本文選題：他汀類藥物 + 膿毒癥��； 參考：《中國(guó)老年學(xué)雜志》2016年22期

【摘要】：目的觀察他汀類藥物在老年重癥監(jiān)護(hù)室(ICU)膿毒癥患者中的應(yīng)用價(jià)值及作用機(jī)制。方法回顧性分析98例老年ICU膿毒癥患者治療和隨訪資料,并按照是否服用他汀類藥物分為服用組(56例)和未服用組(42例)。對(duì)比ICU滯留時(shí)間、機(jī)械通氣天數(shù)、連續(xù)腎臟替代治療(CRRT)時(shí)間,并統(tǒng)計(jì)治療前、治療7 d后C反應(yīng)蛋白(CRP)、白細(xì)胞介素(IL)-6、腫瘤壞死因子(TNF)-α、超氧化物歧化酶(SOD)水平變化,并統(tǒng)計(jì)治療28 d內(nèi)存活率。結(jié)果服用組ICU滯留時(shí)間、機(jī)械通氣天數(shù)、CRRT時(shí)間均明顯少于未服用組(P0.05);治療前兩組CRP、IL-6、TNF-α、SOD水平均無(wú)顯著差異(P0.05),7 d后兩組SOD均較治療前顯著升高(P0.05),其他因子水平均較治療前顯著降低(P0.05),且7 d后服用組CRP、IL-6、TNF-α、SOD與未服用組間均存在顯著差異(P0.05);服用組28 d存活率為85.71%,遠(yuǎn)高于未服用組(66.67%,P0.05)。結(jié)論他汀類藥物在老年ICU膿毒癥患者中應(yīng)用可顯著縮短治療時(shí)間、提高28 d存活率,與減輕炎癥反應(yīng)、提升氧自由基清除能力有關(guān)。
[Abstract]:Objective to observe the application value and mechanism of statins in geriatric intensive care unit (ICU) patients with sepsis. Methods the data of 98 patients with sepsis in elderly ICU were analyzed retrospectively. According to whether to take statins or not, they were divided into two groups: taking group (n = 56) and non-taking group (n = 42). The retention time of ICU, the days of mechanical ventilation, the time of continuous renal replacement therapy (CRRT), and the changes of C-reactive protein (CRP), interleukin (IL) -6, tumor necrosis factor (TNF)-偽 and superoxide dismutase (SOD) before and 7 days after treatment were compared. The survival rate within 28 days was counted. Results the retention time of ICU in the taking group, The CRRT time of mechanical ventilation was significantly shorter than that of the control group (P0.05), and there was no significant difference between the two groups before and after treatment (P0.05). After 7 days of treatment, the level of SOD in the two groups was significantly higher than that before treatment (P0.05), and the level of other factors was significantly lower than that before treatment (P0.05), and the level of other factors was significantly lower than that before treatment (P0.05), and after 7 days of treatment, the level of SOD in the two groups was significantly higher than that before treatment (P0.05). There was significant difference between the two groups (P0.05), and the 28d survival rate was 85.71, which was much higher than that in the control group (66.67g / kg, P0.05). Conclusion the application of statins in geriatric ICU patients with sepsis can significantly shorten the treatment time and increase the survival rate of 28 days, which is related to reducing inflammation and improving the ability of scavenging oxygen free radicals.
【作者單位】： 廣州醫(yī)科大學(xué)附屬深圳沙井醫(yī)院;
【基金】：深圳市寶安區(qū)科技創(chuàng)新局項(xiàng)目(深寶科2015195號(hào))
【分類號(hào)】：R459.7

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