properties, and can be used in adsorption materials, catalyst carriers, electrode materials and drug transportation. After functionalization of CSs, some special materials are introduced to make them have some special properties, such as magnetism, electricity and optics, to expand the application of carbon spheres. In this paper, magnetic and temperature sensitive materials are introduced into carbon spheres to become composites with both magnetic and temperature responses, which are expected to have potential applications in biomedicine, targeted drug controlled release and so on. In this paper, magnetic carbon ball (MCSs). Was prepared by hydrothermal method using glucose, ferrous gluconate and cetyltrimethylammonium bromide (CTAB) as raw materials. Then the hydroxyl group was introduced on the surface of MCSs by mixed acid oxidation, and then the double bond was introduced on the surface of MCSs by the reaction of hydroxyl group with silane coupling agent KH-570. On this basis, the thermo-sensitive polymer poly (N-isopropylacrylamide) (PNIPAM) was grafted onto the surface of MCSs by the action of initiator and crosslinking agent to form a coating layer. The products were characterized and analyzed by means of field emission scanning electron microscope, infrared spectrometer, thermogravimetric analyzer, differential scanning calorimetry and vibratory magnetometer. The results are as follows: 1. Using green source glucose as carbon source and ferrous gluconate with similar structure as Tie Yuan, the particle size is uniform and the morphology is regular by using the hydrothermal reaction system with mild conditions. The surface is rich in oxygen functional groups and has a magnetic carbon ball MCSs. The effects of the amount of ferrous gluconate CTAB, the concentration of glucose solution, reaction time and reaction temperature on the morphology and structure of the product were investigated. The formation mechanism of MCSs was also discussed. The optimum preparation conditions of MCSs were obtained as follows: the concentration of glucose solution was 0.1 mol / L, the mass of ferrous gluconate was 0.4 g, the reaction temperature was 170 鈩

本文編號：2141671