發(fā)布時間：2018-03-25 19:15

  本文選題：熒光量子點　切入點：磁性納米粒子　出處：《濟(jì)南大學(xué)》2015年碩士論文

【摘要】：隨著納米科學(xué)技術(shù)的發(fā)展,科學(xué)工作者們已經(jīng)成功制備出具有獨特電、磁、光、熱、生物、化學(xué)等性能的功能性納米顆粒。這些功能性納米顆粒對于生物、醫(yī)學(xué)、電子、化學(xué)、材料等許多學(xué)科領(lǐng)域的發(fā)展具有重大意義,其中熒光量子點和磁性納米材料因其優(yōu)良的發(fā)光性能和磁學(xué)性能,在生物醫(yī)學(xué)領(lǐng)域具有廣泛應(yīng)用。然而,隨著科學(xué)技術(shù)的進(jìn)一步發(fā)展,單一功能的材料已經(jīng)不再滿足人們對先進(jìn)材料的需求,因此,如果將磁性和熒光相結(jié)合,集分離和標(biāo)記功能于一體,通過一定的物理化學(xué)工藝制備出多功能磁性熒光納米復(fù)合材料,使其可以作為熒光探針的同時,還具有良好的磁靶向性。基于此,本課題采用具有核磁共振造影劑作用的超順磁性Fe3O4@SiO2為磁核提供磁性,以顏色可調(diào)、高發(fā)光效率的核殼結(jié)構(gòu)的ZnSe@ZnS量子點提供熒光,通過微乳液法制備同時包埋磁性納米粒子和熒光量子點的Si02微粒,實現(xiàn)磁性熒光雙功能復(fù)合。這種復(fù)合納米材料不僅拓展了其生物醫(yī)學(xué)應(yīng)用潛力,還能有效克服磁性四氧化三鐵納米粒子易被氧化、量子點對周圍環(huán)境的敏感性及生物毒性等問題,使兩種納米粒子的應(yīng)用范圍進(jìn)一步擴(kuò)大。此外,為了完善Fe3O4@SiO2磁性納米粒子的性能,采用化學(xué)還原法在其表面沉積一層銀單質(zhì),旨在制備出具有核殼結(jié)構(gòu)的MNPs/Ag磁性粒子。將貴金屬納米材料覆蓋到磁性納米材料表面,可以大幅改良原磁性納米顆粒的穩(wěn)定性,同時其本身的獨特性質(zhì)也能結(jié)合到復(fù)合材料中,這可以一定程度上拓展納米材料的實用性。銀納米顆粒在可見光區(qū)和近紅外光區(qū)的等離子體共振特性使得銀納米顆粒具有較高的光催化性能、殺菌作用、表面增強(qiáng)光譜、光學(xué)性能等,同時相對于金屬金、鈕、鈾而言,金屬銀的價格較低,因此磁性納米粒子與貴金屬Ag的復(fù)合具有研究價值。本論文采用微乳液法制備磁性熒光雙功能復(fù)合顆粒,以環(huán)己烷為連續(xù)相,TriotnX-100為表面活性劑,正己醇為助活性劑,體積比為4：1：1時,可得到適于反應(yīng)的微乳液,通過紫外吸收光譜和熒光光譜分析得到最佳制備工藝參數(shù)為：當(dāng)量子點與磁性粒子的摩爾比為5：1,TEOS和氨水的體積分?jǐn)?shù)分別2.2%和3.2%,反應(yīng)時間為24h時,所制備磁性熒光雙功能復(fù)合顆粒的性能最好。制備的磁性熒光復(fù)合顆粒基本呈球形,粒徑大小在70nm左右,穩(wěn)定性良好,其抗光漂白性能相比于量子點有所增強(qiáng),可放置很長一段時間,并且表現(xiàn)出良好的超順磁性。本論文采用微乳液法制備的Fe3O4@SiO2磁性粒子顆粒基本成球形,分散性良好,粒徑大小在40nm左右。Fe3O4@SiO2磁性粒子表現(xiàn)出良好的超順磁性,但比純Fe304磁性粒子的性能有所降低。本論文采用化學(xué)還原法在Fe3O4@SiO2磁性粒子表面沉積一層薄的Ag殼層,粒徑大小改變不大,顆粒仍呈球形,分散性良好。MNPs/Ag磁性粒子表現(xiàn)出良好的超順磁性,同時由于Ag殼層比較薄,其磁性能接近于Fe3O4@SiO2磁性粒子,并且Fe3O4@SiO2與AgNO3的摩爾比為1：0.4時制備的MNPs/Ag中Ag的重量百分比較大為6.39。
[Abstract]:With the development of nano science and technology, scientists have successfully prepared with unique electrical, magnetic, optical, thermal, biological, chemical and other properties of functional nanoparticles. These functional nanoparticles for biological, medical, electronic, chemical, material and other fields of many disciplines development is of great significance, including fluorescence quantum dots and magnetic nano materials because of its excellent luminescent properties and magnetic properties, is widely used in the biomedical field. However, with the further development of science and technology, single function material no longer meet the needs of people of advanced materials so that if the magnetic and fluorescent combination, set the isolation and labeling functions. Through physical and chemical process prepared by multifunctional magnetic fluorescent nanometer composite material, which can be used as a fluorescent probe at the same time, also has good magnetic targeting. Based on this, this lesson The problem with magnetic resonance imaging agent superparamagnetic magnetic Fe3O4@SiO2 as magnetic core, with adjustable color, ZnSe@ZnS quantum dots core-shell structure with high light-emitting efficiency and provide fluorescence by Si02 particles prepared by microemulsion method and embedding of magnetic nanoparticles and quantum dots, magnetic fluorescent bifunctional compound. Nano composite material not only expand its biomedical application potential, can effectively overcome the magnetic Fe3O4 nanoparticles are easily oxidized, quantum dots on environment sensitivity and biological toxicity and other issues, the two kinds of nano particles to further expand the scope of application. In addition, in order to improve the performance of Fe3O4@SiO2 magnetic nanoparticles by chemical reduction method, deposited on the surface of a layer of silver, in order to prepare MNPs/Ag magnetic particles with core-shell structure. The noble metal nano materials covered by magnetic nano materials The surface of the material can be greatly improved the stability of magnetic nanoparticles, and its unique properties can also be combined in composite materials, the practicability of this can to some extent development of nanomaterials. The silver nanoparticles in the plasma resonance characteristics of visible and near infrared region of the silver nanoparticles with high photocatalytic properties. Bactericidal effect, surface enhanced spectroscopy, optical properties, and compared with the metal button, gold, uranium, silver's price is low, so the composite has the research value of magnetic nanoparticles and noble metal Ag. Microemulsion preparation of magnetic fluorescent bifunctional composite particles used in this paper, by using cyclohexane as continuous phase, TriotnX-100 surface surfactant, hexanol as co surfactant, the volume ratio of 4:1:1, can be obtained for microemulsion reaction analysis, get the best preparation by UV Vis absorption spectra and fluorescence spectra The preparation process parameters: when the molar ratio of quantum dots and magnetic particles is 5:1, the volume fraction of TEOS and ammonia were 2.2% and 3.2%, the reaction time is 24h, the performance of preparation of magnetic fluorescent bifunctional composite particles. The best magnetic fluorescent composite particles prepared basically spherical particle size, good stability in 70nm so, photobleaching resistance compared to quantum dots has been enhanced, can be placed for a long period of time, and showed good superparamagnetism. This paper uses Fe3O4@SiO2 magnetic particles prepared by microemulsion was basically spherical and well dispersed, the particle size of.Fe3O4@SiO2 was about 40nm magnetic particles showed good the superparamagnetic properties of pure Fe304, but the ratio of magnetic particles decreased. This paper adopts the chemical reduction method Fe3O4@SiO2 magnetic particles deposited on the surface of a thin layer of Ag shell, the particle size did not change, still particles Spherical, well dispersed.MNPs/Ag nanoparticles exhibit good superparamagnetism, and because the Ag shell is very thin, close to the magnetic properties of Fe3O4@SiO2 magnetic particles, and the molar ratio of Fe3O4@SiO2 and AgNO3 1:0.4 MNPs/Ag prepared Ag weight percent larger for 6.39.

【學(xué)位授予單位】：濟(jì)南大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2015
【分類號】：TB383.1

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