本文選題：光熱治療 + 碳基復合納米材料　； 參考：《東北師范大學》2017年碩士論文

【摘要】：近年來,癌癥成為損害人類健康的重要疾病之一。傳統(tǒng)的治療方法包括手術(shù),放療和化療,往往難以達到預期的治療效果,而且放療和化療還會對正常的組織產(chǎn)生毒副作用,對機體損害嚴重。隨著生物醫(yī)學技術(shù)的不斷地發(fā)展,光熱治療(PTT)成為研究熱點。光熱治療利用可吸收近紅外光(NIR)的納米試劑將光轉(zhuǎn)換成高溫熱量,使腫瘤部位溫度升高,從而殺死腫瘤組織。由于近紅外激光的高滲透性和低衰減性以及對腫瘤部位針對性的照射,光熱治療實現(xiàn)了腫瘤組織的被動靶向治療,從而降低了對正常組織的毒副作用。在已報導的光熱轉(zhuǎn)換材料中,碳基納米材料由于極高的光熱轉(zhuǎn)換效率、良好的生物相容性及穩(wěn)定性等優(yōu)點而備受關(guān)注。同時,在癌癥早期階段發(fā)現(xiàn)并及時治療是治療癌癥的關(guān)鍵。因此,設(shè)計制備能同時實現(xiàn)成像診斷和高效光熱治療的碳基復合納米粒子仍然是一個巨大挑戰(zhàn)。本文以一種新穎簡便,并且重復性好的合成策略,得到尺寸均一、分散性良好的Fe_3O_4@C/ZnP復合納米粒子。所合成的粒子尺寸和形貌是可調(diào)控的。制備的粒子具備良好的生物相容性,較高的載藥量和pH/NIR雙響應(yīng)藥物釋放性,可用于光熱-化學協(xié)同治療。該納米粒子具有較強的磁性,可作為造影劑用于核磁成像(MRI)。因此,合成的Fe_3O_4@C/ZnP復合納米粒子在同時核磁成像診斷和協(xié)同光熱-化學治療方面具有良好的應(yīng)用前景。在進一步工作中,我們用一種新穎、重復性良好的方法合成了具有雙面神結(jié)構(gòu)的多功能Au@C/MnO復合納米粒子�；谔蓟鉄岵牧峡晌战t外光,Au@C/MnO雙面神復合納米粒子可用于光熱治療和光聲成像(PAI)造影劑;同時,Mn~(2+)具有順磁性可用于MRI,Au納米粒子可應(yīng)用于計算機斷層掃描(CT)成像,因此Au@C/MnO納米粒子具有集CT成像、T1核磁成像和PA成像于一體的多模成像能力和光熱治療能力。經(jīng)實驗證明,該納米粒子具有很高的載藥能力和pH/NIR雙響應(yīng)藥物釋放能力,可用作藥物載體進行化學治療。所以,制備的Au@C/MnO雙面神復合納米粒子在多模成像診斷和協(xié)同光熱-化學治療癌癥方面具有很大的潛力。
[Abstract]:In recent years, cancer has become one of the most important diseases harmful to human health. The traditional treatment methods include surgery, radiotherapy and chemotherapy, which are often difficult to achieve the desired therapeutic effect. Moreover, radiotherapy and chemotherapy can also produce toxic side effects on normal tissues and cause serious damage to the body. With the development of biomedical technology, photothermal therapy (PTT) has become a research hotspot. Photothermal therapy converts light into high temperature heat by means of NIR (absorbable near infrared light) nanoparticles, which increases the temperature of the tumor and kills the tumor tissue. Because of the high permeability and low attenuation of near infrared laser and the targeted irradiation to the tumor site, photothermal therapy can realize the passive targeted therapy of tumor tissue, thus reducing the toxicity and side effect to normal tissue. Among the reported photothermal conversion materials, carbon based nanomaterials have attracted much attention due to their high photothermal conversion efficiency, good biocompatibility and stability. At the same time, early detection of cancer and timely treatment is the key to the treatment of cancer. Therefore, it is still a great challenge to design and fabricate carbon-based composite nanoparticles that can achieve both imaging diagnosis and high-efficiency photothermal therapy. In this paper, a novel, simple and reproducible synthesis strategy is used to obtain Fe3O _ 4C / ZnP composite nanoparticles with uniform size and good dispersion. The size and morphology of the synthesized particles are adjustable. The prepared particles have good biocompatibility, high drug loading and double response drug release at pH / NIR, and can be used in photothermal chemotherapeutic therapy. The nanoparticles have strong magnetic properties and can be used as contrast media for nuclear magnetic imaging (MRI). Therefore, the synthesized Fe3Oobo-4C- / ZnP composite nanoparticles have a good prospect in simultaneous nuclear magnetic imaging diagnosis and photothermal chemotherapeutic cooperation. In further work, a novel and reproducible method has been used to synthesize the multifunctional Aur / MNO composite nanoparticles with double facet structure. Based on the fact that carbon based photothermal material can absorb near infrared light, Aur C / MNO composite nanoparticles can be used in photothermal therapy and photoacoustic imaging (PAI) contrast agent, and mn ~ (2) has paramagnetic properties, it can be used in computer tomography (CT) imaging. Therefore, Autelian C / MNO nanoparticles have the ability of multimode imaging and photothermal therapy, which are integrated with CT imaging, T1 nuclear magnetic field imaging and PA imaging. It has been proved that the nanoparticles have high drug loading ability and double response drug release ability of pH / NIR, which can be used as drug carrier for chemotherapeutic therapy. Therefore, the prepared Audistant C / MNO composite nanoparticles have great potential in multimode imaging diagnosis and synergistic photothermal chemotherapeutic therapy of cancer.
【學位授予單位】：東北師范大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：R73-36;TB383.1

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相關(guān)期刊論文 前1條

1 Guosheng Song;Linbo Han;Weiwei Zou;Zhiyin Xiao;Xiao Juan Huang;Zongyi Qin;Rujia Zou;Junqing Hu;;A Novel Photothermal Nanocrystals of Cu_7S_4 Hollow Structure for Efficient Ablation of Cancer Cells[J];Nano-Micro Letters;2014年02期

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本文編號：2073806