本文關(guān)鍵詞： 磁性納米顆粒膠體液滴 集體磁矩 磁場(chǎng) 動(dòng)力學(xué) 數(shù)字圖像處理　出處：《東南大學(xué)》2015年碩士論文　論文類(lèi)型：學(xué)位論文

【摘要】：近年來(lái),磁性納米材料以其磁學(xué)性質(zhì)廣泛應(yīng)用于生物醫(yī)學(xué)研究中,磁性納米粒子可以作為藥物載體,通過(guò)外加梯度磁場(chǎng),將藥物輸送至腫瘤部位,起到靶向治療的作用。磁性納米粒子還可以用于磁熱療,將磁性微粒輸送至病灶區(qū)域,在外加交變磁場(chǎng)的作用下,磁性微粒產(chǎn)生磁熱效應(yīng)從而殺死病變細(xì)胞。磁性納米粒子還可以用作MRI造影劑,如超順磁性的氧化鐵納米粒子具有較高的弛豫率和低廉的價(jià)格,并且有良好的耐受性、生物相容性及穩(wěn)定性。了解磁性納米粒子的磁學(xué)性質(zhì)對(duì)其應(yīng)用具有重要的意義,磁矩是磁性材料最基本的磁學(xué)參數(shù),很多磁強(qiáng)計(jì)測(cè)量原理就是先測(cè)出樣品的磁矩,再轉(zhuǎn)換為其他參數(shù)。測(cè)量磁性納米材料磁矩的磁強(qiáng)計(jì)可按照測(cè)量樣品的尺寸分為三類(lèi),在第一章中分別介紹了針對(duì)單個(gè)磁性納米顆粒磁矩測(cè)量方法：磁力顯微鏡、洛倫茲顯微術(shù)；針對(duì)微尺度磁性納米聚集體磁矩測(cè)量方法：超導(dǎo)量子干涉儀、巨磁電阻傳感器、磁光克爾效應(yīng)儀：針對(duì)大量磁性顆粒聚集體磁矩測(cè)量方法：振動(dòng)樣品磁強(qiáng)計(jì)、磁天平、電子順磁共振儀。簡(jiǎn)述了各個(gè)方法的原理及發(fā)展現(xiàn)狀。本論文主要研究的內(nèi)容和結(jié)果如下：第二章分析了磁矩的測(cè)量對(duì)于研究磁性材料磁學(xué)性質(zhì)具有重要的意義,而磁性粒子間的相互作用會(huì)影響其磁化強(qiáng)度,從而改變其磁矩大小�？紤]到磁性納米顆粒膠體中粒子間的相互作用力,我們提出了一種基于動(dòng)力學(xué)與數(shù)字圖像處理技術(shù)的測(cè)量磁性納米顆粒膠體液滴磁矩的新方法。將微量的水相磁性納米顆粒膠體(2uL)置于與其密度相同的有機(jī)液體中,磁性膠體液滴會(huì)在水張力的作用下形成圓球形并懸浮在有機(jī)液中。然后外加梯度磁場(chǎng),膠體液滴會(huì)在磁力的作用下沿著磁場(chǎng)增大的方向運(yùn)動(dòng)。對(duì)膠體液滴水平方向進(jìn)行受力分析,得到關(guān)于液滴速度、加速度、粘滯阻力以及磁力的方程式,即可以通過(guò)測(cè)量液滴的速度、加速度,得到液滴所受磁力,從而推算出液滴的磁矩。在第二章中,進(jìn)行了計(jì)算機(jī)數(shù)值模擬實(shí)驗(yàn),證明了此方法的可行性。并且對(duì)影響測(cè)量的靈敏度的因素進(jìn)行了分析,得出結(jié)論圖像采集裝置的采集速度越快,磁矩測(cè)量的靈敏度越高。第三章中介紹了實(shí)驗(yàn)裝置,使用Ansoft軟件對(duì)裝置中的“C”型電磁體的磁場(chǎng)分布進(jìn)行了模擬,并使用特斯拉計(jì)測(cè)量了外磁場(chǎng)強(qiáng)度,對(duì)測(cè)量值與距離的關(guān)系進(jìn)行四階多項(xiàng)式擬合,再對(duì)多項(xiàng)式求導(dǎo)得到磁場(chǎng)梯度與距離之間的函數(shù)關(guān)系。配置與磁性納米溶液濃度相當(dāng)?shù)挠袡C(jī)液,觀察到磁性納米粒子團(tuán)形成球形并懸浮于有機(jī)相中,外加梯度磁場(chǎng),液滴在運(yùn)動(dòng)的過(guò)程中始終保持均勻的球形。所以,我們可以將磁性納米顆粒膠體液滴看作整體進(jìn)行分析。第四章和第五章是本文的核心,第四章中測(cè)量了不同尺寸的磁性納米顆粒膠體液滴的磁矩大小,證明了當(dāng)磁場(chǎng)方向與液滴運(yùn)動(dòng)方向相同時(shí),磁性粒子間的磁偶和作用會(huì)增強(qiáng)其磁化強(qiáng)度。實(shí)驗(yàn)中,分別測(cè)量了不同尺寸的γ-Fe2O3與DMSA@Fe2O3磁性納米膠體液滴的磁矩,兩種材料均是由水動(dòng)力尺寸為82nm y-Fe2O3磁性納米顆粒膠體制備而成。結(jié)果得出水動(dòng)力尺寸為598nm的γ-Fe2O3磁性納米膠體液滴總磁矩大于水動(dòng)力尺寸為83nm的DMSA@Fe203。并且磁熱效應(yīng)強(qiáng)度也與水動(dòng)力尺寸成正相關(guān)。另外,從不同尺寸的Fe3O4磁性納米膠體液滴磁矩的測(cè)量結(jié)果中可以看出,水動(dòng)力尺寸接近的磁性納米顆粒膠體液滴磁矩大小接近。水動(dòng)力尺寸較大的液滴在磁場(chǎng)作用下,運(yùn)動(dòng)的過(guò)程中會(huì)出現(xiàn)明顯的團(tuán)聚現(xiàn)象,整個(gè)液滴呈固液分離的狀態(tài)。磁矩明顯大于水動(dòng)力尺寸較小的磁性顆粒液滴。通過(guò)測(cè)量數(shù)據(jù)驗(yàn)證了本方法能夠定量測(cè)量不同水動(dòng)力尺寸的磁性納米顆粒膠體液滴的磁矩。在第五章中,我們?nèi)舛确謩e為6mg/ml, 3mg/ml,1.5mg/ml, 0.75mg/ml的DMSA@Fe2O3磁性納米膠體,也使用本文提出的新方法測(cè)量了這四種濃度膠體液滴的磁矩,同時(shí)使用振動(dòng)樣品磁強(qiáng)計(jì)與磁天平對(duì)材料的飽和磁化強(qiáng)度與磁化率進(jìn)行了測(cè)量。并且測(cè)量了這四種材料在5分鐘內(nèi)的磁熱升溫值,分別計(jì)算了磁熱效應(yīng)與本方法所測(cè)磁矩、振動(dòng)樣品磁強(qiáng)計(jì)所測(cè)飽和磁化強(qiáng)度以及磁天平所測(cè)磁化率之間的線性相關(guān)系數(shù),線性相關(guān)性分別為0.986、0.844、0.945。說(shuō)明本方法所測(cè)磁矩可以定量的反映材料的磁熱效應(yīng)。
[Abstract]:In recent years, magnetic nano materials are widely used in biomedical research to the magnetic properties of magnetic nanoparticles can be used as a drug carrier, by applying a gradient magnetic field, the drug delivery to the tumor site, to targeted therapy. Magnetic nanoparticles can also be used for magnetic hyperthermia, magnetic particles transported to the lesion area under alternating magnetic field under the action of magnetic particles of magnetic heat effect to kill the cells. The magnetic nanoparticles can be used as MRI contrast agents, such as superparamagnetic iron oxide magnetic nanoparticles with high relaxation rate and low price, and has good tolerance, biocompatibility and stability. To understand the magnetic properties of magnetic nanoparticles is important the significance of the application of magnetic parameters of magnetic materials, the magnetic moment is the most basic principle is to measure a lot of magnetometer to measure the magnetic moment of the sample, then convert For the other parameters. The measurement of magnetic moment of magnetic nano materials can be measured in accordance with the size of the sample magnetometer is divided into three categories, the first chapter introduces the single magnetic nanoparticle magnetic moment measurement methods: magnetic force microscopy, Lorenz microscopy; micro nano magnetic polymer for collective magnetic moment measurement methods: Superconducting quantum interferometer, GMR sensor, the magneto-optical Kerr effect instrument: for a large number of magnetic particle aggregates magnetic moment measurement methods: vibrating sample magnetometer, magnetic balance, electron paramagnetic resonance instrument. The principle and the development of various methods. The main research content and results of this thesis are as follows: the second chapter analyzes the magnetic moment measurement has important significance for magnetic properties study of magnetic materials and magnetic interactions between particles will affect the magnetization, thereby changing the size of the magnetic moment. Considering the magnetic nanoparticles The interaction between particles in colloidal particles, we propose a new method of dynamics and the technology of digital image processing measurement of magnetic nanoparticle colloid droplets based on the micro magnetic moment. The magnetic nanoparticle colloid aqueous phase (2uL) in the same organic liquid and the density of magnetic colloidal droplets in the water tension. The formation of spherical and suspended in the organic solution. Then the gradient magnetic field, colloid droplets under the action of magnetic force, the magnetic field is increased along the direction of motion. The force analysis of droplet horizontal colloidal liquid, a liquid droplet velocity, acceleration, viscous resistance and magnetic equations, which can be measured by the droplet the velocity, acceleration, droplet by magnetic force, which calculate the magnetic moment of droplets. In the second chapter, the computer numerical simulation experiment, proved the feasibility of the method and the shadow. Factors affecting the sensitivity of the measurement are analyzed, concluded that the image acquisition device acquisition faster, the higher the sensitivity of magnetic moment measurement. The third chapter introduces the experimental device, the use of Ansoft software to the device in the "C" type electromagnet field distribution was simulated, and the use of teslameter measured magnetic field strength and the measurements are four order polynomial fitting and distance relationship, then obtain the functional relationship between the magnetic field gradient and the distance of polynomial derivation. Organic concentration distribution and magnetic nano solution the observed magnetic nano particles to form spherical and suspended in the organic phase, the gradient magnetic field, the droplet in the process of movement always keep uniform spherical. So, we can combine magnetic nanoparticle colloid droplets as a whole is analyzed. The fourth chapter and the fifth chapter is the core of this paper, the fourth chapter measurement The different sizes of the magnetic nanoparticle colloid droplet size of magnetic moment, prove that when the magnetic field direction and droplet motion in the same direction, and the magnetic dipole effect between magnetic particles will enhance the magnetization. In the experiment, different sizes of -Fe2O3 and DMSA@Fe2O3 gamma nano magnetic moment M colloidal droplet were measured. Two all of the materials by the hydrodynamic size of 82nm y-Fe2O3 magnetic nanoparticles was prepared. The hydrodynamic size of 598nm gamma -Fe2O3 magnetic nano colloidal droplets is greater than the total magnetic moment of the hydrodynamic size of 83nm DMSA@Fe203. and magnetocaloric effect strength and hydrodynamic size are positively correlated. In addition, from the results of measurement the magnetic moment of Fe3O4 magnetic nano colloidal droplets of different sizes can be seen in the magnetic nanoparticle colloid droplet size close to the hydrodynamic size close to the magnetic moment. The hydrodynamic size of large droplets in the magnetic field. Next, there was an obvious agglomeration movement in the process of the droplet is solid-liquid separation. The magnetic moment is significantly greater than the hydrodynamic size smaller droplets. The magnetic measurement data shows the method can measure magnetic moment in different hydrodynamic size of magnetic nanoparticles colloid fluid droplets. In the fifth chapter. We take the concentration were 6mg/ml, 3mg/ml, 1.5mg/ml, DMSA@Fe2O3 magnetic nano colloidal 0.75mg/ml, also use the new method proposed in this paper the four concentration of the colloidal droplets were measured simultaneously using magnetic moment, vibrating sample magnetometer and magnetic balance on the saturation magnetization and magnetic susceptibility measurements were carried out. The four kinds of materials in magnetic heat 5 minutes heating value was measured and calculated the magnetocaloric effect and the method of measuring magnetic moment, vibrating sample magnetometer measuring saturation magnetization and magnetic susceptibility of balance measurement Linear correlation coefficient and linear correlation of 0.986,0.844,0.945. show that the magnetic moment measured by this method can quantitatively reflect the magnetocaloric effect of the material.

【學(xué)位授予單位】：東南大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2015
【分類(lèi)號(hào)】：TB383.1;R318.08

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1 江強(qiáng);周細(xì)應(yīng);;磁性納米材料的制備及其在軍事上的應(yīng)用[J];材料科學(xué)與工程學(xué)報(bào);2012年03期

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本文編號(hào)：1469514