本文選題：摻雜 + 碳量子點(diǎn)　； 參考：《西南大學(xué)》2017年碩士論文

【摘要】：碳量子點(diǎn)(carbon dots)是一種新型的熒光納米顆粒,由于其具有很多諸如熒光穩(wěn)定性好、毒性低、生物相容性高、化學(xué)性質(zhì)穩(wěn)定等優(yōu)點(diǎn),已經(jīng)引起研究者的廣泛關(guān)注。為了開發(fā)出一些具有特殊功能的碳量子點(diǎn),研究者投入了大量的精力和時(shí)間研究新型的碳量子點(diǎn),然后利用其表面豐富的官能團(tuán)進(jìn)行一些特異性的檢測(cè)以及其它應(yīng)用。近年來,研究者已經(jīng)掌握了碳量子點(diǎn)的基本光學(xué)性質(zhì),組成結(jié)構(gòu)以及其應(yīng)用潛力。但是它的形成過程和發(fā)光機(jī)理還不是特別清楚,這在一定程度上限制了它的應(yīng)用,因此還需要進(jìn)一步探索研究。雖然關(guān)于碳量子點(diǎn)的報(bào)道有很多,但是種類相對(duì)較少,且其發(fā)光范圍狹窄,合成種類需要進(jìn)一步擴(kuò)大,合成規(guī)律和機(jī)理還需要進(jìn)一步的深入研究,應(yīng)用領(lǐng)域需進(jìn)一步開拓和探索。摻雜作為一種改善材料性能簡單有效的方法,雜原子摻雜碳量子點(diǎn)能有效改善它的性能,比如熒光量子產(chǎn)率、發(fā)射光譜的范圍、具有一些特殊的功能等。本論文主要以不同的有機(jī)分子為前驅(qū)體,通過簡單的一步水熱法合成不同類型的雙雜原子摻雜的碳量子點(diǎn),研究它們?cè)诓煌瑮l件下的穩(wěn)定性以及用于離子的特異性檢測(cè)和細(xì)胞的熒光成像。具體內(nèi)容如下:1.以聚乙烯亞胺為氮源和4-甲�；脚鹚釣榕鹪�,通過一步簡單的水熱法合成硼、氮雙摻雜發(fā)射藍(lán)色熒光碳量子點(diǎn)(B/N-C-dots)。通過TEM表征,其粒徑范圍分布在3.7-4.7 nm很窄的范圍內(nèi),平均粒徑大約4.2 nm,形狀類似球形,水中分散性非常好。通過和單原子摻雜相比,硼、氮雙摻雜碳量子點(diǎn)熒光量子產(chǎn)率(15.85%)明顯高于氮摻雜碳量子點(diǎn)(1.55%)和硼摻雜碳量子點(diǎn)(3.91%)。通過XPS和FTIR表征可知碳量子點(diǎn)表面有大量官能團(tuán)(NH2/-COOH/-OH),并且對(duì)pH和溫度表現(xiàn)出雙重響應(yīng)性。除此之外,經(jīng)檢測(cè)該碳量子點(diǎn)對(duì)Fe~(3+)具有特異響應(yīng)性,考察了不同pH條件下B/N-C-dots對(duì)Fe~(3+)的選擇性。通過細(xì)胞成像和細(xì)胞毒性實(shí)驗(yàn)表明,該碳量子點(diǎn)的毒性低,可用于細(xì)胞的熒光成像。2.以檸檬酸為碳源和以胱胺為氮源和硫源,通過水熱法合成了氮、硫雙摻雜碳量子點(diǎn)(N,S/C-dots),其熒光量子產(chǎn)率高達(dá)39.7%。所得到的碳量子點(diǎn)通過TEM表征,其粒徑平均大小為1.7 nm,分散性很好,表面未經(jīng)進(jìn)一步的修飾或鈍化表現(xiàn)出極好的水溶性。通過XPS和FTIR表征表明,碳量子點(diǎn)表面含有豐富的官能團(tuán)。它的熒光非常的穩(wěn)定,在很寬的pH(3-12)和溫度范圍內(nèi)其熒光穩(wěn)定性良好。該碳量子點(diǎn)可用于特異性檢測(cè)重金屬六價(jià)鉻離子,研究了N,S/C-dots在不同條件下對(duì)六價(jià)鉻離子的選擇性檢測(cè)。除此之外,考察了N,S/C-dots用于細(xì)胞的多色成像以及細(xì)胞毒性,表現(xiàn)出低毒性和良好的生物相容性。
[Abstract]:Carbon Quantum Dots (QDs) is a new type of fluorescent nanoparticles. Because of its many advantages such as good fluorescence stability, low toxicity, high biocompatibility and stable chemical properties, it has attracted the attention of researchers.In order to develop some special functional carbon quantum dots, researchers have devoted a lot of time and energy to the study of new carbon quantum dots, and then used the abundant functional groups on their surface to carry out some specific detection and other applications.In recent years, researchers have mastered the basic optical properties, composition and application potential of carbon quantum dots.However, its formation process and luminescence mechanism are not very clear, which limits its application to some extent. Therefore, further research is needed.Although there have been many reports on carbon quantum dots, there are relatively few species, and their luminescence ranges are narrow, the synthetic species need to be further expanded, and the synthesis law and mechanism need to be further studied.The application field needs further development and exploration.Doping is a simple and effective method to improve the properties of materials. Hetero-atom doped carbon quantum dots can effectively improve its performance, such as fluorescence quantum yield, emission spectrum range, and have some special functions.In this thesis, different kinds of diatomic carbon quantum dots were synthesized by a simple hydrothermal method with different organic molecules as precursors.Their stability under different conditions and their specific detection of ions and fluorescence imaging of cells were studied.The details are as follows: 1.Boron was synthesized by a simple hydrothermal method using polyethylene imine as nitrogen source and 4-formyl phenylboric acid as boron source.The TEM results show that the particle size distribution is very narrow in the range of 3.7-4.7 nm, the average particle size is about 4.2 nm, the shape is similar to the spherical shape, and the dispersion in water is very good.Compared with monatomic doping, the fluorescence quantum yield of boron, nitrogen-doped carbon quantum dots (~ 15.85) is significantly higher than that of nitrogen doped carbon quantum dots (1.55) and boron-doped carbon quantum dots (3.91%).The results of XPS and FTIR show that there are a large number of functional groups on the surface of carbon quantum dots NH _ 2 / -COOH _ (-OH) _ (-OH _ (2)), and they are double responsive to pH and temperature.In addition, the specific response of the QDs to Fe~(3 was detected, and the selectivity of B/N-C-dots to Fe~(3 at different pH was investigated.The results of cell imaging and cytotoxicity test showed that the carbon quantum dot had low toxicity and could be used in fluorescence imaging of cells. 2.Nitrogen was synthesized by hydrothermal method using citric acid as carbon source and cysteamine as nitrogen source and sulfur source.The carbon quantum dots were characterized by TEM. The average size of the QDs was 1.7 nm, the dispersion of the QDs was very good, and the surface showed excellent water solubility without further modification or passivation.The results of XPS and FTIR show that there are abundant functional groups on the surface of carbon quantum dots.Its fluorescence is very stable and has good stability in the wide pH range of 3-12) and temperature.The carbon quantum dots can be used for the specific detection of hexavalent chromium ions. The selective detection of hexavalent chromium ions under different conditions has been studied.In addition, the polychromatic imaging and cytotoxicity of NPS / C-dots were investigated, showing low toxicity and good biocompatibility.
【學(xué)位授予單位】：西南大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：O613.71;TB383.1

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