【摘要】：目的 :探討血清生長(zhǎng)分化因子-15(GDF-15)與N末端B型利鈉肽原(NT-pro BNP)聯(lián)合檢測(cè)在心肺復(fù)蘇(CPR)成功后患者近期預(yù)后評(píng)估中的應(yīng)用價(jià)值。方法:選取我院心臟驟停CPR成功的患者共102例,分別檢測(cè)其CPR后即刻、12 h、24~48 h的血清GDF-15水平,并根據(jù)血清GDF-15水平升高時(shí)間分為3組,A組(31例):CPR后即刻、12 h和24~48 h血清GDF-15水平一直1200 ng/L;B組(35例):CPR后12 h和24~48 h血清GDF-15水平持續(xù)升高,且一直1200 ng/L;C組(36例):CPR后12 h和24~48 h血清GDF-15水平持續(xù)升高,但24~48 h較12 h時(shí)降低。同時(shí)檢測(cè)3組患者各時(shí)間點(diǎn)血清NT-pro BNP水平及左心室射血分?jǐn)?shù)(LVEF)。隨訪3組患者CPR后6個(gè)月的死亡情況。結(jié)果:血清GDF-15和NT-pro BNP具有交互作用(P0.05),即NT-pro BNP表達(dá)水平隨著血清GDF-15水平變化而變化;血清GDF-15與LVEF呈負(fù)相關(guān)(r=-0.530,P0.001)。血清GDF-15水平高表達(dá)者(1800 ng/L)、血清NTpro BNP水平高表達(dá)者(400 pg/ml)死亡率均高于血清GDF-15、NT-pro BNP水平低表達(dá)者(P0.05);生存分析結(jié)果顯示,B組患者6個(gè)月生存率低于A組及C組(P0.05);A組和C組比較,差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論:血清GDF-15與NT-pro BNP聯(lián)合檢測(cè)能較好地預(yù)測(cè)CPR患者的近期臨床預(yù)后。
[Abstract]:Aim: to investigate the value of combined detection of serum growth differentiation factor-15 (GDF-15) and N-terminal B-type natriuretic peptide (NT-pro BNP) in evaluating the short-term prognosis of patients after successful cardiopulmonary resuscitation (CPR). Methods: a total of 102 CPR patients with cardiac arrest in our hospital were selected. Serum GDF-15 levels were measured immediately, 12 h, and 24 h after CPR, and were divided into 3 groups according to the time when the serum GDF-15 level increased. Group A (31 cases immediately after): CPR) was divided into 3 groups: group A (n = 31), and group A (n = 31). 12 h and 24 h 48 h serum GDF-15 levels remain at 1200 ng/L; The level of serum GDF-15 in group B (n = 35) was higher than that in group B (n = 35) at 12 h and 24 h after): CPR, and the serum GDF-15 level in group B (n = 36) was higher than that in group B (n = 36) at 12 h and 24 h after): CPR (n = 36), but decreased at 24 h (P < 0. 05). At the same time, the levels of serum NT-pro BNP and left ventricular ejection fraction (LVEF).) were measured at different time points in three groups. All patients were followed up for 6 months after CPR. Results: there was interaction between serum GDF-15 and NT-pro BNP (P0.05), that is, the expression level of NT-pro BNP changed with the change of serum GDF-15 level, and there was a negative correlation between serum GDF-15 and LVEF (r = 0.530, P0.001). The mortality of patients with high expression of serum GDF-15 (1800 ng/L) and high expression of serum NTpro BNP (400 pg/ml) was higher than that of those with low expression of serum GDF-15,NT-pro BNP (P0.05). The results of survival analysis showed that the 6-month survival rate of group B was lower than that of group A and C (P0.05); A group and C group, there was no significant difference (P0.05). Conclusion: the combined detection of serum GDF-15 and NT-pro BNP can predict the short-term clinical prognosis of CPR patients.
【作者單位】： 承德市中心醫(yī)院急診科;
【基金】：承德市科學(xué)技術(shù)研究與發(fā)展計(jì)劃項(xiàng)目(20142009)
【分類號(hào)】：R459.7

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