發(fā)布時(shí)間：2018-01-31 15:20

  本文關(guān)鍵詞： 聚六亞甲基單胍 紫外輻照 抗菌水凝膠 天然植物纖維 生物相容性　出處：《浙江大學(xué)》2017年碩士論文　論文類型：學(xué)位論文

【摘要】：細(xì)菌感染已成為人類健康的主要威脅之一�？股乇粡V泛用于各種細(xì)菌感染的治療,但是抗生素的過量使用導(dǎo)致了耐藥細(xì)菌的產(chǎn)生,并且對(duì)環(huán)境造成污染。因此,開發(fā)高效、安全的抗菌材料,在人體外抑制細(xì)菌的生長(zhǎng),減少對(duì)人體的傷害,具有非常重要的現(xiàn)實(shí)意義和廣闊的應(yīng)用前景。聚六亞甲基單胍作為一種新型環(huán)保型高分子殺菌消毒劑,具有廣譜抗菌性能,且價(jià)格低廉、無(wú)毒無(wú)害。本論文采用商品化的聚六亞甲基單胍鹽酸鹽,通過化學(xué)改性法制備了具有長(zhǎng)效抗菌性能的水凝膠和天然植物纖維,并詳細(xì)研究了它們的物理化學(xué)性能。水凝膠是一種由物理或化學(xué)作用形成的具有特定三維網(wǎng)絡(luò)結(jié)構(gòu)的材料,在組織工程支架、傷口敷料、藥物載體等生物醫(yī)學(xué)領(lǐng)域被廣泛應(yīng)用�？咕z能夠避免或減少抗生素的使用,具有臨床應(yīng)用的潛力。本論文首先合成了可聚合的聚六亞甲基單胍大分子前體,然后通過光引發(fā)的自由基聚合制備了聚六亞甲基單胍-聚丙烯酰胺水凝膠。采用抑菌圈法及光密度值法表征了水凝膠的抑菌性能。由于聚六亞甲基單胍鏈段通過共價(jià)鍵結(jié)合于水凝膠的骨架上,經(jīng)多次長(zhǎng)時(shí)間浸泡洗滌后仍不會(huì)流失,該水凝膠對(duì)金黃色葡萄球菌和大腸桿菌具有良好的長(zhǎng)效抗菌性能。此外,溶血實(shí)驗(yàn)、細(xì)胞存活率測(cè)試表明該抗菌水凝膠具有良好的生物相容性,有望成為一種新型生物醫(yī)學(xué)材料。天然植物纖維來源豐富、價(jià)格低廉,且易于降解,是屬于符合可持續(xù)發(fā)展要求的天然可再生資源,廣泛應(yīng)用于紡織品材料領(lǐng)域�？椢镌诃h(huán)境中易產(chǎn)生細(xì)菌感染問題,與人體接觸時(shí)會(huì)對(duì)人體造成潛在危險(xiǎn)。因此,對(duì)天然植物纖維進(jìn)行化學(xué)改性,使其具有良好的抗菌性能,意義深遠(yuǎn)。本論文選取了兩種天然植物纖維,即醋酸纖維和棉紗線,通過簡(jiǎn)單的水相接枝改性方法,制備了聚六亞甲基單胍接枝改性的抗菌天然植物纖維。抑菌圈法、光密度值法等抗菌實(shí)驗(yàn)表明其對(duì)金黃色葡萄球菌和大腸桿菌均具有良好的抗菌性能,有望成為新型紡織品材料。
[Abstract]:Bacterial infection has become one of the major threats to human health. Antibiotics are widely used in the treatment of various bacterial infections, but the excessive use of antibiotics leads to the production of drug-resistant bacteria. Therefore, the development of efficient and safe antimicrobial materials to inhibit the growth of bacteria outside the human body, reduce the harm to the human body. Poly (hexamethylene monoguanidine), as a new environmental protection macromolecule sterilizing disinfectant, has broad spectrum antibacterial properties and low price. In this paper, hydrogels and natural plant fibers with long-term antibacterial properties were prepared by chemical modification with commercial polyhexamethylene monoguanidine hydrochloride. The physical and chemical properties of hydrogels are studied in detail. Hydrogel is a kind of material with specific three-dimensional network structure formed by physical or chemical action, in tissue engineering scaffold, wound dressing. Drug carriers and other biomedical fields are widely used. Antibacterial hydrogels can avoid or reduce the use of antibiotics. In this paper, we first synthesized polymerizable polyhexamethylene monoguanidine macromolecular precursor. Then the polyhexamethylene monoguanidine polyacrylamide hydrogel was prepared by photo-initiated free radical polymerization. The bacteriostatic properties of the hydrogel were characterized by bacteriostasis method and optical density method. Due to the passage of polyhexamethylene-monoguanidine chain through the polyhexamethylene-monoguanidine chain. The covalent bond binds to the framework of the hydrogel. The hydrogel has good long-term antibacterial properties against Staphylococcus aureus and Escherichia coli. In addition, the hemolysis experiment was carried out. The cell viability test shows that the antibacterial hydrogel has good biocompatibility and is expected to be a new biomedical material. The natural plant fiber is rich in sources, low in price and easy to degrade. It is a natural renewable resource which meets the requirements of sustainable development. It is widely used in the field of textile materials. Fabric in the environment is prone to the problem of bacterial infection, and contact with human body will cause potential danger to human body. Chemical modification of natural plant fiber makes it have good antibacterial properties. In this paper, two kinds of natural plant fiber, acetate fiber and cotton yarn, are selected and modified by water grafting. The antimicrobial natural plant fiber modified by polyhexamethylene monoguanidine was prepared. The antibacterial experiments showed that it had good antibacterial properties against both Staphylococcus aureus and Escherichia coli. It is expected to become a new textile material.
【學(xué)位授予單位】：浙江大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：TB34

【參考文獻(xiàn)】

相關(guān)期刊論文 前1條

1 ZHAO LianJing;HUANG YiBing;GAO Song;CUI Yan;HE Dan;WANG Li;CHEN YuXin;;Comparison on effect of hydrophobicity on the antibacterial and antifungal activities of α-helical antimicrobial peptides[J];Science China(Chemistry);2013年09期

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本文編號(hào)：1479373