本文關(guān)鍵詞： 聚六亞甲基單胍 紫外輻照 抗菌水凝膠 天然植物纖維 生物相容性　出處：《浙江大學》2017年碩士論文　論文類型：學位論文

【摘要】：細菌感染已成為人類健康的主要威脅之一�？股乇粡V泛用于各種細菌感染的治療,但是抗生素的過量使用導致了耐藥細菌的產(chǎn)生,并且對環(huán)境造成污染。因此,開發(fā)高效、安全的抗菌材料,在人體外抑制細菌的生長,減少對人體的傷害,具有非常重要的現(xiàn)實意義和廣闊的應(yīng)用前景。聚六亞甲基單胍作為一種新型環(huán)保型高分子殺菌消毒劑,具有廣譜抗菌性能,且價格低廉、無毒無害。本論文采用商品化的聚六亞甲基單胍鹽酸鹽,通過化學改性法制備了具有長效抗菌性能的水凝膠和天然植物纖維,并詳細研究了它們的物理化學性能。水凝膠是一種由物理或化學作用形成的具有特定三維網(wǎng)絡(luò)結(jié)構(gòu)的材料,在組織工程支架、傷口敷料、藥物載體等生物醫(yī)學領(lǐng)域被廣泛應(yīng)用�？咕z能夠避免或減少抗生素的使用,具有臨床應(yīng)用的潛力。本論文首先合成了可聚合的聚六亞甲基單胍大分子前體,然后通過光引發(fā)的自由基聚合制備了聚六亞甲基單胍-聚丙烯酰胺水凝膠。采用抑菌圈法及光密度值法表征了水凝膠的抑菌性能。由于聚六亞甲基單胍鏈段通過共價鍵結(jié)合于水凝膠的骨架上,經(jīng)多次長時間浸泡洗滌后仍不會流失,該水凝膠對金黃色葡萄球菌和大腸桿菌具有良好的長效抗菌性能。此外,溶血實驗、細胞存活率測試表明該抗菌水凝膠具有良好的生物相容性,有望成為一種新型生物醫(yī)學材料。天然植物纖維來源豐富、價格低廉,且易于降解,是屬于符合可持續(xù)發(fā)展要求的天然可再生資源,廣泛應(yīng)用于紡織品材料領(lǐng)域。織物在環(huán)境中易產(chǎn)生細菌感染問題,與人體接觸時會對人體造成潛在危險。因此,對天然植物纖維進行化學改性,使其具有良好的抗菌性能,意義深遠。本論文選取了兩種天然植物纖維,即醋酸纖維和棉紗線,通過簡單的水相接枝改性方法,制備了聚六亞甲基單胍接枝改性的抗菌天然植物纖維。抑菌圈法、光密度值法等抗菌實驗表明其對金黃色葡萄球菌和大腸桿菌均具有良好的抗菌性能,有望成為新型紡織品材料。
[Abstract]:Bacterial infection has become one of the major threats to human health. Antibiotics are widely used in the treatment of various bacterial infections, but the excessive use of antibiotics leads to the production of drug-resistant bacteria. Therefore, the development of efficient and safe antimicrobial materials to inhibit the growth of bacteria outside the human body, reduce the harm to the human body. Poly (hexamethylene monoguanidine), as a new environmental protection macromolecule sterilizing disinfectant, has broad spectrum antibacterial properties and low price. In this paper, hydrogels and natural plant fibers with long-term antibacterial properties were prepared by chemical modification with commercial polyhexamethylene monoguanidine hydrochloride. The physical and chemical properties of hydrogels are studied in detail. Hydrogel is a kind of material with specific three-dimensional network structure formed by physical or chemical action, in tissue engineering scaffold, wound dressing. Drug carriers and other biomedical fields are widely used. Antibacterial hydrogels can avoid or reduce the use of antibiotics. In this paper, we first synthesized polymerizable polyhexamethylene monoguanidine macromolecular precursor. Then the polyhexamethylene monoguanidine polyacrylamide hydrogel was prepared by photo-initiated free radical polymerization. The bacteriostatic properties of the hydrogel were characterized by bacteriostasis method and optical density method. Due to the passage of polyhexamethylene-monoguanidine chain through the polyhexamethylene-monoguanidine chain. The covalent bond binds to the framework of the hydrogel. The hydrogel has good long-term antibacterial properties against Staphylococcus aureus and Escherichia coli. In addition, the hemolysis experiment was carried out. The cell viability test shows that the antibacterial hydrogel has good biocompatibility and is expected to be a new biomedical material. The natural plant fiber is rich in sources, low in price and easy to degrade. It is a natural renewable resource which meets the requirements of sustainable development. It is widely used in the field of textile materials. Fabric in the environment is prone to the problem of bacterial infection, and contact with human body will cause potential danger to human body. Chemical modification of natural plant fiber makes it have good antibacterial properties. In this paper, two kinds of natural plant fiber, acetate fiber and cotton yarn, are selected and modified by water grafting. The antimicrobial natural plant fiber modified by polyhexamethylene monoguanidine was prepared. The antibacterial experiments showed that it had good antibacterial properties against both Staphylococcus aureus and Escherichia coli. It is expected to become a new textile material.
【學位授予單位】：浙江大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：TB34

【參考文獻】

相關(guān)期刊論文 前1條

1 ZHAO LianJing;HUANG YiBing;GAO Song;CUI Yan;HE Dan;WANG Li;CHEN YuXin;;Comparison on effect of hydrophobicity on the antibacterial and antifungal activities of α-helical antimicrobial peptides[J];Science China(Chemistry);2013年09期

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本文編號：1479373