本文選題：皮克林乳液 + 殼聚糖/TPP納米粒子��； 參考：《江南大學》2015年碩士論文

【摘要】：利用天然來源的生物材料合成納米粒子及其穩(wěn)定的皮克林乳液在食品和化妝品領(lǐng)域中具有重要的意義。殼聚糖(CS)是自然界中存在的唯一陽離子堿性多糖,其來源廣泛,氨基的存在賦予了殼聚糖許多獨特的理化性質(zhì),如生物可降解性,生物相容性等,本文對殼聚糖/TPP納米粒子和殼聚糖/海藻酸鈉納米粒子的合成以及其乳化穩(wěn)定石蠟/水乳液的乳化性能,穩(wěn)定機理和化妝品的應用作了系統(tǒng)的研究。采用三聚磷酸鈉(TPP)為交聯(lián)劑,通過離子凝膠法制備了殼聚糖/TPP納米粒子,該方法無需有機溶劑,制備條件溫和,通過控制不同的反應條件,制備了不同粒徑的CS/TPP納米粒子,以制備穩(wěn)定好,粒徑小的納米粒子為目的,得出制備的最佳工藝條件為:殼聚糖濃度為1.5 mg/m L,TPP濃度為0.65 mg/m L,殼聚糖與TPP質(zhì)量比為5:1,殼聚糖溶液p H為4.2。對納米粒子穩(wěn)定性分析表明粒子具有很好的穩(wěn)定性,通過掃描電鏡觀察發(fā)現(xiàn)所制備的殼聚糖納米球球形較好,粒徑分布均一,CS/TPP納米粒子可以乳化液體石蠟制得O/W乳液,這種粒子穩(wěn)定的乳液具有優(yōu)異的抗凝聚性能。研究了影響乳液的各因素,增加顆粒濃度,乳析穩(wěn)定性越好,液滴粒徑越小,通過調(diào)節(jié)分散相p H值和Na Cl濃度成功地制備了均一穩(wěn)定的乳液。乳液的流變性分析表明隨著顆粒濃度的增大乳液黏度更高,乳液表現(xiàn)更強的彈性行為,乳液的熒光顯微鏡觀察揭示了顆粒在油水界面處的吸附,有效阻止了液滴的聚結(jié)從而穩(wěn)定乳液。CS/TPP納米粒子在化妝品膏霜類配方中乳化穩(wěn)定的乳液具有很好的耐熱性、耐寒性、離心穩(wěn)定性,相比表面活性劑穩(wěn)定的乳液具有更好的膚感。用帶相反電荷的海藻酸鈉(ALG)通過靜電相互作用制備了殼聚糖/海藻酸鈉納米粒子,研究了殼聚糖分子量和脫乙酰度、氯化鈣濃度、殼聚糖濃度、殼聚糖溶液和海藻酸鈉溶液的p H對粒子粒徑和電位的影響,結(jié)果得到制備120 nm左右的納米粒子的最佳條件:m(ALG):m(Ca Cl2):m(CS)=5:1:1.5,殼聚糖溶液p H為5.4,海藻酸鈉溶液p H為5.2。用殼聚糖/海藻酸鈉納米粒子穩(wěn)定乳化皮克林乳液,當濃度達到1%即能制備穩(wěn)定乳液,0.8%CS/ALG納米粒子穩(wěn)定的乳液在油相體積為0.65發(fā)生轉(zhuǎn)相,1.5%納米粒子穩(wěn)定的乳液在0.75發(fā)生轉(zhuǎn)相,并且CS/ALG納米粒子穩(wěn)定的乳液相比相同顆粒濃度下CS/TPP納米粒子穩(wěn)定的乳液轉(zhuǎn)相點更高。CS/ALG納米粒子穩(wěn)定的乳液有比較寬的p H范圍,通過Na Cl濃度影響乳液乳化性的分析表明電解質(zhì)可以改變顆粒表面的潤濕性。CS/ALG納米粒子在化妝品膏霜類配方中乳化穩(wěn)定的乳液具有很好的耐熱性、耐寒性和離心穩(wěn)定性,與CS/TPP凝膠納米粒子穩(wěn)定的乳液相比其用量更少,乳化性更強,同時穩(wěn)定的乳液黏度更高,涂感清爽不油膩,保濕性更好。
[Abstract]:The synthesis of nanoparticles and their stable Pickering emulsion from natural biomaterials is of great significance in the field of food and cosmetics. Chitosan (CSN) is the only cationic alkaline polysaccharide that exists in nature. The presence of amino groups endows chitosan with many unique physicochemical properties, such as biodegradability, biocompatibility, etc. In this paper, the synthesis of chitosan / TPP nanoparticles and chitosan / sodium alginate nanoparticles as well as the emulsification properties, stabilization mechanism and application of cosmetics were systematically studied. Chitosan / TPP nanoparticles were prepared by ionic gel method using sodium tripolyphosphate (TPP) as crosslinker. In this method, CS/TPP nanoparticles with different particle sizes were prepared by controlling different reaction conditions and without organic solvent. In order to prepare stable and small nanoparticles, the optimum preparation conditions were obtained as follows: chitosan concentration was 1.5 mg/m / L TPP concentration was 0.65 mg/m / L, the mass ratio of chitosan to TPP was 5: 1, and pH of chitosan solution was 4.2. The analysis of the stability of nanoparticles shows that the nanoparticles have good stability. By scanning electron microscope, we found that the chitosan nanospheres prepared are better spherical, and the size distribution of CS- / TPP nanoparticles can emulsify paraffin wax to prepare the O / W emulsion. This kind of particle stable emulsion has excellent anti-agglomeration property. The factors affecting the emulsion were studied. The better the emulsion stability was, the smaller the droplet size was. The homogeneous stable emulsion was successfully prepared by adjusting the pH value of dispersed phase and the concentration of NaCl. The rheological analysis of the emulsion shows that with the increase of the particle concentration, the viscosity of the emulsion is higher and the emulsion exhibits a stronger elastic behavior. The fluorescence microscope observation of the emulsion reveals the adsorption of the particles at the oil-water interface. It can effectively prevent droplet coalescence and stabilize the emulsion. CS- / TPP nanoparticles have good heat resistance, cold resistance and centrifugal stability in the formula of cosmetics cream. The emulsion has better skin feeling than surfactant stable emulsion. Chitosan / sodium alginate nanoparticles were prepared by electrostatic interaction with alginate with opposite charge. The molecular weight and deacetylation degree of chitosan, the concentration of calcium chloride and the concentration of chitosan were studied. The effects of pH in chitosan solution and sodium alginate solution on particle size and potential were obtained. The optimum conditions for preparation of nano-particles about 120 nm were obtained. The optimum conditions for preparation of nanoparticles were obtained. The optimum conditions for preparation of nano-particles were as follows: 1: 1: 1.5, 5: 1: 1.5, 5.4 for chitosan solution, 5.2 for sodium alginate solution, and 5: 1: 1.5 for sodium alginate solution. Chitosan / sodium alginate nanoparticles were used to stabilize the emulsified Pickering emulsion. When the concentration reached 1%, the stable emulsion with 0.8CS / ALG nanoparticles could be prepared, and the emulsion with the oil phase volume of 0.65 and the emulsion with 1.5% nano-particle stability could be phase-shifted at 0.75. And the stable emulsion of CS/ALG nanoparticles has a wider pH range than the stable emulsion with CS/TPP nanoparticles at the same concentration. The analysis of the influence of NaCl concentration on emulsion emulsification shows that electrolyte can change the wettability of particle surface. CSP / ALG nanoparticles have good heat resistance, cold resistance and centrifugal stability in the formula of cosmetics cream. Compared with the stable emulsion of CS/TPP gel nanoparticles, its dosage is less, its emulsification is stronger, and the stable emulsion has higher viscosity, freshness and no greasy coating, and better moisturizing property.
【學位授予單位】：江南大學
【學位級別】：碩士
【學位授予年份】：2015
【分類號】：O636.1;TB383.1

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