本文關(guān)鍵詞：納米水分散體系的瞬時納米制備研究及技術(shù)應(yīng)用　出處：《揚州大學(xué)》2017年碩士論文　論文類型：學(xué)位論文

  更多相關(guān)文章： 瞬時納米制備技術(shù) 瞬時納米乳化法 納米水乳液 瞬時納米析出法 聚集誘導(dǎo)發(fā)光效應(yīng) 膠體穩(wěn)定性

【摘要】：納米懸浮液和納米乳液均屬于典型的膠體材料。由于擁有納米級別的尺寸,展現(xiàn)出獨特的物理和化學(xué)性質(zhì),如粘度低、擴散滲透性強、比表面積大、生物利用率高等優(yōu)點,在醫(yī)學(xué)示蹤、制藥、食品、化妝品、農(nóng)藥、石化、機械加工等領(lǐng)域具有廣泛的應(yīng)用。本論文嘗試提出膠體材料制備新概念,發(fā)展膠體材料制備新方法,拓展該技術(shù)在各領(lǐng)域內(nèi)的應(yīng)用,并為建立完備技術(shù)奠定理論基礎(chǔ)和框架。具體工作為:1)以近年出現(xiàn)的瞬時納米析出法(FNP)為基礎(chǔ),制備了具有聚集誘導(dǎo)發(fā)光(AIE)效應(yīng)的納米顆粒;2)從藥物示蹤的實際應(yīng)用出發(fā),首次研究了顆粒粒徑、藥物分子共軛基團、高分子玻璃化轉(zhuǎn)變溫度及油狀添加物對熒光發(fā)光強度的影響;3)首次提出瞬時納米乳化(FNE)的方法,并提出瞬時納米制備(FNF)技術(shù)的新概念,探究了乳液形成的機理,優(yōu)化了材料制備的配方,技術(shù)上實現(xiàn)了 FNE的簡易操作;5)將FNE技術(shù)應(yīng)用到基礎(chǔ)油乳液的制備,探究控制所形成乳液尺寸的因素,對應(yīng)用中油類的預(yù)測選擇及乳液制備方案的事先確定具有重要的科學(xué)指導(dǎo)意義。第二章使用疏水性強的四苯基乙烯(TPE,ACDLogP = 8.41)作為目標分子,兩親性嵌段共聚物mPEG(5k)-b-PLGA(10k)作為穩(wěn)定劑,通過瞬時納米析出法得到了粒徑在100 nm左右的具有優(yōu)秀AIE效應(yīng)的熒光納米顆粒,首次討論了熒光強度隨粒徑增大而減小的規(guī)律。并以藥物示蹤為應(yīng)用模板研究了乳液、藥物和高分子輔料對共混后熒光納米顆粒的影響,研究了共軛結(jié)構(gòu)、高玻璃化轉(zhuǎn)變溫度和油狀化合物對聚集誘導(dǎo)發(fā)光強度的猝滅效應(yīng)。該工作在制備AIE納米制劑時對小分子藥物、高分子輔料、及油類的選取具有重要的指導(dǎo)意義。第三章提出并發(fā)展了 FNE技術(shù)。通過使用疏水性高的紅桔精油(ACDLogP = 4.37)作為模型油,分別使用吐溫80和mPEG-b-PLGA作為表面活性劑,成功制備出最低液滴直徑16 nm的納米乳液。并對配方進行優(yōu)化,證實了高分子乳化劑比吐溫80用量更少,粒徑更小。通過改變混合雷諾數(shù)獲得雷諾數(shù)與粒徑及時間穩(wěn)定性的關(guān)系,確定了 FNE所需充分混合的最低雷諾數(shù)為2200。將含鹽與無鹽體系乳液zeta電位和粒徑進行對比證實了穩(wěn)定機理為乳化劑位阻作用。另外,通過比較粒徑穩(wěn)定性證實了 FNE法比傳統(tǒng)滴加攪拌法更具有小粒徑、窄分布和高穩(wěn)定性的優(yōu)勢。該技術(shù)為滿足化工、農(nóng)業(yè)、醫(yī)療等廣泛領(lǐng)域?qū){米乳液大量需求開辟了新道路。第四章將FNE的應(yīng)用領(lǐng)域拓展到基礎(chǔ)油。使用了吐溫80、mPEG-b-PLGA、APG(8-10和8-14)為表面活性劑,對礦物油和煤油乳液的配方進行優(yōu)化,得到了粒徑約100 nm的礦物油納米乳液和粒徑約35 nm的煤油納米乳液。并以含硅表面活性劑和二氧化硅小球(10 nm)為表面活性劑,探索制備了硅油乳液。通過對油水界面張力的測量,計算了毛細管數(shù),獲得油相和表面活性劑選擇對乳液初始液滴大小的影響。并評價了煤油水乳液對金屬表面油污的清洗性能和礦物油水乳液對金屬表面的潤滑性能。該工作拓展了 FNE的使用范圍,對FNE使用中油相的預(yù)選和配方的設(shè)計提供了重要的理論指導(dǎo)。
[Abstract]:Nano suspension and nano emulsion colloid materials belong to typical. With nano scale size, exhibit unique physical and chemical properties, such as low viscosity, diffusion and permeability, large surface area, high bioavailability and advantages in medical, pharmaceutical, food, tracer, cosmetics, pesticides, petrochemicals. With the extensive application of mechanical processing and other fields. This paper tries to put forward the new concept for preparing colloidal materials, development of colloid materials preparation methods, application of the technology in various fields, and laid the theoretical foundation and framework for the establishment of complete technology. The main work includes: 1) the instantaneous nano precipitation method appeared in recent years (FNP) as the foundation, was prepared with aggregation induced emission (AIE) nanoparticles effect; 2) starting from the actual application of drug tracing was studied for the first time, particle size, molecular conjugated polymer, glass transition temperature and oil Tim With the influence on the luminescence intensity of fluorescence; 3) first proposed instantaneous nano emulsion (FNE) method, and put forward the instantaneous nano preparation (FNF) new concept and technology, to explore the mechanism of emulsion formation, optimize the material preparation formula, the technology to realize the simple operation of FNE; 5) FNE technology is applied to the base oil emulsion preparation, control of formation factors of emulsion size, scheme selection and prediction of oil emulsion preparation using the previously determined has important scientific significance. The second chapter uses four phenyl ethylene hydrophobic (TPE, ACDLogP = 8.41) as the target molecule, two Pro block copolymer mPEG (5K) -b-PLGA (10K) as the stabilizer, the instantaneous nano precipitation method has been size of about 100 nm and has a good effect of AIE particle fluorescent nanoparticles was discussed for the first time, the fluorescence intensity increases with the particle size decreases by medicine and law. Study on the application of tracer emulsion as template. The effect of drugs and excipients on polymer blend nanoparticles, study the conjugate structure, high glass transition temperature and oil quenching effect of compound aggregation induced emission intensity. The work in the preparation of AIE nano preparation of small molecule drugs, polymer materials, has an important guide selection and oil. In the third chapter, proposed and developed by FNE technology. The high hydrophobicity of tangerine essential oils (ACDLogP = 4.37) were used as model oil, Twain 80 and mPEG-b-PLGA as a surfactant to produce nanometer emulsion minimum droplet diameter of 16 nm. And the optimized formulation. Confirmed that the polymer emulsifier amount less than the Twain 80, a smaller size. By changing the mixed relationship between Reynolds number and the Reynolds number of particle size and time stability, determine the FNE required to fully mix the most Low Reynolds number of 2200. will be salt and salt free emulsion system of zeta potential and particle size were compared and confirmed the stable mechanism of emulsifier steric effect. In addition, by comparing the particle size stability confirmed the FNE dropping more than traditional mixing method has small particle size, narrow size distribution and high stability advantages. This technology to meet the chemical industry agriculture, medical and other fields, has opened up a new way for nano emulsion. The fourth chapter will demand the application of FNE to expand the base oil. The use of the Twain 80, mPEG-b-PLGA, APG (8-10 and 8-14) as the surfactant, the mineral oil and kerosene emulsion formulation was optimized, by kerosene nano emulsion mineral oil emulsion and nano particle size of about 100 nm diameter of about 35 nm. And the surfactant containing silicon and silica particles (10 nm) as the surfactant, explore the silicone oil emulsion was prepared. Through the measurement of interfacial tension, calculation The capillary number, obtain oil and surfactant of emulsion initial droplet size. And evaluate the cleaning performance and mineral oil-water emulsion on the metal surface greasy dirt water kerosene emulsion on lubrication performance of the metal surface. This work extends the use of FNE, provides an important theoretical guidance for the design of pre FNE and with oil formula.

【學(xué)位授予單位】：揚州大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：TB383.1

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本文編號：1379972