本文選題：液滴微流控 + 微通道并行�。� 參考：《華東理工大學(xué)》2017年碩士論文

【摘要】：微流控技術(shù)在制備功能材料方面極具效率性和優(yōu)勢(shì)性,但是目前一直局限在實(shí)驗(yàn)室規(guī)模,制約著其產(chǎn)業(yè)化應(yīng)用。本文基于微通道并行概念,圍繞微通道并行放大規(guī)律以及微通道制造加工兩條主線展開研究,旨在實(shí)現(xiàn)規(guī)�；苽涔δ懿牧系哪繕�(biāo)。本文創(chuàng)新性提出了多級(jí)模塊化的微通道放大策略,并基于流阻模型建立了三維復(fù)雜分支管網(wǎng)的壓力平衡模型,推導(dǎo)出模塊的設(shè)計(jì)準(zhǔn)則,揭示了放大參數(shù)、分配均勻性和通道設(shè)計(jì)參數(shù)之間的內(nèi)在聯(lián)系。在放大規(guī)律理論的指導(dǎo)下,基于激光雕刻技術(shù)以PMMA材料作為基板加工了八個(gè)通道陣列、十個(gè)陣列堆疊、五個(gè)堆疊模塊集成的微流控放大系統(tǒng),實(shí)現(xiàn)液滴微流控技術(shù)三級(jí)放大及規(guī)�；苽渚鶆蛞旱蔚哪繕�(biāo)。同時(shí),研究了通道陣列放大和陣列堆疊放大所產(chǎn)生的放大效應(yīng)。以殼聚糖體系為例,規(guī)�；苽淞宋⒚准�(jí)的殼聚糖微球,在提升產(chǎn)量的同時(shí)保持了良好的單分散性。同時(shí)探索新型3D打印技術(shù)在成型微通道方面的應(yīng)用。成型了三維結(jié)構(gòu)微通道,驗(yàn)證了液滴制備與表面濕潤(rùn)特性無(wú)關(guān)性。采用數(shù)值模擬的方法研究了在重力作用下流體的分配性能,并以此作為指導(dǎo),設(shè)計(jì)并3D打印了八通道豎直并行的微流控模塊,實(shí)現(xiàn)了多通道并行規(guī)�；苽湟旱蔚哪繕�(biāo)。以海藻酸鈉體系為例,規(guī)�；苽淞撕Ｔ逅徕}微球。
[Abstract]:Microfluidic technology has high efficiency and superiority in the preparation of functional materials, but at present, it is limited in the scale of laboratory, which restricts its industrial application. Based on the concept of microchannel parallelism, this paper focuses on the microchannel parallel amplification law and microchannel manufacturing and processing, in order to achieve the goal of large-scale preparation of functional materials. In this paper, a multi-level modularized microchannel amplification strategy is proposed. Based on the flow resistance model, the pressure balance model of a three-dimensional complex branch pipe network is established, the design criteria of the module are derived, and the amplification parameters are revealed. The relationship between distribution uniformity and channel design parameters. Under the guidance of the amplification law theory, based on the laser engraving technology, the microfluidic amplification system with eight channel arrays, ten arrays stacked and five stacking modules is fabricated with PMMA material as the substrate. To achieve the goal of three-stage amplification and large-scale preparation of uniform droplets by droplet microfluidic technology. At the same time, the amplification effects of channel array amplification and array stacking amplification are studied. Taking chitosan system as an example, micrometer chitosan microspheres were prepared on a large scale, which kept good monodispersity while increasing yield. At the same time, the application of new 3D printing technology in shaping microchannel is explored. Three-dimensional microchannels were formed to verify that the preparation of droplets was independent of surface wetting characteristics. The distribution performance of fluid under gravity is studied by numerical simulation. Based on this, an eight-channel vertical parallel microfluidic control module is designed and 3D printed, which realizes the goal of multi-channel parallel large-scale preparation of droplets. Calcium alginate microspheres were prepared on a large scale with sodium alginate as an example.
【學(xué)位授予單位】：華東理工大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：TB34

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