本文選題：帕羅西汀 + 唑吡坦�。� 參考：《中國臨床藥理學(xué)雜志》2016年09期

【摘要】：目的觀察帕羅西汀聯(lián)合唑吡坦與單用唑吡坦治療原發(fā)性失眠的臨床療效與安全性。方法 57例原發(fā)性失眠患者隨機(jī)分為試驗(yàn)組29例和對(duì)照組28例。試驗(yàn)組口服帕羅西汀10~20 mg·d~(-1),唑吡坦5~10 mg·d~(-1);對(duì)照組口服唑吡坦5~10 mg·d~(-1),2組療程均為8周。治療前后分別用多導(dǎo)睡眠圖和匹茲堡睡眠質(zhì)量指數(shù)量表評(píng)價(jià)2組的臨床療效;用不良反應(yīng)癥狀量表(TESS)評(píng)估安全性。結(jié)果治療后,試驗(yàn)組入睡時(shí)間、覺醒時(shí)間、睡眠時(shí)間分別為(29.60±4.80),(81.65±33.11),(388.75±32.81)min,顯著優(yōu)于對(duì)照組的(35.00±3.91),(121.29±32.48),(339.51±35.26)min(P0.05)。試驗(yàn)組的睡眠效率為(82.67±6.88)%,顯著優(yōu)于對(duì)照組的(73.69±7.01)%(P0.05)。試驗(yàn)組匹茲堡睡眠質(zhì)量指數(shù)總分為(6.07±2.05),顯著低于對(duì)照組的(8.57±2.47)(P0.05)。試驗(yàn)組不良反應(yīng)發(fā)生率為27.59%,顯著高于對(duì)照組的7.14%(P0.05)。結(jié)論帕羅西汀聯(lián)合唑吡坦治療原發(fā)性失眠患者療效更優(yōu),且安全性高。
[Abstract]:Objective to observe the efficacy and safety of paroxetine combined with zolpidem and zolpidem alone in the treatment of primary insomnia. Methods 57 patients with primary insomnia were randomly divided into trial group (n = 29) and control group (n = 28). The experimental group was treated with paroxetine 1020 mg / d, zolpidem 10 mg / d ~ (-1) with zolpidem 10 mg / d and the control group with zolpidem 10 mg / d ~ (-1) for 8 weeks. The clinical efficacy of the two groups was evaluated by polysomnography and Pittsburgh Sleep quality Index scale before and after treatment, and the safety was evaluated with the adverse reaction symptom scale (TESS). Results after treatment, the sleep time, awakening time and sleep time in the experimental group were 29.60 鹵4.80 and 388.75 鹵32.81 min, respectively, which were significantly higher than those in the control group (121.29 鹵32.48 min, 339.51 鹵35.26 min, P 0.05). The sleep efficiency of the experimental group was 82.67 鹵6.88, which was significantly better than that of the control group (73.69 鹵7.01). The total score of Pittsburgh sleep quality index in the trial group was 6.07 鹵2.05, which was significantly lower than that in the control group (8.57 鹵2.47). The incidence of adverse reactions in the trial group was 27.59, which was significantly higher than that in the control group (7.14%, P 0.05). Conclusion Paroxetine combined with zolpidem is more effective and safe in the treatment of primary insomnia.
【作者單位】： 杭州市第七人民醫(yī)院醫(yī)學(xué)心理科;杭州市第七人民醫(yī)院科教科;
【基金】：浙江省自然科學(xué)基金資助項(xiàng)目(LQ13H090003) 杭州市重點(diǎn)�？茖２』鹳Y助項(xiàng)目(20140733Q44)
【分類號(hào)】：R740

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