本文選題：腹瀉 + 腸致病性大腸桿菌�。� 參考：《中華疾病控制雜志》2016年04期

【摘要】：目的了解廣州地區(qū)致瀉性大腸埃希菌感染情況、流行病學(xué)特征及耐藥情況。方法 2014年7月~2015年7月分別收集廣州地區(qū)某綜合醫(yī)院腹瀉患兒及健康兒童糞便標(biāo)本143份、83份,進(jìn)行細(xì)菌分離培養(yǎng),采用聚合酶鏈反應(yīng)檢測(cè)腸致病性大腸埃希菌、聚集性大腸埃希菌、產(chǎn)毒性大腸埃希菌和腸侵襲性大腸埃希菌,Kirby Bauer法(K-B紙片擴(kuò)散法)進(jìn)行藥敏試驗(yàn)。結(jié)果四種致瀉性大腸埃希菌在腹瀉患兒與健康兒童中的檢出率分別為1.4%、3.6%;2.8%、2.4%;1.4%、1.2%;0.7%、1.2%;腹瀉患兒3~7歲年齡段檢出率最高,占26.7%;然而,健康兒童中5~7歲年齡段檢出率最高,占8.4%。藥敏試驗(yàn)結(jié)果顯示,大腸埃希菌對(duì)四環(huán)素、氨芐西林耐藥率為52.6%~63.2%;頭孢類(lèi)耐藥率為5.3%~21.1%;多重耐藥率50.5%。結(jié)論致瀉性大腸埃希菌在腹瀉患兒及健康兒童均有檢出,并存在多重感染,提示致瀉性大腸埃希菌是機(jī)會(huì)感染菌;除此之外,耐藥及多重耐藥高,應(yīng)加強(qiáng)致瀉性大腸埃希菌監(jiān)測(cè)及管理抗生素使用。
[Abstract]:Objective to investigate the prevalence, epidemiological characteristics and drug resistance of diarrhea Escherichia coli in Guangzhou.Methods from July 2014 to July 2015, 143 fecal specimens of diarrhea children and healthy children were collected from a general hospital in Guangzhou area. The bacteria were isolated and cultured. Escherichia coli was detected by polymerase chain reaction (PCR).The drug sensitivity test was carried out by Kirby Bauer method and K-B disk diffusion method for agglomeration Escherichia coli, toxic Escherichia coli and enteric invasive Escherichia coli.Results the detection rates of four kinds of diarrhea Escherichia coli in diarrhea children and healthy children were 1.4 and 1.4, respectively. The detection rate of four kinds of diarrhea was 1.4 and 1.20.The detection rate of diarrhea was the highest in the age group of 3 to 7 years old, and the highest rate was in the age of 57 years old, accounting for 8.4% of the total number of healthy children.The results of drug sensitivity test showed that the resistance rate of Escherichia coli to tetracycline and ampicillin was 52.63.2cm, the resistance rate of cephalosporins was 5.3cm and the multidrug resistance rate was 50.5.Conclusion diarrhea Escherichia coli was detected in both children with diarrhea and healthy children, and had multiple infections, suggesting that diarrhea Escherichia coli is opportunistic infection, in addition, drug resistance and multidrug resistance are high.The surveillance and management of antibiotic use should be strengthened.
【作者單位】： 南方醫(yī)科大學(xué)公共衛(wèi)生與熱帶醫(yī)學(xué)學(xué)院流行病學(xué)教研室;
【分類(lèi)號(hào)】：R725.1;R446.5

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