發(fā)布時間：2018-10-16 10:51

【摘要】：目的研究布洛芬存在時臨床分離假絲酵母菌對氟康唑的耐藥性,明確布洛芬對臨床分離假絲酵母菌耐氟康唑的逆轉(zhuǎn)作用。方法收集醫(yī)院2014年2月-2016年2月臨床標(biāo)本中分離的假絲酵母菌308株,采用ATB Fungus 3真菌藥敏試驗條進(jìn)行藥敏試驗,以及布洛芬存在情況下,假絲酵母菌對氟康唑MIC值的變化。結(jié)果分離308株假絲酵母菌中,有62株為耐藥菌株,其中白假絲酵母菌2株,熱帶假絲酵母菌30株,光滑假絲酵母菌4株,近平滑假絲酵母菌18株及克柔假絲酵母菌8株;加入布洛芬后,有35株假絲酵母菌對氟康唑的耐藥性發(fā)生了逆轉(zhuǎn),其中白假絲酵母菌逆轉(zhuǎn)率為100.00%,熱帶假絲酵母菌、近平滑假絲酵母菌和克柔假絲酵母菌逆轉(zhuǎn)率分別為53.33%、83.33%和25.00%,而光滑假絲酵母菌逆轉(zhuǎn)率為0,差異有統(tǒng)計學(xué)意義(P0.05)。結(jié)論布洛芬對假絲酵母菌耐氟康唑具有一定逆轉(zhuǎn)作用,為今后臨床治療耐氟康唑的假絲酵母菌提供了一個潛在的治療選擇。
[Abstract]:Objective to study the resistance of clinical isolated Candida cerevisiae to fluconazole in the presence of ibuprofen, and to determine the reversal effect of ibuprofen on fluconazole resistance of clinically isolated Candida cerevisiae. Methods 308 strains of Candida cerevisiae isolated from clinical specimens from Feb 2014 to Feb 2016 were collected and tested with ATB Fungus 3 fungal susceptibility test strip. The changes of MIC value of Candida cerevisiae to fluconazole in the presence of ibuprofen were studied. Results among 308 Candida cerevisiae isolates, 62 were drug-resistant, including 2 Candida albicans, 30 Candida tropicalis, 4 Candida smooth, 18 Candida near smooth and 8 Candida krrostris, among which 2 were Candida albicans, 30 were Candida tropicalis, 4 were Candida smooth, 18 were near Candida smoothing and 8 were Candida cerevisiae. After ibuprofen was added, the resistance of 35 Candida cerevisiae to fluconazole was reversed, and the reversal rate of Candida albicans was 100.00. The reverse rates of nearly smooth Candida cerevisiae and Candida krorostris were 53.33% and 25.00%, respectively, while the reverse rate of Candida smooth was 0, the difference was statistically significant (P0.05). Conclusion ibuprofen can reverse fluconazole resistance of Candida cerevisiae and provide a potential therapeutic option for the treatment of fluconazole-resistant Candida cerevisiae in the future.
【作者單位】： 紹興市立醫(yī)院檢驗科;
【分類號】：R446.5

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