發(fā)布時間：2018-11-19 19:32

【摘要】：目的：探討高通量血液透析(HFHD)和血液透析濾過(OL-HDF)兩種血液凈化模式對尿毒癥患者血清白介素-1β(IL-1β)、超敏C-反應蛋白(hs-CRP)、降鈣素原(PCT)、鈣(Ca)、磷(P)、胎球蛋白A(Fetuin-A)水平的影響,旨在探討求其相關性。方法：按不同血液凈化模式,將維持性血液透析(MHD)患者隨機分為A組HFHD組30例,B組OL-HDF組30例,C組健康對照組16例,測定A組、B組透析前、透析6個月后血清IL-1β、hs-CRP、PCT、Ca、P、Fetuin-A值,測定C組晨起空腹血清IL-1β、hs-CRP、PCT、Ca、P、Fetuin-A值。結(jié)果：A、B組透析前血清IL-1β、hs-CRP、PCT、P指標均較C組明顯升高(P0.05),Ca、Fetuin-A指標較C組明顯降低(P0.05)。治療六個月后,A、B組血清IL-1β、hs-CRP、P指標均明顯降低,B組降低幅度大于A組(P0.05),A、B組血清Fetuin-A值明顯升高,B組升高幅度大于A組(P0.05)。血清Fetuin-A與IL-1β、hs-CRP、P、Ca×P呈負相關關系。結(jié)論：維持性血液透析(MHD)患者存在微炎癥狀態(tài),其鈣化抑制因子Fetuin-A較正常人明顯降低,本研究證明,血清Fetuin-A與IL-1β、hs-CRP、P、CaXP呈負相關關系,長期OL-HDF治療(治療大于6個月),對于改善MHD患者微炎癥狀態(tài)及升高鈣化抑制因子Fetuin-A效果均明顯優(yōu)于HFHD。
[Abstract]:Objective: to investigate the effects of high-throughput hemodialysis (HFHD) and hemodiafiltration (OL-HDF) on serum interleukin-1 尾 (IL-1 尾), hypersensitive C-reactive protein (hs-CRP) and procalcitonin (PCT), in uremic patients. The effect of calcium, (Ca), phosphorus, (P), fetal globin A (Fetuin-A) level was studied. Methods: according to different blood purification models, the patients with maintenance hemodialysis (MHD) were randomly divided into A group (30 cases), B group (30 cases) and C group (16 cases). After 6 months of dialysis, the serum IL-1 尾 and hs-CRP,PCT,Ca,P,Fetuin-A levels were measured. The fasting serum IL-1 尾 and hs-CRP,PCT,Ca,P,Fetuin-A levels in group C were measured from morning to morning. Results: before dialysis, serum IL-1 尾 and hs-CRP,PCT,P in group A were significantly higher than those in group C (P0.05), and Ca,Fetuin-A were significantly lower than those in group C (P0.05). After six months of treatment, the serum IL-1 尾 and hs-CRP,P levels in group A were significantly lower than those in group A (P0.05). The serum Fetuin-A level in group A was significantly higher than that in group B (P0.05), and the increase in serum Fetuin-A in group B was higher than that in group A (P0.05). Serum Fetuin-A was negatively correlated with IL-1 尾 and hs-CRP,P,Ca 脳 P. Conclusion: there is a microinflammatory state in (MHD) patients with maintenance hemodialysis, and the calcification inhibitory factor (Fetuin-A) is significantly lower than that in normal controls. This study proves that serum Fetuin-A is negatively correlated with IL-1 尾 and hs-CRP,P,CaXP. Long-term OL-HDF therapy (more than 6 months) was more effective than HFHD. in improving microinflammation and increasing calcification inhibitory factor (Fetuin-A) in patients with MHD.
【學位授予單位】：山東大學
【學位級別】：碩士
【學位授予年份】：2015
【分類號】：R692.5

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