睡眠腦電自動分期方法研究
[Abstract]:The study of sleep staging has some clinical and practical significance. Sleep staging plays an important role in the evaluation of sleep quality and the adjuvant treatment of sleep related diseases. Traditional artificial sleep staging has its limitations: low efficiency, time consuming and labor consumption, so it is of great significance to study automatic sleep staging. EEG is the most important physiological signal to analyze sleep. By processing the sleep EEG, the characteristic parameters of different sleep periods can be extracted, and the sleep stages are carried out with the help of classifier. Sleep EEG is a kind of complex, time-varying nonlinear non-stationary signal. In this paper, the feature of sleep is extracted by combining the nonlinear dynamic method, sample entropy and time-frequency analysis method, Hilbert-Huang transform. By calculating the marginal spectrum of each sleep segment and calculating the energy ratio of each EEG rhythm, and combining with the entropy characteristics of the sleep EEG sample, all these sleep characteristics are used as the input of the classifier. And with the help of Libsvm classification toolbox developed by Dr. Lin Zhiren, University of Taiwan to stage sleep. The experimental data were obtained from the Sleep-EDF database in PhysioBank of MIT-BIT. Ten subjects were selected to study sleep stages with two conductance EEG signals. In this paper, sleep is divided into arousal, NREM 2 and NREM3 (deep sleep), NREM 1/REM). The experimental results show that the sleep characteristics of sleep EEG can be obtained effectively by sample entropy and Hilbert-Huang transform. There was a certain regularity between the entropy values of samples in different sleep periods. In the non-rapid eye movement period, the sample entropy value decreased with the deepening of sleep, and reached the minimum value in the NREM 3 / 4 phase. The marginal spectrum of EEG obtained by Hilbert-Huang transform is different in different sleep periods, and the energy ratio of EEG rhythm can well characterize different sleep periods. But the effect of only using sample entropy to stage sleep is general, but only using Hilbert-Huang transform to extract sleep features, the effect of sleep staging is better. By combining sample entropy and Hilbert-Huang transform to extract sleep features, the effect of sleep staging is further improved, which is better than that of only one of the methods, and the overall accuracy of stage is 89.9. It can be seen that the method of sample entropy and Hilbert-Huang transform is an ideal method for sleep staging, and the feasibility of using EEG for sleep staging is also confirmed.
【學(xué)位授予單位】:廣東工業(yè)大學(xué)
【學(xué)位級別】:碩士
【學(xué)位授予年份】:2015
【分類號】:R740;TN911.7
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