發(fā)布時(shí)間：2018-01-04 13:09

  本文關(guān)鍵詞：基于離子液體溶劑的殼聚糖膜的制備與力學(xué)性能研究　出處：《青島科技大學(xué)》2015年碩士論文　論文類(lèi)型：學(xué)位論文

  更多相關(guān)文章： 殼聚糖膜 力學(xué)性能 離子液體

【摘要】：殼聚糖具有良好的成膜性、抑菌性,在醫(yī)藥領(lǐng)域應(yīng)用廣泛,因此對(duì)殼聚糖膜的制備研究受到了廣大學(xué)者關(guān)注。鑒于離子液體的結(jié)構(gòu)可設(shè)計(jì)性、難揮發(fā)、熱穩(wěn)定性好、溶解能力強(qiáng)等優(yōu)點(diǎn),本文將其水溶液作為溶解殼聚糖及丁基殼聚糖的優(yōu)良溶劑,制備殼聚糖及丁基殼聚糖膜,并與常規(guī)體系的制膜工藝進(jìn)行對(duì)比研究。研究發(fā)現(xiàn),離子液體體系下制備的殼聚糖膜及丁基殼聚糖膜的力學(xué)性能、熱穩(wěn)定性均較常規(guī)體系有所改善,而且丁基殼聚糖膜更易被降解吸收,為殼聚糖及其衍生物在生物醫(yī)用領(lǐng)域的應(yīng)用奠定了理論基礎(chǔ)。本文設(shè)計(jì)并合成了一系列氨基酸類(lèi)及咪唑類(lèi)離子液體,考察了殼聚糖及丁基殼聚糖在上述水溶液中的溶解度,篩選出1-羧甲基-N-甲基咪唑氯鹽([Acmim]Cl)、甘氨酸鹽酸鹽([Gly]C1)分別用于溶解殼聚糖、丁基殼聚糖,并對(duì)再生的殼聚糖、丁基殼聚糖及原料進(jìn)行分子量測(cè)定和表征。結(jié)果發(fā)現(xiàn),在溶解過(guò)程中,殼聚糖與丁基殼聚糖發(fā)生不同程度的降解,但其主體結(jié)構(gòu)保持不變,沒(méi)有與離子液體發(fā)生反應(yīng)。在HAc常規(guī)體系和[Acmim]Cl離子液體體系下制備殼聚糖膜,并進(jìn)行單因素實(shí)驗(yàn)得到的最佳工藝條件。實(shí)驗(yàn)測(cè)得,HAc體系殼聚糖膜的斷裂強(qiáng)度為176.58MPa,伸長(zhǎng)率為4.06%,初始模量為2.09 GPa; [Acmim]Cl離子液體體系殼聚糖膜的斷裂強(qiáng)度為190.02 MPa,伸長(zhǎng)率為3.93%,初始模量為3.53 GPa。結(jié)果表明,離子液體體系殼聚糖膜力學(xué)性能優(yōu)于HAc體系殼聚糖膜,膜表面較光滑,熱穩(wěn)定性較好,溶脹度較小,孔隙率較小,降解率較低。在HAc常規(guī)體系和[Gly]Cl離子液體體系下制備丁基殼聚糖膜,并進(jìn)行單因素實(shí)驗(yàn)得到的最佳工藝條件。實(shí)驗(yàn)測(cè)得,HAc體系丁基殼聚糖膜的斷裂強(qiáng)度為152.24 MPa,伸長(zhǎng)率為3.17%,初始模量為2.93 GPa；離子液體體系丁基殼聚糖膜的斷裂強(qiáng)度為168.871MPa,伸長(zhǎng)率為3.72%,初始模量為2.41 GPa。結(jié)果表明,離子液體體系丁基殼聚糖膜力學(xué)性能優(yōu)于HAc體系丁基殼聚糖膜,膜表面較光滑,熱穩(wěn)定性較好,溶脹度較小,孔隙率較小,降解率較低。同時(shí),丁基殼聚糖膜的力學(xué)性能略低于殼聚糖膜,易熱分解,但其溶脹度、孔隙率以及降解率均高于殼聚糖膜。
[Abstract]:Chitosan has good film-forming and bacteriostatic properties, and has been widely used in the field of medicine. Therefore, the preparation of chitosan membrane has attracted the attention of many scholars. In view of the structure design of ionic liquids, it is difficult to volatilize. In this paper, the aqueous solution of chitosan and Ding Ji chitosan was used as an excellent solvent to prepare chitosan and Ding Ji chitosan membrane. The results show that the mechanical properties and thermal stability of chitosan film and Ding Ji chitosan membrane prepared in ionic liquid system are better than those in conventional system. Ding Ji chitosan film is more easily degraded and absorbed, which lays a theoretical foundation for the application of chitosan and its derivatives in the field of biomedical. In this paper, a series of amino acids and imidazole ionic liquids were designed and synthesized. The solubility of chitosan and Ding Ji chitosan in the above aqueous solution was investigated, and 1-carboxymethyl -N-methyl imidazole chloride salt was screened out. [Acmim, glycine hydrochloride. [Gly] C _ 1) was used to dissolve chitosan and Ding Ji chitosan respectively, and the molecular weight of regenerated chitosan, Ding Ji chitosan and raw materials were determined and characterized. Chitosan and Ding Ji were degraded to varying degrees, but their main structure remained unchanged and did not react with ionic liquids. [Chitosan membrane was prepared in Acmim] Cl ionic liquid system, and the optimum technological conditions were obtained by single factor experiment. The fracture strength of chitosan membrane in HAC system was 176.58 MPA. The elongation is 4.06 and the initial modulus is 2.09 GPa. [The breaking strength, elongation and initial modulus of chitosan membrane of Acmim] Cl ionic liquid system were 190.02 MPA, 3.93 and 3.53 GPA, respectively. The mechanical properties of chitosan membrane in ionic liquid system are better than those in HAc system. The surface of the membrane is smooth, the thermal stability is better, the swelling degree is smaller, the porosity is smaller, the degradation rate is lower. [Ding Ji chitosan membrane was prepared in Gly] Cl ionic liquid system, and the optimum technological conditions were obtained by single factor experiment. The breaking strength, elongation and initial modulus of Ding Ji chitosan membrane in HAc system were 152.24 MPA, 3.17 and 2.93 GPA, respectively. The breaking strength, elongation and initial modulus of Ding Ji chitosan membrane were 168.871 MPa, 3.72 and 2.41 GPa. The mechanical properties of Ding Ji chitosan membrane in ionic liquid system were better than those in HAc system, such as smooth surface, good thermal stability, low swelling degree, low porosity and low degradation rate. The mechanical properties of Ding Ji chitosan film were slightly lower than those of chitosan film and could be decomposed easily, but the swelling degree, porosity and degradation rate of Ding Ji chitosan film were higher than that of chitosan film.
【學(xué)位授予單位】：青島科技大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2015
【分類(lèi)號(hào)】：O636.1;TB383.2

【參考文獻(xiàn)】

相關(guān)碩士學(xué)位論文 前1條

1 魏靜;甲殼素晶須/聚乳酸納米纖維膜的制備及其應(yīng)用研究[D];江南大學(xué);2012年

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本文編號(hào)：1378627