發(fā)布時(shí)間：2018-04-29 08:50

  本文選題：微量元素 + 宏量元素��； 參考：《吉林大學(xué)》2015年碩士論文

【摘要】：目的微量元素（鐵、鋅、銅）和宏量元素（鎂、鈣、磷）是構(gòu)成人類機(jī)體的重要物質(zhì)，維持著人體正�；顒�(dòng)和代謝，對(duì)人體健康起著重要的作用。這六種元素不僅參與體內(nèi)細(xì)胞分裂、核酸的形成、骨骼的骨化，同時(shí)還參與人體的內(nèi)分泌及免疫等過程。它們水平缺乏或過量均可導(dǎo)致疾病。兒童因處于生長發(fā)育的關(guān)鍵時(shí)期，并且消化系統(tǒng)發(fā)育還不成熟，胃酸和消化酶分泌少，酶活力偏低，同時(shí)兒童易出現(xiàn)消化系統(tǒng)功能紊亂，影響營養(yǎng)吸收，容易出現(xiàn)鐵、鎂、鋅、銅、鈣、磷水平失衡。各元素吸收、代謝等過程中存在相互作用，一種元素缺乏或過量，容易引起其他元素水平失衡。本文研究了不同年齡兒童血清鐵、鎂、鋅、銅、鈣、磷水平，以及各元素之間的相互作用，為防治元素失衡引發(fā)的疾病提供依據(jù)。 方法回顧性分析了2014年1月至2014年12月來我院就診的兒童1040名，其中嬰兒組（1歲）200人，男孩128人，女孩72人，幼兒組（1-2歲）200人，男孩108人，女孩92人，學(xué)齡前期組（3-6歲）為240人，男孩140人，女孩100人，學(xué)齡期組（7-12歲）200人，男孩132人，女孩68人，青春期組（13-14歲）為200人，男孩112人，女孩88人�；純壕扇§o脈血2ml，采用全自動(dòng)生化分析儀（日立7600-210）進(jìn)行檢測(cè)血清鐵、鎂、鋅、銅、鈣、磷。全部數(shù)據(jù)采用SPSS21.0分析軟件進(jìn)行處理。各元素水平符合正態(tài)分布采用x±s表示，各年齡段各元素水平兩兩比較時(shí)，方差不具齊性，故采用秩和檢驗(yàn)進(jìn)行分析，以P＜0.005為差異有統(tǒng)計(jì)學(xué)意義。各元素之間行Pearson相關(guān)分析，均以P＜0.05為差異有統(tǒng)計(jì)學(xué)意義。 結(jié)果 （1）六種元素中，除嬰幼兒組血清鋅低于正常范圍，，其余各年齡組六種元素血清水平均在正常值范圍。嬰兒期血清鐵、鎂、鋅的水平明顯低于年長兒組。幼兒期血清鐵、鋅的水平明顯低于學(xué)齡期及青春期的水平，血清銅的水平明顯高于學(xué)齡期及青春期。學(xué)齡前期血清鐵水平明顯低于學(xué)齡期及青春期。 （2）相關(guān)分析表明：血清鐵水平與血清鋅水平呈顯正相關(guān)，r=0.366，P0.001，血清鐵與銅呈負(fù)相關(guān)，r=-0.275，P0.001，血清鋅與銅呈負(fù)相關(guān)，r=-0.162，P=0.009，血清鋅與鈣呈正相關(guān)，r=0.156，P=0.012，血清鈣與磷呈負(fù)相關(guān)，r=-0.256，P0.001。其余各元素之間無顯著性相關(guān)。 結(jié)論 （1）對(duì)某一元素缺乏的兒童則應(yīng)在膳食外給予額外補(bǔ)充。 （2）本文研究結(jié)果提示嬰兒期存在鋅缺乏，鐵、鎂水平低于年長兒，需補(bǔ)充鋅元素，同時(shí)需加強(qiáng)膳食中鐵、鎂元素的攝入和平衡；幼兒期存在鋅缺乏，鐵水平低于年長兒，故需補(bǔ)充鋅的同時(shí)，注意鐵元素的攝入和平衡；學(xué)齡前期兒童需注意鐵元素的補(bǔ)充。 （3）因鋅、鐵、銅等元素之間存在相互作用，故補(bǔ)充某一元素時(shí)需注意劑量適當(dāng)，兩種以上元素同時(shí)補(bǔ)充時(shí)則需注意元素之間的比例和平衡。
[Abstract]:Objective Trace elements (iron, zinc, copper) and macroelements (magnesium, calcium, phosphorus) are important substances that constitute human body, maintain normal activity and metabolism of human body, and play an important role in human health. These six elements not only participate in cell division, nucleic acid formation, bone ossification, but also participate in endocrine and immune processes. Their lack or overdose can lead to disease. Children are in the critical period of growth and development, and the digestive system is not mature, gastric acid and digestive enzyme secretion is low, enzyme activity is low, and children are prone to digestive system dysfunction, affecting nutrition absorption, iron, magnesium, zinc, iron, magnesium and zinc, The levels of copper, calcium and phosphorus are out of balance. In the process of absorption and metabolism of various elements, there is interaction, and one element is deficient or excessive, which can easily cause the imbalance of other elements. The levels of serum iron, magnesium, zinc, copper, calcium and phosphorus in children of different ages were studied in this paper. Methods from January 2014 to December 2014, 1040 children in our hospital were retrospectively analyzed, including 128,128 boys, 72 girls, 200 young children aged 1-2 years, 108 boys and 92 girls in the infant group. In the preschool group, 240 persons (aged 3-6 years), 140 boys, 100 girls, 200 boys aged 7-12 years, 132 boys, 68 girls, and 13-14 years old in puberty group were 200, 112 boys and 88 girls. The serum iron, magnesium, zinc, copper, calcium and phosphorus were detected by automatic biochemical analyzer (Hitachi 7600-210). All data are processed by SPSS21.0 software. The level of each element was expressed as x 鹵s in accordance with normal distribution, and the variance was not homogeneous when compared with each other in different age groups. Therefore, rank sum test was used to analyze, and the difference was statistically significant (P < 0.005). There were significant differences in Pearson correlation among all the elements (P < 0. 05). Result 1) among the six elements, the serum zinc levels of the six elements were in the normal range except for the infants and young children, and the serum levels of the other six elements in each age group were in the normal range. The levels of serum iron, magnesium and zinc in infants were significantly lower than those in older infants. The levels of serum iron and zinc were significantly lower than those of school age and puberty, and the levels of serum copper were significantly higher than those of school age and puberty. The serum iron level in pre-school age was significantly lower than that in school age and puberty. (2) correlation analysis showed that there was a positive correlation between serum iron level and serum zinc level, a negative correlation between serum iron and copper, a negative correlation between serum zinc and copper, a positive correlation between serum zinc and calcium, and a negative correlation between serum calcium and phosphorus, a negative correlation between serum Zn and P, a negative correlation between serum Zn and Cu, a positive correlation between serum Zn and Ca, and a negative correlation between serum Ca and P, P 0.001. There was no significant correlation between the other elements. Conclusion Children who lack an element should be supplemented in addition to the diet. 2) the results of this study suggest that zinc deficiency exists in infancy, iron and magnesium levels are lower than those in older children, zinc should be supplemented, and the intake and balance of iron and magnesium in diet should be strengthened, and zinc deficiency exists in early childhood, and iron level is lower than that of older children. Therefore, attention should be paid to iron intake and balance while zinc supplementation and iron supplementation should be paid attention to in preschool children. 3) due to the interaction among elements such as zinc, iron, copper and so on, it is necessary to pay attention to the appropriate dosage when supplementing one element, and the proportion and balance of elements to be paid attention to when two or more elements are supplemented at the same time.
【學(xué)位授予單位】：吉林大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2015
【分類號(hào)】：R446.1

【相似文獻(xiàn)】

相關(guān)期刊論文 前10條

1 李慧,徐冬梅,張春菊;河南農(nóng)村嬰幼兒血清鐵含量測(cè)定結(jié)果分析[J];河南預(yù)防醫(yī)學(xué)雜志;2002年04期

2 毛遠(yuǎn)麗,王業(yè)東,孫志強(qiáng),李永利,陳小倩,劉志國,劉佳,楊靜,洪煒,郭靜霞;嚴(yán)重急性呼吸綜合征患者血清鐵改變與臨床意義初探[J];臨床檢驗(yàn)雜志;2003年05期

3 徐貴江,李國慶;測(cè)定血清鐵的一種簡(jiǎn)便比色法[J];江蘇大學(xué)學(xué)報(bào)(醫(yī)學(xué)版);2003年03期

4 秦恩強(qiáng);李永利;張新偉;王凝芳;;20例嚴(yán)重急性呼吸道綜合征患者血清鐵的動(dòng)態(tài)變化[J];傳染病信息;2003年02期

5 周麗,段立華,劉小立,劉筱嫻;學(xué)齡前兒童血清鐵水平及影響因素分析[J];中國公共衛(wèi)生;2004年02期

6 曹建明,肖洪武,姜紅鷹,沈財(cái)成,方芳,李敏;新的高靈敏分光光度法在血清鐵測(cè)定中的應(yīng)用[J];中華檢驗(yàn)醫(yī)學(xué)雜志;2004年03期

7 劉少蘭;;血清鐵、鋅、鈣、鎂、磷與妊娠的關(guān)系探討[J];廣東微量元素科學(xué);2005年10期

8 李紅;滕文鋒;孫衛(wèi)民;施麗飛;蔡竹;;新入學(xué)研究生血清鐵、鋅、鈣、鎂含量分析[J];大連醫(yī)科大學(xué)學(xué)報(bào);2007年05期

9 劉建強(qiáng);馬建濱;趙遠(yuǎn);;亞鐵嗪直接比色法測(cè)定血清鐵的方法評(píng)價(jià)[J];青海師范大學(xué)學(xué)報(bào)(自然科學(xué)版);2009年04期

10 朱永華;姜慶波;;血清鐵自動(dòng)化分析及其在腎病綜合征中的臨床意義[J];國際檢驗(yàn)醫(yī)學(xué)雜志;2012年21期

相關(guān)會(huì)議論文 前10條

1 孔祥瑞;丁霆;陳家倫;;血清鐵的正常值、晝夜變化及其營養(yǎng)和臨床意義[A];中國營養(yǎng)學(xué)會(huì)第四屆全國學(xué)術(shù)會(huì)議論文摘要匯編[C];1984年

2 于康;張思源;陳亭苑;杜壽玢;;嚴(yán)重感染病人血清鐵,鋅,銅和硒改變的初步觀察[A];中國營養(yǎng)學(xué)會(huì)第七屆全國營養(yǎng)學(xué)術(shù)會(huì)議論文摘要匯編[C];1996年

3 孔祥瑞;;血清鐵／銅比值及其臨床營養(yǎng)學(xué)意義[A];中國營養(yǎng)學(xué)會(huì)第四屆全國學(xué)術(shù)會(huì)議論文摘要匯編[C];1984年

4 李紅霞;;43例妊娠婦女血清貧血檢測(cè)指標(biāo)的分析[A];第五次全國中青年檢驗(yàn)醫(yī)學(xué)學(xué)術(shù)會(huì)議論文匯編[C];2006年

5 黃杰;;慢性乙型肝炎患者血清鐵檢測(cè)[A];中華醫(yī)學(xué)會(huì)第七次全國檢驗(yàn)醫(yī)學(xué)學(xué)術(shù)會(huì)議資料匯編[C];2008年

6 盧宏柱;袁岳沙;張萬明;劉丹;匡紅艷;;腎病綜合征患兒血清鐵指標(biāo)的變化[A];中華醫(yī)學(xué)會(huì)第十四次全國兒科學(xué)術(shù)會(huì)議論文匯編[C];2006年

7 張征;李寧;張宏群;高希寶;;濟(jì)南市健康人血清鐵、鈣含量調(diào)查及其影響因素的研究[A];第三屆泰山微量元素高級(jí)論壇匯編[C];2009年

8 曹軍皓;容東寧;劉愛華;陳敏;;SE-9000血液分析儀紅細(xì)胞鐵缺乏信息與血清鐵的對(duì)比[A];第十屆全軍檢驗(yàn)醫(yī)學(xué)學(xué)術(shù)會(huì)議論文匯編[C];2005年

9 鄒建洲;劉中華;沈波;林靜;湯穎;陳利明;滕杰;方藝;丁小強(qiáng);;維持性血液透析患者血清鐵指標(biāo)的流行病調(diào)查情況——單中心結(jié)果[A];2007年浙滬兩地腎臟病學(xué)術(shù)年會(huì)資料匯編[C];2007年

10 李婷;王彥;楊麗清;亓文璇;段丹波;;超敏C反應(yīng)蛋白及血清鐵與2型糖尿病患者頸動(dòng)脈硬化的關(guān)系[A];中華醫(yī)學(xué)會(huì)第十二次全國內(nèi)分泌學(xué)學(xué)術(shù)會(huì)議論文匯編[C];2013年

相關(guān)重要報(bào)紙文章 前3條

1 記者 胥金章;治療非典慎補(bǔ)鐵[N];新華每日電訊;2003年

2 胥金章;非典病人慎用補(bǔ)鐵劑[N];醫(yī)藥經(jīng)濟(jì)報(bào);2003年

3 盧風(fēng)松;補(bǔ)鐵過度易患冠心病[N];醫(yī)藥養(yǎng)生保健報(bào);2006年

相關(guān)碩士學(xué)位論文 前3條

1 張征;濟(jì)南市健康成年人血清鐵、鈣正常參考值調(diào)查及其環(huán)境、社會(huì)行為因素的影響研究[D];山東大學(xué);2009年

2 周健;心理應(yīng)激對(duì)大鼠血清鐵濃度的影響及機(jī)制探討[D];第二軍醫(yī)大學(xué);2007年

3 牛誠誠;兒童血清六種元素水平分析及各年齡段特點(diǎn)[D];吉林大學(xué);2015年

本文編號(hào)：1819238