本文選題：磁響應(yīng)型微膠囊 + 層層組裝　； 參考：《沈陽工業(yè)大學(xué)》2015年碩士論文

【摘要】：近年來，響應(yīng)型微膠囊被廣泛應(yīng)用于表面涂層、防腐材料、光電學(xué)、生物醫(yī)學(xué)及藥物傳輸?shù)阮I(lǐng)域，并在這些領(lǐng)域做出越來越重大的貢獻(xiàn)。微膠囊技術(shù)發(fā)展的最終目標(biāo)是實現(xiàn)芯材物質(zhì)在特定的時間、位置按照一定的速率進(jìn)行可控的釋放。但是，目前對于微膠囊釋放的調(diào)控手段僅限于被動式的滲透釋放和破壞式的瞬間釋放。 本文采用水熱法制備均一性良好且尺寸可控的Fe3O4納米顆粒，并通過類St ber法對Fe3O4進(jìn)行SiO2的包覆，再通過層層組裝的方法將尺寸較小的Fe3O4顆粒嵌于微膠囊的聚電解質(zhì)囊壁上，將SiO2刻蝕，最終得到了一種中心和囊壁均帶有磁性顆粒的磁響應(yīng)型微膠囊。本文通過調(diào)節(jié)攪拌前驅(qū)體的水浴溫度及VEG/VDEG的比值實現(xiàn)了對磁性顆粒大小的調(diào)控；改變TMAH的量發(fā)現(xiàn)加入1.6mL時最適合TEOS在磁性顆粒表面發(fā)生水解，，且改變TEOS的加入量可以實現(xiàn)對微膠囊的裝載能力的調(diào)控；層層組裝法制備微膠囊的過程中，離子強度的增加不利于制備磁響應(yīng)微膠囊。 在微膠囊的可控釋放實驗中，對比有無外加靜磁場的釋放曲線發(fā)現(xiàn)，80min內(nèi)，4000G的磁場作用下微膠囊釋放了約80%的芯材物質(zhì)，而無磁場時僅釋放41%（4000G磁場下僅需25min）；增大磁場強度至5800G，釋放80%的芯材只需37min，且80min時釋放量可達(dá)96%。對比相同條件下囊壁有無磁性顆粒嵌入的微膠囊的釋放曲線發(fā)現(xiàn)，在磁場作用下的主動式擠壓釋放過程中，外磁場對磁性顆粒的吸引作用引起的微膠囊之間的相互擠壓起主導(dǎo)作用。 以上結(jié)果均證明了磁場導(dǎo)致的微膠囊形變及內(nèi)部壓強的改變對芯材物質(zhì)釋放速率的調(diào)控性。與以往的微膠囊的釋放方式相比，本文的可控釋放是一種新型的、調(diào)控性更強的主動式擠壓釋放，且微膠囊的裝載空間可調(diào)，可重復(fù)使用。相對于其它壓力擠壓方式，磁性顆粒具有良好的生物相容性，且磁力擠壓可實現(xiàn)對芯材釋放的“遠(yuǎn)程”（無直接接觸）控制，對于在生物體內(nèi)進(jìn)行靶向藥物傳輸和藥物可控釋放更具有實際應(yīng)用價值。
[Abstract]:In recent years, responsive microcapsules have been widely used in the fields of surface coating, anticorrosive materials, photoelectricity, biomedicine and drug transport, and have made more and more contributions in these fields. The ultimate goal of the development of microencapsulation technology is to realize the controllable release of the core material at a certain time and position at a certain rate. However, the current regulation of microcapsule release is limited to passive osmotic release and destructive instantaneous release. In this paper, Fe _ 3O _ 4 nanoparticles with good homogeneity and controllable size were prepared by hydrothermal method. Fe _ 3O _ 4 particles were coated with Sio _ 2 by St-like ber method, and the smaller Fe _ 3O _ 4 particles were embedded on the wall of microencapsulated polyelectrolyte capsules by layer-by-layer assembly. Finally, a magnetically responsive microcapsule with magnetic particles in the center and the wall of the capsule was obtained by etching the Sio _ 2. In this paper, the size of magnetic particles is controlled by adjusting the water bath temperature of agitated precursor and the ratio of VEGF / VDEG, and it is found that the addition of 1.6 mL of TMAH is most suitable for the hydrolysis of TEOS on the surface of magnetic particles. The loading capacity of microcapsules can be controlled by changing the amount of TEOS, and the increase of ionic strength is not conducive to the preparation of magnetically responsive microcapsules in the process of preparing microcapsules by layer-by-layer assembly. In the controlled release experiment of microcapsules, it was found that the microcapsules released about 80% of the core material under the action of magnetic field within 80 minutes, but only 41% (25min) in the absence of magnetic field, compared with the release curve with or without an external static magnetic field. When the magnetic field intensity is increased to 5800G, it takes only 37 mins to release 80% of the core material, and the release amount can reach 96g at 80min. Comparing the release curves of microcapsules with or without magnetic particles embedded in the wall of the capsule under the same conditions, it is found that in the process of active extrusion release under the action of magnetic field, The external magnetic field plays a leading role in squeezing the microcapsules caused by the attraction of magnetic particles. The above results show that the deformation of microcapsules induced by magnetic field and the change of internal pressure can regulate the release rate of core materials. Compared with the previous release methods of microcapsules, the controlled release in this paper is a new and more controllable active extrusion release, and the loading space of the microcapsules is adjustable and can be reused. Compared with other pressure extrusion methods, magnetic particles have good biocompatibility, and magnetic extrusion can achieve "remote" (no direct contact) control of core release. It has more practical application value for target drug delivery and controlled drug release in vivo.
【學(xué)位授予單位】：沈陽工業(yè)大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2015
【分類號】：TB33;TQ460.1

【參考文獻(xiàn)】

相關(guān)期刊論文 前2條

1 金誼;朱以華;劉望才;王家榮;房江華;;以碳酸鈣微球為模板的生物相容微膠囊的制備[J];過程工程學(xué)報;2009年04期

2 ;Study on the Morphology,Particle Size and Thermal Properties of Vitamin A Microencapsulated by Starch Octenylsucciniate[J];Agricultural Sciences in China;2010年07期

本文編號：2085247