【摘要】：目的了解上海市醫(yī)務(wù)人員(Healthcare Workers,HCWs)麻疹、風(fēng)疹及流行性腮腺炎(流腮)的抗體水平,為制定針對性的免疫策略提供依據(jù)。方法采集全市4家一級醫(yī)院、3家二級醫(yī)院、2家三級醫(yī)院的HCWs的全血標(biāo)本700份,檢測血清麻疹、風(fēng)疹及流腮Ig G抗體。結(jié)果 HCWs麻疹抗體陽性率為97.00%,幾何平均濃度(Geometric Mean Concentration,GMC)為946.82 mIU/ml,不同年齡組、戶籍類型、醫(yī)院級別、科室類型、免疫史、患病史HCWs間麻疹抗體陽性率無統(tǒng)計學(xué)差異。風(fēng)疹抗體陽性率為81.29%,GMC為39.16 IU/ml。流腮抗體陽性率為83.43%,GMC為225.03 IU/ml。Logistic回歸結(jié)果顯示,20~39歲HCWs風(fēng)疹抗體陽性率高于40歲及以上HCWs;一級醫(yī)院HCWs風(fēng)疹抗體陽性率高于二、三級醫(yī)院HCWs。50歲及以上HCWs流腮抗體水平高于20~49歲HCWs;一、二級醫(yī)院HCWs流腮抗體水平高于三級醫(yī)院HCWs。結(jié)論 HCWs對麻疹普遍免疫,但對既往無明確免疫史的HCWs,尤其是新進(jìn)職工、護(hù)工、醫(yī)學(xué)院研究生等對象開展含麻疹成分疫苗查漏補(bǔ)種仍有必要。同時加強(qiáng)對二、三級醫(yī)院HCWs的宣傳動員,進(jìn)一步提高接種率,通過接種麻疹風(fēng)疹或麻腮風(fēng)聯(lián)合減毒活疫苗控制HCWs中風(fēng)疹和流腮的發(fā)病。
[Abstract]:Objective to investigate the antibody levels of measles, rubella and mumps (gills) in medical workers (Healthcare Workers,HCWs) in Shanghai. Methods 700 whole blood samples of HCWs were collected from 4 first class hospitals, 3 second class hospitals and 2 third class hospitals. The serum measles, rubella and Ig G antibodies were detected. Results the positive rate of HCWs measles antibody was 97.00 and the geometric mean concentration (Geometric Mean Concentration,GMC) was 946.82 mIU/ml, in different age groups, household registration type, hospital grade, department type, immune history. There was no significant difference in measles antibody positive rate between HCWs patients. The positive rate of rubella antibody was 81.29 and 39.16 IU/ml.. The positive rate of HCWs rubella antibody in 20- 39 years old was higher than that of 40 years old and over HCWs;. The positive rate of GMC was 225.03 IU/ml.Logistic. The results showed that the positive rate of HCWs rubella antibody was higher at 20 ~ 39 years old than that of 40 years old. The positive rate of HCWs rubella antibody in the first class hospital was higher than that in the second grade hospital. The level of HCWs gills antibody in the third class hospital was higher than that in the third class hospital, and the level of HCWs antibody in the second class hospital was higher than that in the third class hospital HCWs.. Conclusion HCWs is widely immunized against measles, but it is still necessary for HCWs, especially for new workers, nursing workers and graduate students of medical school, to detect measles vaccine. At the same time, we should strengthen the propaganda and mobilization of HCWs in the second and third level hospitals, further improve the vaccination rate, and control the incidence of rubella and gills in HCWs by inoculating measles rubella or leprosy with live attenuated vaccine.
【作者單位】： 上海市疾病預(yù)防控制中心;復(fù)旦大學(xué)公共衛(wèi)生學(xué)院;
【基金】：上海市第四輪公共衛(wèi)生三年行動計劃重點(diǎn)學(xué)科建設(shè)項目-傳染病與衛(wèi)生微生物學(xué)(編號:15GWZK0101)
【分類號】：R446.6

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