本文關(guān)鍵詞： 木薯醋酸酯淀粉 果膠 卡拉膠 膜材　出處：《聊城大學(xué)》2017年碩士論文　論文類型：學(xué)位論文

【摘要】：傳統(tǒng)的空心膠囊是以動物膠-明膠為膜材,已經(jīng)具有百年的歷史。但隨著醫(yī)藥品種的增加和技術(shù)的進步,明膠膠囊的弊端逐漸顯現(xiàn)。近年來,尋找明膠替代品成為膠囊研究的熱點,其中以植物來源的多糖類物質(zhì)如海藻酸鈉、變性淀粉作為膜材成為研究的重點。本文選用木薯醋酸酯淀粉、玉米淀粉、卡拉膠和果膠等天然植物材料,分別制備了普通型和pH依賴型植物復(fù)合膜材,研究了膜材性能以及對藥物釋放的影響。主要研究內(nèi)容如下:1.卡拉膠植物淀粉復(fù)合膜的制備采用木薯醋酸酯淀粉、玉米淀粉和卡拉膠復(fù)配制備植物空心膠囊成膜材料。首先分別研究了木薯醋酸酯淀粉、玉米淀粉和卡拉膠的濃度-粘度-溫度關(guān)系、溶解度、膨脹率等性能;基于差式掃描量熱分析和成膜性分析確定了木薯變性淀粉、玉米淀粉和卡拉膠三種配比,測定三種膜的透光率、水蒸氣透過率和吸濕率等性能。結(jié)果表明醋酸酯淀粉對膜各種參數(shù)影響顯著,隨著醋酸酯淀粉所占比例的增大,膜的吸濕性和水蒸氣透過率隨之增大。2.pH依賴型植物高分子膜的制備及性能研究選用pH敏感型的果膠與木薯醋酸酯變性淀粉與卡拉膠復(fù)配制備pH依賴型天然高分子膜,研究了膜材料的性能。以膜斷裂伸長率作為評價指標,正交優(yōu)化復(fù)合膜組分配比,并對復(fù)合膜進行了透光性、吸濕性和水蒸氣透過等性能測試。結(jié)果表明,三種組分中卡拉膠對膜性能影響最大,包括斷裂伸長率和水蒸氣透過系數(shù)2個關(guān)鍵膜性能指標,果膠主要影響復(fù)合膜的透光率,最優(yōu)的復(fù)合膜組方為卡拉膠3%,醋酸酯淀粉3%,果膠1%。3.pH依賴型植物基微膠囊的制備和體外釋藥研究為研究新型腸溶植物基微膠囊,實現(xiàn)消化道定位給藥,以植物多糖變性淀粉、果膠和卡拉膠為基質(zhì),制備了微膠囊并考察了其性質(zhì)、體外釋藥行為和安全性。選用果膠、木薯醋酸酯淀粉與卡拉膠為材料,制備了pH依賴型微膠囊�？疾炝宋⒛z囊的紅外吸收特征、溶解性能、顯微結(jié)構(gòu)和細胞毒性,并進一步研究了微膠囊的釋藥行為。結(jié)果表明:當微膠囊中不含果膠時,其在不同pH條件下均不溶解且沒有藥物釋放;當基質(zhì)中果膠含量為1%,pH在中性偏酸性時微膠囊的釋藥量最大,隨著果膠濃度的增大微膠囊的釋藥量降低,3%果膠含量微膠囊?guī)缀鯖]有釋藥。細胞毒性結(jié)果表明微膠囊是安全無毒的。果膠是pH依賴型微膠囊的關(guān)鍵成分,通過調(diào)節(jié)果膠含量可以實現(xiàn)微膠囊在pH中性環(huán)境下的有效釋藥,實現(xiàn)藥物在腸道的定位釋放,提高藥物的生物利用度。4.空心膠囊的質(zhì)量評價和穩(wěn)定性研究選用羥丙基淀粉空囊與明膠空心膠囊兩種空囊,依照《中國藥典》2015年版的要求進行性能測定。將兩種膠囊分別裝載酸堿兩種藥物,載藥后對膠囊在高溫、高濕、高管照條件下的穩(wěn)定性及溶出度情況進行測定。結(jié)果表明,淀粉空囊與明膠空心膠囊的性能相當。
[Abstract]:Traditional hollow capsules are made of animal gelatin and gelatin, which has a history of 100 years. But with the increase of medicine variety and the progress of technology, the disadvantages of gelatin capsules appear gradually in recent years. Finding a substitute for gelatin has become the focus of the capsule research, in which plant derived polysaccharides such as sodium alginate, modified starch as membrane materials become the focus of the study. This paper selected cassava acetate starch, corn starch. Natural plant materials, such as carrageenan and pectin, were used to prepare common and pH dependent plant composite membranes, respectively. The main contents of the study were as follows: 1. Cassava acetate starch was used as the preparation of carrageenan plant starch composite membrane. Corn starch and carrageenan were mixed to prepare plant hollow capsule film-forming materials. Firstly, the concentration-viscosity temperature relationship, solubility and expansion rate of cassava acetate starch, corn starch and carrageenan were studied respectively. Based on differential scanning calorimetry and film forming analysis, the ratio of cassava modified starch, corn starch and carrageenan was determined, and the transmittance of the three films was measured. The results showed that the effect of acetate starch on the membrane parameters was significant with the increase of the proportion of starch acetate. Hygroscopicity and water vapor transmittance of the membranes increased. 2. Preparation and properties of pH-dependent plant polymer membranes; Pectin, cassava acetate modified starch and carrageenan were mixed with pH-sensitive pectin and cassava acetate modified starch and carrageenan to prepare pH dependent polymer membranes. Natural polymer membrane. The properties of the composite films were studied. The elongation at break was taken as the evaluation index, the distribution ratio of composite films was optimized by orthogonal method, and the transmittance, moisture absorption and water vapor permeability of the composite films were tested. Carrageenan had the greatest influence on the membrane properties, including the elongation at break and the water vapor transmittance. Pectin mainly affected the transmittance of the composite membrane. The optimum compound membrane was carrageenan 3, acetate starch 3and pectin 1.3.The preparation and in vitro release of pH-dependent plant-based microcapsules were used to study the new enteric-soluble plant-based microcapsules. Using plant polysaccharide modified starch pectin and carrageenan as the matrix microcapsules were prepared and their properties in vitro drug release behavior and safety were investigated. Cassava acetate starch and carrageenan were used as materials to prepare pH-dependent microcapsules. The infrared absorption, solubility, microstructure and cytotoxicity of microcapsules were investigated. The drug release behavior of microcapsules was further studied. The results showed that when pectin was not found in microcapsules, the microcapsules did not dissolve at different pH and there was no drug release. When the content of pectin in the matrix was 1% pH, the release amount of microcapsule was the largest, and the release amount of microcapsule decreased with the increase of pectin concentration. The results of cytotoxicity showed that microcapsules were safe and non-toxic. Pectin was a key component of pH dependent microcapsules. By adjusting the content of pectin, the effective release of microcapsules in pH neutral environment can be realized, and the drug release in the intestinal tract can be realized. Improve the bioavailability of drugs .4.The quality evaluation and stability of hollow capsules were studied by using hydroxypropyl starch empty capsules and gelatin hollow capsules. According to the requirements of the 2015 edition of the Chinese Pharmacopoeia, the two capsules were loaded with acid-base drugs respectively, and the capsules were loaded with high temperature and high humidity. The stability and dissolution of gelatin hollow capsules were measured under irradiation conditions. The results showed that the properties of the empty starch capsules were similar to those of the gelatin hollow capsules.
【學(xué)位授予單位】：聊城大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：TB383.2;TQ460.4

【參考文獻】

相關(guān)期刊論文 前10條

1 古麗曼·木哈買提拜;;高效液相色譜法測定生鮮乳中氨芐青霉素的殘留量[J];新疆畜牧業(yè);2015年12期

2 楊燕;周亮;舒婷;;pH敏感型藥物載體材料的研究進展[J];化學(xué)工程師;2015年10期

3 姚云真;關(guān)羽;;甘油對明膠溶液性能的影響研究[J];明膠科學(xué)與技術(shù);2015年02期

4 尚佳萃;劉潔;劉亞偉;;測定醋酸酯淀粉熱力學(xué)特性的方法研究進展[J];食品安全質(zhì)量檢測學(xué)報;2015年05期

5 劉李梅;韓麗;楊明;郭志燁;鄒文銓;;植物空心膠囊的研究進展[J];中藥與臨床;2014年05期

6 王曉芳;馮瑞;林好;龐杰;;應(yīng)用于空心膠囊氧化魔芋葡甘聚糖-馬鈴薯淀粉復(fù)合膜制備及性能測試[J];糧食與油脂;2014年04期

7 張夕瑤;王永祿;王棟;李學(xué)明;;HPMC膠囊的體內(nèi)外研究現(xiàn)狀與應(yīng)用展望[J];中國生化藥物雜志;2014年01期

8 吳國慶;;一種新型植物空心膠囊的研制[J];明膠科學(xué)與技術(shù);2013年04期

9 古碧;李開綿;張振文;謝彩鋒;李凱;;我國木薯加工產(chǎn)業(yè)發(fā)展現(xiàn)狀及發(fā)展趨勢[J];農(nóng)業(yè)工程技術(shù)(農(nóng)產(chǎn)品加工業(yè));2013年11期

10 江濤;李衛(wèi)平;雷健;路勇;劉同華;;天然多糖作為結(jié)腸定位給藥系統(tǒng)材料的研究進展[J];中國藥房;2013年23期

，

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