本文選題：G-耐藥菌 + “超級(jí)細(xì)菌”��； 參考：《中國(guó)新藥雜志》2016年03期

【摘要】：革蘭陰性(G-)菌耐藥問題日益嚴(yán)峻,產(chǎn)新德里金屬-β-內(nèi)酰胺酶-1(New Delhi metallo-β-lactamase-1,NDM-1)的"超級(jí)細(xì)菌"的出現(xiàn)使G-菌耐藥問題引起全球廣泛關(guān)注。產(chǎn)NDM-1的細(xì)菌對(duì)幾乎所有β-內(nèi)酰胺類抗生素耐藥,使G-菌的臨床治療面臨巨大挑戰(zhàn),研制可有效殺滅"超級(jí)細(xì)菌"等G-耐藥菌的新型抗感染藥物迫在眉睫。本文綜述了NDM-1酶及其抑制劑的研究進(jìn)展,為研制以NDM-1為靶點(diǎn)的抗耐藥G-菌的新型藥物,有效殺滅"超級(jí)細(xì)菌"提供借鑒。
[Abstract]:The problem of drug resistance of Gram-negative G-lactamases is becoming more and more serious. The emergence of "super bacteria" producing New Delhi metallo- 尾 -lactamase-1 (NDM-1) makes the drug resistance of G- bacteria attract worldwide attention. The NDM-1 producing bacteria are resistant to almost all 尾 -lactam antibiotics, which makes the clinical treatment of G- bacteria face great challenge. It is urgent to develop new anti-infective drugs that can effectively kill "super bacteria" and other G- resistant bacteria. In this paper, the research progress of NDM-1 enzyme and its inhibitors is reviewed, which can be used as a reference for the development of novel drug resistant drugs against G- resistant bacteria targeting NDM-1 and the killing of "super bacteria".
【作者單位】： 中國(guó)醫(yī)學(xué)科學(xué)院北京協(xié)和醫(yī)學(xué)院醫(yī)藥生物技術(shù)研究所;
【基金】：國(guó)家“重大新藥創(chuàng)制”科技重大專項(xiàng)(2014ZX09507-009-008)
【分類號(hào)】：R446.5
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本文編號(hào)：1920133