發(fā)布時(shí)間：2018-03-20 23:48

  本文選題：細(xì)菌性肺炎　切入點(diǎn)：病原菌　出處：《中華醫(yī)院感染學(xué)雜志》2016年08期 　論文類型：期刊論文

【摘要】：目的分析細(xì)菌性肺炎患兒病原菌分布,探討聯(lián)合檢測(cè)多效生長(zhǎng)因子(PTN)與C-反應(yīng)蛋白(CRP)的臨床診斷價(jià)值,為臨床診斷及治療提供參考。方法選取醫(yī)院2013年6月-2015年6月診治的120例細(xì)菌性肺炎患兒進(jìn)行分析,其中輕度感染和重度感染患兒各60例,同期選取260名健康體檢兒童為對(duì)照組;采集細(xì)菌性肺炎患兒痰液分離細(xì)菌,采用法國生物梅里埃公司的API條和BD公司的PHOENIX-100TM全自動(dòng)微生物鑒定系統(tǒng)對(duì)進(jìn)行細(xì)菌鑒定,分析感染病原菌分布,對(duì)比3組兒童CRP、PTN、血清淀粉樣蛋白A(SAA)、腫瘤壞死因子α(TNFα)、白細(xì)胞介素(IL)等臨床指標(biāo),數(shù)據(jù)采用SPSS 19.0軟件進(jìn)行統(tǒng)計(jì)分析。結(jié)果 120例患兒中共分離出120株病原菌,以革蘭陰性菌為主,共70株占58.3%;感染患兒血清中CRP、PTN、SAA及TNFα、IL-1、IL-2和IL-6水平明顯升高,與對(duì)照組相比差異有統(tǒng)計(jì)學(xué)意義(P0.05),且重度感染患兒比輕度感染患兒升高更顯著(P0.05)。結(jié)論細(xì)菌性肺炎患兒易受到多種病原菌感染,感染后患兒血清炎癥因子水平明顯升高。
[Abstract]:Objective to analyze the distribution of pathogenic bacteria in children with bacterial pneumonia and to explore the clinical diagnostic value of combined detection of multi-effect growth factor (PTNN) and C-reactive protein (C- reactive protein). Methods from June 2013 to June 2015, 120 cases of bacterial pneumonia were analyzed, including 60 cases of mild infection and 60 cases of severe infection. In the same period, 260 healthy children were selected as the control group, the sputum of the children with bacterial pneumonia were collected to isolate bacteria, and the bacteria were identified by the API strip of French Bio-Meridier Company and the PHOENIX-100TM automatic Microbiological Identification system of BD Company. The distribution of pathogenic bacteria in infected children was analyzed, and the clinical indexes, such as CRPN, serum amyloid Astragalus, tumor necrosis factor 偽 -TNF- 偽, interleukin (IL), were compared among the three groups. The data were statistically analyzed by SPSS 19.0 software. Results 120 strains of pathogenic bacteria were isolated from 120 children. Gram-negative bacilli accounted for 70 strains (58.3%), and serum levels of CRPP-TNSAA and TNF 偽 IL-1IL-2 and IL-6 were significantly increased in infected children. Compared with the control group, the difference was statistically significant (P 0.05), and the level of serum inflammatory factors in the children with severe infection was significantly higher than that of the children with mild infection. Conclusion the children with bacterial pneumonia are susceptible to many kinds of pathogenic bacteria infection, and the serum inflammatory factor level of the children with severe infection is significantly higher than that of the children with mild infection.
【作者單位】： 南雄市人民醫(yī)院檢驗(yàn)科;
【基金】：廣東省科技廳基金資助項(xiàng)目[J20141103(025)]
【分類號(hào)】：R725.6;R446

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