本文選題：膠原蛋白 + 外延生長��； 參考：《分析化學(xué)》2017年04期

【摘要】：膠原蛋白纖維與同樣具有周期性結(jié)構(gòu)表面的羥磷灰石等礦物質(zhì)晶體能夠通過多種作用在介觀尺度上相互識別,從而有效地進(jìn)行規(guī)范骨骼、牙齒等器官生長的生物礦化。在本研究中,反相利用生物礦化原理,開發(fā)出一種與熱壁外延生長(Hot wall epitaxy)技術(shù)效果相似的生物大分子納米線陣列的簡單制備技術(shù),成功地將5~10μg/m L的天然I型鼠尾膠原蛋白單體溶液在云母晶體的(001)晶面上培育成取向單一且長程有序的膠原蛋白納米線陣列。原子力顯微鏡實(shí)驗(yàn)結(jié)果表明,納米線陣列隨膠原蛋白單體濃度增大而變得致密,但是單條納米線的寬度與高度較為穩(wěn)定,分別約為60.0和1.5 nm。有納米線覆蓋的云母晶面親水性好,晶面接觸角由25.8°降為9.5°�；陔娮颖趁嫔⑸溲苌浜屯干潆娮语@微鏡的分析表征結(jié)果,納米線的取向應(yīng)沿云母[ˉ~110]方向,更詳實(shí)地驗(yàn)證了膠原蛋白納米線的準(zhǔn)外延生長機(jī)理。
[Abstract]:Collagen fibers and mineral crystals such as hydroxyapatite, which also have periodic structures, can be recognized on mesoscopic scales through various interactions, thus effectively biomineralizing the growth of bone, teeth and other organs. In this study, using the principle of biomineralization, a simple fabrication technique of biomolecular nanowire arrays was developed, which is similar to that of hot-wall epitaxial growth wall arrays. The natural rat tail collagen monomer solution of 5 渭 g / mL was successfully grown on the crystal plane of mica crystal to form a single and long term ordered collagen nanowire array. Atomic force microscopy (AFM) results showed that the nanowires became compact with the increase of collagen monomer concentration, but the width and height of the single nanowires were stable, about 60.0 and 1.5 nm, respectively. The mica crystal surface covered by nanowires has good hydrophilicity, and the contact angle of the crystal plane is reduced from 25.8 擄to 9.5 擄. Based on the analysis and characterization of electron backscattering diffraction and transmission electron microscope, the orientation of nanowires should be along the direction of mica. The quasi-epitaxial growth mechanism of collagen nanowires is verified in detail.
【作者單位】： 南京理工大學(xué)電子工程與光電技術(shù)學(xué)院;
【基金】：國家自然科學(xué)基金(No.51303082) 中央高�；究蒲袠I(yè)務(wù)費(fèi)專項(xiàng)資金(No.30915011316) 江蘇省“高層次創(chuàng)新創(chuàng)業(yè)人才引進(jìn)計(jì)劃”項(xiàng)目資助~~
【分類號】：TB383.1

【相似文獻(xiàn)】

相關(guān)期刊論文 前10條

1 王敬,熊貴光;金屬納米線陣列的光學(xué)非線性增強(qiáng)因子的分析和計(jì)算[J];光子學(xué)報(bào);2004年02期

2 牛宇然;張輝;陳子瑜;黃沛霖;武哲;;鈷鉑納米線陣列的制備與性能研究[J];電子顯微學(xué)報(bào);2006年06期

3 陳東;宋國君;彭智;佘希林;李建江;韓萍;;簡單蝕刻法制備具有可控高度的金屬納米線陣列[J];功能材料與器件學(xué)報(bào);2007年04期

4 劉建華;;不同結(jié)構(gòu)鎳納米線陣列的制備及其磁性[J];功能材料信息;2007年05期

5 韓萍;宋國君;徐思亭;孫桂濱;袁芳;韓云海;;電化學(xué)模板法制備金屬Ni納米線陣列的研究[J];青島大學(xué)學(xué)報(bào)(工程技術(shù)版);2008年02期

6 張軼群;施毅;濮林;張榮;鄭有p，

本文編號：1973631