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  本文選題：功能化磁性納米材料 + 吸附��； 參考：《沈陽理工大學(xué)》2015年碩士論文

【摘要】：氧化石墨烯和碳納米管具有易功能化修飾,比表面積大等優(yōu)點(diǎn)�？梢杂行У膶λ幬镞M(jìn)行吸附、負(fù)載并進(jìn)行靶向運(yùn)輸,可以用在藥物主要成分的分析、抗癌藥物的負(fù)載和藥緩釋等方面。本論文致力于將氧化石墨烯和碳納米管進(jìn)行功能化修飾,制備具有良好吸附性能的磁性納米材料,并考察其藥物負(fù)載及分析性能。(1)通過Hummers法制備氧化石墨烯(GO),水熱法制備氨基化四氧化三鐵(NH2-Fe3O4),通過對GO的功能化修飾制備出氨基化四氧化三鐵氧化石墨烯磁性納米材料(NH2-Fe3O4/GO)。并使用SEM、XRD、FT-IR和VSM對其形貌,結(jié)構(gòu)等進(jìn)行分析,并考察了NH2-Fe3O4/GO對四環(huán)素的吸附性能。結(jié)果表明在p H=5.0,吸附時間為75min,NH2-Fe3O4/GO加入量為6.0mg時,吸附容量為31mg/g,吸附率在95%以上,且低溫更有利于提高吸附效果。使用濃度為0.30mol/L的硼酸鈉溶液作為洗脫液,洗脫率達(dá)到96%以上,并用于實(shí)際樣品中四環(huán)素的分析。(2)將鹽酸多巴胺修飾在NH2-Fe3O4/GO表面,制備氨基化四氧化三鐵氧化石墨烯@多巴胺(NH2-Fe3O4/GO@PDA)功能材料。使用SEM、XRD、FT-IR和VSM等表征手段對所制備的材料進(jìn)行表征,并考察了NH2-Fe3O4/GO@PDA對環(huán)丙沙星的吸附性能。結(jié)果表明,最佳吸附條件為:p H為7.0,吸附時間為70min,吸附劑用量為3.0mg時,吸附容量為43.48mg/g。使用0.6mol/L鹽酸為洗脫液,洗脫率大于96%,并將所制備的NH2-Fe3O4/GO@PDA用于實(shí)際樣品中環(huán)丙沙星含量的分析。(3)采用水熱法制備出磁多壁碳納米管(m-MWCNTs),并用鹽酸多巴胺將其功能化修飾,制備出磁多壁碳納米管@鹽酸多巴胺(m-MWCNTs@PDA)磁性功能材料。并使用各種表征手段對其形貌,結(jié)構(gòu)進(jìn)行分析,所制備的材料表面光滑,粒徑分布均勻并且具有超順磁性,考察m-MWCNTs@PDA對槲皮素的負(fù)載性能,在最佳負(fù)載條件下,負(fù)載容量為36.63mg/g,負(fù)載率可達(dá)到94%以上。使用0.20mol/L的氫氧化鈉溶液作為洗脫液,洗脫率高于98%,m-MWCNTs@PDA-槲皮素載藥體系可以持續(xù)釋放藥物15h以上。
[Abstract]:Graphene oxide and carbon nanotubes with easy functionalization, large surface area etc.. Can effectively adsorb drug load and targeted transport, analysis can be used in the main components of drugs, anticancer drugs and drug load and so on. This paper is devoted to the graphene oxide and carbon nanotubes the function of modified magnetic nano material preparation has good adsorption properties, and investigate the drug load and performance analysis. (1) the preparation of graphene oxide by Hummers method (GO), hydrothermal synthesis of amino functionalized Fe3O4 (NH2-Fe3O4), through the modification of GO prepared by amination of Fe3O4 oxide graphene nano magnetic material (NH2-Fe3O4/GO). And the use of SEM, XRD, FT-IR and VSM on the morphology, structure analysis, and the effects of NH2-Fe3O4/GO on the adsorption of tetracycline. The results show that in P H=5.0, adsorption time For 75min, the addition amount of NH2-Fe3O4/GO is 6.0mg, the adsorption capacity of 31mg/g, the adsorption rate was above 95%, and low temperature is beneficial to the improvement of adsorption effect. The use of concentration of sodium borate solution 0.30mol/L as the eluent, elution rate reached more than 96%, and for the analysis of tetracycline in real samples. (2) will be modified in dopamine hydrochloride the surface of NH2-Fe3O4/GO, preparation of aminated graphene oxide Fe3O4 @ dopamine (NH2-Fe3O4/GO@PDA) functional materials. The use of SEM, XRD, of the prepared materials were characterized by FT-IR and VSM techniques, and the effects of NH2-Fe3O4/GO@PDA on adsorption of ciprofloxacin. The results showed that the optimum adsorption conditions were as follows: P H was 7, adsorption time 70min, adsorbent dosage was 3.0mg, the adsorption capacity of 43.48mg/g. using 0.6mol/L hydrochloric acid as eluent, elution rate greater than 96%, and the NH2-Fe3O4/GO@PDA prepared for actual samples in Analysis of ciprofloxacin content. (3) prepared by hydrothermal method magnetic multi walled carbon nanotubes (m-MWCNTs), and its modification with dopamine hydrochloride, preparation of magnetic MWNTs @ dopamine hydrochloride (m-MWCNTs@PDA) magnetic functional material. And use the various characterization methods on the morphology, structure analysis the surface preparation materials, smooth, uniform particle size distribution and superparamagnetism, load performance of m-MWCNTs@PDA was investigated in quercetin, optimum load condition, the load capacity of 36.63mg/g, the load rate can reach more than 94%. The use of 0.20mol/L sodium hydroxide solution as the eluent, elution rate is higher than 98% m-MWCNTs@PDA-, quercetin as drug delivery system can sustained release drug 15h.

【學(xué)位授予單位】：沈陽理工大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2015
【分類號】：TB34;TQ460.1

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本文編號：1763764