本文選題：原發(fā)性失眠癥 + 認(rèn)知功能　； 參考：《蘇州大學(xué)》2015年碩士論文

【摘要】：目的:(1)探討原發(fā)性失眠癥患者認(rèn)知功能損害的特點(diǎn)及影響因素,為失眠癥患者認(rèn)知功能的神經(jīng)心理學(xué)研究提供一定的理論依據(jù)。(2)探討原發(fā)性失眠癥患者的生活質(zhì)量及相關(guān)影響因素,為改善失眠患者的生活質(zhì)量提供一定的科學(xué)依據(jù)。方法:(1)采用神經(jīng)心理測(cè)驗(yàn)包括韋氏記憶(數(shù)字累加、視覺(jué)再認(rèn)、視覺(jué)再生、聯(lián)想學(xué)習(xí))、數(shù)字廣度、數(shù)字化消、連線測(cè)驗(yàn)TMT、威斯康辛卡片分類測(cè)驗(yàn)(WCST)分別對(duì)46例原發(fā)性失眠癥患者(PI組)及40名健康對(duì)照者(HC組)進(jìn)行注意力、記憶力、執(zhí)行功能等方面的測(cè)評(píng);(2)采用世界衛(wèi)生組織生活質(zhì)量評(píng)估量表(WHOQOL)分別對(duì)50例原發(fā)性失眠癥患者和40名健康對(duì)照組進(jìn)行生活質(zhì)量(QOL)的評(píng)估;(3)應(yīng)用匹茲堡睡眠質(zhì)量指數(shù)量表(PSQI)、抑郁自評(píng)量表(SDS)、焦慮自評(píng)量表(SAS)評(píng)定原發(fā)性失眠癥患者的病情及焦慮抑郁程度。結(jié)果:(1)原發(fā)性失眠癥患者的認(rèn)知功能損害特點(diǎn)及影響因素:?PI組在數(shù)字累加、視覺(jué)再認(rèn)、視覺(jué)再生、聯(lián)想學(xué)習(xí)、數(shù)字倒背、注意力失誤率、連線測(cè)驗(yàn)B及B-A完成時(shí)間和威斯康辛卡片測(cè)驗(yàn)各項(xiàng)成績(jī)(正確應(yīng)答數(shù)除外)均低于HC組。?PI組患者SDS分與PSOI、SAS分成正相關(guān);數(shù)字累加分與病程成負(fù)相關(guān);聯(lián)想學(xué)習(xí)分與PSQI成負(fù)相關(guān);連線測(cè)驗(yàn)B及連線測(cè)驗(yàn)B-A的時(shí)間與病程成正相關(guān);WCST持續(xù)錯(cuò)誤百分比與SDS成正相關(guān)。(2)原發(fā)性失眠癥患者的生活質(zhì)量及影響因素:?PI組在生理領(lǐng)域、心理領(lǐng)域、獨(dú)立性領(lǐng)域、社會(huì)關(guān)系領(lǐng)域、環(huán)境領(lǐng)域和總體生活質(zhì)量中評(píng)分均低于HC組。?PI組重度失眠組總體生活質(zhì)量低于中度失眠組,焦慮抑郁共存組的總體生活質(zhì)量低于無(wú)焦慮抑郁組。?在相關(guān)分析中,SAS分與各領(lǐng)域(精神支柱領(lǐng)域除外)和總體生活質(zhì)量成負(fù)相關(guān);SDS分與各領(lǐng)域和總體生活質(zhì)量成負(fù)相關(guān);PSQI分與生理領(lǐng)域、心理領(lǐng)域、獨(dú)立性領(lǐng)域、精神支柱領(lǐng)域和總體生活質(zhì)量成負(fù)相關(guān)。?在多元逐步回歸分析中,SDS分、PSQI分、家族史等3個(gè)自變量成為影響患者生活質(zhì)量總分的主要因素。結(jié)論:(1)原發(fā)性失眠癥患者存在記憶力、注意力、執(zhí)行功能等認(rèn)知功能的損害。(2)病程的長(zhǎng)短,病情的嚴(yán)重程度以及伴發(fā)的焦慮抑郁情緒是導(dǎo)致認(rèn)知功能損害的相關(guān)影響因素。(3)原發(fā)性失眠癥患者的生活質(zhì)量在生理、心理、獨(dú)立性、社會(huì)關(guān)系、環(huán)境等維度和總體生活質(zhì)量都有顯著降低。(4)失眠所伴隨的焦慮抑郁情緒,失眠的嚴(yán)重程度和有無(wú)家族史是影響原發(fā)性失眠癥患者生活質(zhì)量的主要因素。
[Abstract]:Objective to explore the characteristics and influencing factors of cognitive impairment in patients with primary insomnia. To provide a certain theoretical basis for neuropsychological research on cognitive function of patients with insomnia. (2) to explore the quality of life of patients with primary insomnia and related influencing factors, and to provide a scientific basis for improving the quality of life of patients with insomnia. Methods the neuropsychological test included Wechsler's memory (digital accumulation, visual recognition, visual regeneration, associative learning, digital span, digital elimination). Wired test (TMT), Wisconsin card sorting test (WCST) for 46 patients with primary insomnia (Pi group) and 40 healthy controls (group HC) for attention and memory, Quality of life (QOL) of 50 patients with primary insomnia and 40 healthy controls were evaluated by the World Health Organization quality of Life Assessment scale (WHOQOL) and the Pittsburgh Sleep quality Index (Pittsburgh Sleep quality Index) was used to evaluate the quality of life of 50 patients with primary insomnia and 40 healthy controls. PSQI, SDS and SAS were used to evaluate the condition and degree of anxiety and depression in patients with primary insomnia. Results the cognitive impairment characteristics of patients with primary insomnia and their influencing factors: the accumulation of numbers, visual recognition, visual regeneration, associative learning, digital backside, and attention failure rate. The completion time of B and B-A and the scores of Wisconsin card test (except correct response) were lower than those of HC group and Pi group, the scores of SDS and PSOISAs were positively correlated, the cumulative scores of numbers were negatively correlated with the course of disease, the scores of associative learning were negatively correlated with PSQI. There was a positive correlation between the duration of WCST and the duration of disease course. The percentage of persistent errors in WCST was positively correlated with SDS. 2) the quality of life of patients with primary insomnia and its influencing factors were in physiological, psychological and independence fields. The scores of social relations, environmental field and total quality of life were lower than those of HC group. The total quality of life of severe insomnia group was lower than that of moderate insomnia group, and the overall quality of life of anxiety depression coexisting group was lower than that of non-anxiety depression group. In the correlation analysis, the scores of SAS were negatively correlated with the fields (except for the spiritual pillar) and the total quality of life. The SDS scores were negatively correlated with the fields and the overall quality of life. The scores of PSQI were negatively correlated with the physiological, psychological, and independent fields. Pillar area and overall quality of life negatively. In multivariate stepwise regression analysis, three independent variables, such as SDS score, PSQI score and family history, were the main factors affecting patients' total quality of life score. Conclusion (1) patients with primary insomnia have cognitive impairment, such as memory, attention, executive function, etc. The severity of the illness and the associated anxiety and depression are the related factors that lead to cognitive impairment. The quality of life of patients with primary insomnia is physiological, psychological, independent, social relations. The anxiety and depression associated with insomnia were significantly decreased in the dimensions of environment and overall quality of life. The severity of insomnia and the existence of family history were the main factors affecting the quality of life of patients with primary insomnia.
【學(xué)位授予單位】：蘇州大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2015
【分類號(hào)】：R740

【參考文獻(xiàn)】

相關(guān)期刊論文 前1條

1 賈燕燕;張紅菊;張斌;韓繼祥;張杰文;;原發(fā)性失眠患者神經(jīng)心理及認(rèn)知功能研究[J];國(guó)際神經(jīng)病學(xué)神經(jīng)外科學(xué)雜志;2014年04期

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本文編號(hào)：1872091