本文選題：細菌 + 耐藥性�。� 參考：《安徽醫(yī)科大學(xué)》2015年碩士論文

【摘要】：目的了解2013年安徽省立醫(yī)院普通科室分離菌和ICU分離菌之間細菌分布和對抗菌藥物耐藥性的分析研究。方法收集我院2013年1月~12月年臨床各科室送檢的病原體分離培養(yǎng)與鑒定,并對ICU與普通科室分離的病原體的分布及耐藥性進行對比分析。同時對ICU臨床分離菌的分布和耐藥情況和普通科室分離菌進行比較性研究。結(jié)果2013年全院共分離4052株,其中普通科室3068株,ICU 984株,均以桿菌為主,其中普通科室桿菌依次為大腸埃希菌、銅綠假單胞菌、肺炎克雷伯桿菌和鮑曼不動桿菌,共占48.5%,球菌主要為金黃色葡萄球菌及腸球菌,共占13.3%,;而ICU依次為鮑曼不動桿菌、銅綠假單胞菌、肺炎克雷伯桿菌、大腸埃希菌,共占64.0%,球菌為腸球菌及金黃色葡萄球菌,共占11.2%;普通科室分離大腸埃希菌、肺炎克雷伯桿菌、銅綠假單胞菌對碳青霉烯敏感性較高,分別在90.0%、80.0%、60.0%以上,而鮑曼不動桿菌只有29.7%敏感;普通科室分離金黃色葡萄球菌對苯唑西林敏感率54.7%,而ICU分離的除大腸埃希菌對亞胺培南敏感性為98.5%,銅綠假單胞菌及肺炎克雷伯敏感率僅達到50.0%,鮑曼不動桿菌耐藥嚴(yán)重,敏感率只有6.0%,球菌屬對苯唑西林敏感率只有33.3%,統(tǒng)計后較普通科室無明顯差異。結(jié)論1.ICU分離菌和普通科室分離菌分布及耐藥性情況(尤其是革蘭陰性桿菌)存在明顯差異。2.ICU分離菌陰性桿菌及耐藥性較普通科室明顯增加。3.需定期進行全院及ICU細菌耐藥性監(jiān)測,將有助了解ICU細菌的分布和耐藥情況,從而指導(dǎo)臨床合理用藥。
[Abstract]:Objective to investigate the distribution of bacteria and antimicrobial resistance between bacteria isolated from general departments and ICU isolates in Anhui Provincial Hospital in 2013. Methods the pathogen isolation culture and identification were collected from January to December 2013 in our hospital. The distribution and drug resistance of pathogens isolated from ICU and general departments were compared and analyzed. At the same time, the distribution and drug resistance of clinical isolates of ICU were compared with those isolated from general departments. Results A total of 4052 strains were isolated in our hospital in 2013, of which 3068 strains were isolated from the general department, all of which were mainly bacilli. Among them, Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae and Acinetobacter baumannii were the most common bacteria. The ICU were Acinetobacter baumannii, Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli, Escherichia coli, 64.0. Escherichia coli Klebsiella pneumoniae Pseudomonas aeruginosa and Pseudomonas aeruginosa were more sensitive to carbapenem than those of Acinetobacter baumannii and Acinetobacter baumannii respectively. The sensitivity rate of Staphylococcus aureus to oxacillin was 54.7%, while the sensitivity of Escherichia coli isolated by ICU to imipenem was 98.5m. The sensitivity rate of Pseudomonas aeruginosa and Klebsiella pneumoniae was only 50.0%, and Acinetobacter baumannii resistance was serious. The sensitivity rate was only 6.0 and the sensitivity rate to oxacillin was only 33.30.There was no significant difference between the two groups after statistics. Conclusion there are significant differences in the distribution and drug resistance between 1.ICU isolates and general departments, especially Gram-negative bacilli. It is necessary to monitor the drug resistance of the whole hospital and ICU bacteria regularly, which will help to understand the distribution and drug resistance of ICU bacteria and guide the rational use of drugs in clinic.
【學(xué)位授予單位】：安徽醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2015
【分類號】：R446.5

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本文編號：1979504