體檢人群尿微量白蛋白肌酐比的臨床意義
發(fā)布時(shí)間：2018-11-18 15:32
【摘要】：目的探討尿微量白蛋白肌酐比(mALB/Cr)在體檢人群中的分布特征及其與相關(guān)代謝指標(biāo)的關(guān)系。方法收集2013年11月至2014年10月我院體檢中心體檢項(xiàng)目包括尿mALB/Cr的4 184例體檢者的體質(zhì)量指數(shù)(BMI)、收縮壓(SBP)、舒張壓(DBP)、腰圍、臀圍、腰臀比(WHR)、尿mALB/Cr及血糖(GLU)、血脂〔總膽固醇(TC)、甘油三酯(TG)、高密度脂蛋白膽固醇(HDL-C)、低密度脂蛋白膽固醇(LDL-C)〕、腎功能〔尿素氮(BUN)、血肌酐(SCr)、尿酸(UA)、血清胱抑素C(Cys-C)、估計(jì)腎小球?yàn)V過率(eGFR)〕、同型半胱氨酸(Hcy)等結(jié)果,分析尿mALB/Cr在體檢人群中的分布特征,尿mALB/Cr與相關(guān)代謝指標(biāo)的關(guān)系,微量白蛋白尿(MAU)發(fā)生的獨(dú)立危險(xiǎn)因素。結(jié)果 14 184例納入分析的體檢者的尿mALB/Cr中位數(shù)(四分位間距)為5.7(3.1~11.8)mg/g,其中男性5.4(3.0~11.3)mg/g,女性6.3(3.6~13.2)mg/g,男女性別間差異有統(tǒng)計(jì)學(xué)意義(P0.05)。2體檢者尿mALB/Cr總陽性率(mALB/Cr≥30mg/g為陽性)為10.95%,其中男性10.96%,女性10.90%,男女性別間差異無統(tǒng)計(jì)學(xué)意義(P0.05)。3尿mALB/Cr中位數(shù)與陽性率均隨著年齡增加而升高。4按mALB/Cr30mg/g、30~300mg/g、300mg/g分為正常、微量白蛋白尿、顯性白蛋白尿3組,3組體檢者間的年齡、BMI、SBP、DBP、腰圍、WHR、GLU、HDL-C、TG、SCr、BUN、UA、eGFR、Cys-CR的差異均有統(tǒng)計(jì)學(xué)意義(P0.05)。5Logistic多元回歸分析顯示年齡、SBP、WHR、GLU、TG的增加及eGFR的降低是微量白蛋白尿發(fā)生的獨(dú)立危險(xiǎn)因素。結(jié)論體檢人群中尿mALB/Cr異常率較高,年齡、血壓、血糖、血脂升高及腎功能下降均可增加微量白蛋白尿發(fā)生的風(fēng)險(xiǎn),應(yīng)加強(qiáng)對(duì)高代謝綜合征及中老年人群的尿mALB/Cr檢測(cè)。
[Abstract]:Objective to investigate the distribution of urinary albumin creatinine ratio (mALB/Cr) and its relationship with related metabolic indexes. Methods from November 2013 to October 2014, the body mass index (BMI), (SBP), diastolic blood pressure (DBP), waist circumference, hip circumference and waist-to-hip ratio (WHR),) of 4,184 subjects with urinary mALB/Cr were collected. Urine mALB/Cr and blood glucose (GLU), lipids (total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C) low density lipoprotein cholesterol (LDL-C),) renal function (urea nitrogen (BUN),) The serum levels of cystatin C (Cys-C) and glomerular filtration rate (eGFR),) homocysteine (Hcy) were estimated by serum creatinine (SCr), uric acid (SCr),) (UA), and the distribution characteristics of urinary mALB/Cr in healthy population were analyzed. The relationship between urinary mALB/Cr and related metabolic indexes, and the independent risk factors of microalbuminuria (MAU). Results the median urinary mALB/Cr (quartile spacing) of 14,184 subjects in the analysis was 5.7 (3.1 / 11.8) mg/g, including 5.4 (3.011.3) mg/g, / female 6.3 (3.6 / 13.2) mg/g, for males. The total positive rate of urinary mALB/Cr (mALB/Cr 鈮，
本文編號(hào)：2340427
[Abstract]:Objective to investigate the distribution of urinary albumin creatinine ratio (mALB/Cr) and its relationship with related metabolic indexes. Methods from November 2013 to October 2014, the body mass index (BMI), (SBP), diastolic blood pressure (DBP), waist circumference, hip circumference and waist-to-hip ratio (WHR),) of 4,184 subjects with urinary mALB/Cr were collected. Urine mALB/Cr and blood glucose (GLU), lipids (total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C) low density lipoprotein cholesterol (LDL-C),) renal function (urea nitrogen (BUN),) The serum levels of cystatin C (Cys-C) and glomerular filtration rate (eGFR),) homocysteine (Hcy) were estimated by serum creatinine (SCr), uric acid (SCr),) (UA), and the distribution characteristics of urinary mALB/Cr in healthy population were analyzed. The relationship between urinary mALB/Cr and related metabolic indexes, and the independent risk factors of microalbuminuria (MAU). Results the median urinary mALB/Cr (quartile spacing) of 14,184 subjects in the analysis was 5.7 (3.1 / 11.8) mg/g, including 5.4 (3.011.3) mg/g, / female 6.3 (3.6 / 13.2) mg/g, for males. The total positive rate of urinary mALB/Cr (mALB/Cr 鈮，
本文編號(hào)：2340427
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