【摘要】：目的探討患者及獻(xiàn)血者人群中紅細(xì)胞血型不規(guī)則抗體的發(fā)生頻率及分布特點。方法收集本院臨床紅細(xì)胞標(biāo)本32 496(人)份及獻(xiàn)血者標(biāo)本30 592(人)份,應(yīng)用鹽水法、試管抗球蛋白法、微柱凝膠法和各種血型定型試劑檢定紅細(xì)胞不規(guī)則抗體的特異性;調(diào)查紅細(xì)胞不規(guī)則抗體患者的性別比例、有無輸血史及妊娠史。結(jié)果本組紅細(xì)胞血型不規(guī)則抗體篩選陽性率0.36%(230/63 080),其中同種抗體占93.04%(214/230),同種抗體+自身抗體0.43%(1/230),自身抗體占1.73%(4/230)例,未確定特異性的同種抗體占4.78%(11/230)。特異性抗體中,89.50%(196/219)來源于患者、發(fā)生頻率0.31%(196/63 080),10.50%(23/219)來自獻(xiàn)血者、發(fā)生頻率0.04%(23/63 080)。結(jié)論患者不規(guī)則抗體發(fā)生頻率明顯高于獻(xiàn)血者;為了避免患者免疫性輸血反應(yīng)的發(fā)生,減少獻(xiàn)血者不規(guī)則抗體的輸入,輸血前全面開展紅細(xì)胞同種免疫抗體篩檢,對獻(xiàn)血者血漿做次側(cè)交叉配血,提高臨床輸血的安全性和有效性。
[Abstract]:Objective to investigate the frequency and distribution of irregular antibodies against erythrocyte blood group in patients and blood donors. Methods A total of 32 496 (human) and 30 592 (human) blood donors were collected in our hospital. The specificity of irregular antibodies of erythrocytes was detected by salt water method, tube antiglobulin method, microcolumn gel method and various blood typing reagents. To investigate the sex ratio, blood transfusion history and pregnancy history of patients with irregular antibodies to erythrocytes. Results the positive rate of irregular antibodies of erythrocyte blood group was 0.36% (230 / 63,080), of which alloantibodies were 93.04% (214 / 230), autoantibodies were 0.43% (1 / 230), autoantibodies were 1.73% (4 / 230), and undetermined specific autoantibodies were 4.78% (11 / 230). Of the specific antibodies, 89.50% (196 / 219) were from patients, and 0.31% (196 / 63,080) and 10.50% (23 / 219) were from donors. The frequency of occurrence was 0.04% (23 / 63,080). Conclusion the frequency of irregular antibodies in patients is significantly higher than that in blood donors. In order to improve the safety and effectiveness of clinical blood transfusion, blood donors were matched with subside cross blood.
【作者單位】： 蘇州大學(xué)附屬第二醫(yī)院輸血科;宿遷市第一人民醫(yī)院;天津市疾病預(yù)防控制中心;
【分類號】：R457.1
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本文編號：2200805